Pinostilbene | CAS:42438-89-1 | Manufacturer ChemFaces

Pinostilbene

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Description:

Pinostilbene has protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells, it can reduce release of lactate dehydrogenase and activity of caspase-3 triggered by 6-hydroxydopamine (6-OHDA) in a dose-dependent manner. Pinostilbene can significantly inhibit the growth of human colon cancer cells, i.e., HCT116 and HT29, 20 and 40 uM of pinostilbene causes cell cycle arrest at S phase and induces apoptosis in colon cancer cells.

Targets:

Caspase | JNK

In vitro:

J Nutr Biochem. 2010 Jun;21(6):482-9.

Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.[Pubmed: 19443200]

Release of lactate dehydrogenase and activity of caspase-3 triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, Pinostilbene (3,4'-dihydroxy-5-methoxystilbene), in a dose-dependent manner. In addition, Pinostilbene exerted a potent neuroprotective effect with a wider effective concentration range than resveratrol.
METHODS AND RESULTS:
By using high-performance liquid chromatography, we found that uptake of Pinostilbene into SH-SY5Y cells was significantly higher than that of resveratrol. Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of Pinostilbene. Moreover, Western blot analysis demonstrated that Pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Besides, mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of Pinostilbene.
CONCLUSIONS:
Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.

Pinostilbene Description

Source:	The seeds of Vitis riparia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Mol Nutr Food Res. 2016 Sep;60(9):1924-32.

Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells.[Pubmed: 26990242]

Pterostilbene (PTE) is a resveratrol derivative mainly found in blueberries, and it has been shown to inhibit colon carcinogenesis in multiple animal models. To shed light on the mechanism of PTE in inhibiting colon carcinogenesis, we investigated the PTE metabolites in the mouse colon and in the human colon cancer cells. METHODS AND RESULTS: CD-1 mice were fed PTE-containing diet for 3 weeks, and colonic content and colonic mucosa were collected and subjected to LC-MS analysis. Pinostilbene (PIN) was identified as a major metabolite of PTE in the mouse colon. Importantly, the level of PIN was found to be approximately equivalent to that of PTE in the colonic mucosa. PIN significantly inhibited the growth of human colon cancer cells, i.e., HCT116 and HT29. These inhibitory effects were similar to those produced by PTE. Moreover, under physiologically relevant conditions, 20 and 40 μM of PIN caused cell cycle arrest at S phase and induced apoptosis in colon cancer cells. These effects were associated with profound modulation of signaling proteins related with cell proliferation and programmed cell death. CONCLUSION: Our results demonstrated that PIN is a major metabolite of PTE in the colon of mice fed with PTE, and PIN may play important roles in the anti-colon cancer effects elicited by orally administered PTE.

Product Name	Pinostilbene
Price:
CAS No.:	42438-89-1
Catalog No.:	CFN98662
Molecular Formula:	C₁₅H₁₄O₃
Molecular Weight:	242.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The seeds of Vitis riparia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Neuroprotection Compound Library Phenols Compound Library JNK Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1271 mL	20.6356 mL	41.2712 mL	82.5423 mL	103.1779 mL
5 mM	0.8254 mL	4.1271 mL	8.2542 mL	16.5085 mL	20.6356 mL
10 mM	0.4127 mL	2.0636 mL	4.1271 mL	8.2542 mL	10.3178 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	1.6508 mL	2.0636 mL
100 mM	0.0413 mL	0.2064 mL	0.4127 mL	0.8254 mL	1.0318 mL

CFN90911	Desoxyrhaponticin	30197-14-9	404.4	C₂₁H₂₄O₈
CFN91099	Rhaponticin 6''-O-gallate	94356-23-7	572.51	C₂₈H₂₈O₁₃
CFN91100	Rhaponticin 2''-O-gallate	94356-24-8	572.51	C₂₈H₂₈O₁₃
CFN99995	2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside	82373-94-2	406.39	C₂₀H₂₂O₉
CFN98662	Pinostilbene	42438-89-1	242.3	C₁₅H₁₄O₃
CFN95285	1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane	1338076-61-1	566.6	C₂₈H₃₈O₁₂
CFN98995	Pinostilbenoside	58762-96-2	404.4	C₂₁H₂₄O₈
CFN92587	5-Methoxy-3-stilbenol	5150-38-9	226.3	C₁₅H₁₄O₂
CFN92783	Thunalbene	220862-05-5	242.3	C₁₅H₁₄O₃
CFN91176	3'-O-Methylbatatasin III	101330-69-2	258.3	C₁₆H₁₈O₃