Plantagoside | CAS:78708-33-5 | Manufacturer ChemFaces

Plantagoside

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Description:

Plantagoside is a potent inhibitor of the Maillard reaction, it also can inhibit the formation of advanced glycation end products in proteins in physiological conditions and inhibit protein cross-linking glycation. It is also a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50 at 5 microM). Plantagoside suppresses antibody response to sheep red blood cells and concanavalin A induced lymphocyte proliferation which was measured by [3H]thymidine incorporation. Plantagoside has potential therapeutic applications in the prevention of diabetic complications.

Targets:

alpha-mannosidase

In vitro:

Biomed Res Int. 2014;2014:208539.

Potent protein glycation inhibition of plantagoside in Plantago major seeds.[Pubmed: 24895551 ]

METHODS AND RESULTS:
Plantagoside (5,7,4',5'-tetrahydroxyflavanone-3'-O-glucoside) and its aglycone (5,7,3',4',5'-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation.
CONCLUSIONS:
These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications.

Plantagoside Description

Source:	The herbs of Plantago asiatica
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biochem Biophys Res Commun. 1989 Dec 29;165(3):1292-8.

Plantagoside, a novel alpha-mannosidase inhibitor isolated from the seeds of Plantago asiatica, suppresses immune response.[Pubmed: 2610694]

A hot-water extract from the seed of Plantago asiatica showed a potent inhibitory activity against jack bean alpha-mannosidase, and a flavanone glucoside, Plantagoside, was isolated as the inhibitor.
METHODS AND RESULTS:
Plantagoside was a specific inhibitor for jack bean alpha-mannosidase (IC50 at 5 microM) and appeared to be a non-competitive inhibitor of the enzyme. Whereas, negligible or weak inhibitory activities were observed for beta-mannosidase, beta-glucosidase, and sialidase tested. Plantagoside also inhibited alpha-mannosidase activities in mouse liver lysosomal and microsomal fractions, and the enzyme inhibitory activity in microsomal fraction was enhanced in the presence of glucosidase inhibitor, castanospermine. Plantagoside suppressed antibody response to sheep red blood cells and concanavalin A induced lymphocyte proliferation which was measured by [3H]thymidine incorporation.

Product Name	Plantagoside
Price:
CAS No.:	78708-33-5
Catalog No.:	CFN91894
Molecular Formula:	C₂₁H₂₂O₁₂
Molecular Weight:	466.39 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Plantago asiatica
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1441 mL	10.7206 mL	21.4413 mL	42.8826 mL	53.6032 mL
5 mM	0.4288 mL	2.1441 mL	4.2883 mL	8.5765 mL	10.7206 mL
10 mM	0.2144 mL	1.0721 mL	2.1441 mL	4.2883 mL	5.3603 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	0.8577 mL	1.0721 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	0.4288 mL	0.536 mL

CFN97285	2',5,6',7-Tetrahydroxyflavanone	80604-16-6	288.3	C₁₅H₁₂O₆
CFN97286	2',5,6',7-Tetraacetoxyflavanone	80604-17-7	456.4	C₂₃H₂₀O₁₀
CFN98949	Steppogenin	56486-94-3	288.3	C₁₅H₁₂O₆
CFN99673	3',5,5',7-Tetrahydroxyflavanone	160436-10-2	288.3	C₁₅H₁₂O₆
CFN99278	Blumeatin	118024-26-3	302.3	C₁₆H₁₄O₆
CFN98672	Robtin	4382-34-7	288.3	C₁₅H₁₂O₆
CFN91894	Plantagoside	78708-33-5	466.39	C₂₁H₂₂O₁₂
CFN95414	3',4',5',5,7-Pentamethoxyflavanone	479672-30-5	374.4	C₂₀H₂₂O₇
CFN98393	5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavanone	310888-07-4	362.3	C₁₈H₁₈O₈
CFN95376	5,6,7,3',4',5'-Hexamethoxyflavanone	74064-17-8	404.4	C₂₁H₂₄O₈