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    Natural Products
    CAS No. 10376-48-4 Price $90 / 20mg
    Catalog No.CFN99784Purity>=98%
    Molecular Weight426.72Type of CompoundTriterpenoids
    FormulaC30H50OPhysical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $38.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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    Related Libraries
  • Anti-inflammatory Compound Library
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  • Biological Activity
    Description: Shionone has anti-inflammatory effect, the mechanism is related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS. It can inhibit the activity of ubiquitin-specific protease 2 (USP2) and provide a lead compound for future development of new USP2 inhibitors.
    Targets: ERK | IkB | NOS | IKK
    In vitro:
    China Journal of Traditional Chinese Medicine & Pharmacy, 2016(4):1430-3.
    Study on anti-inflammatory mechanism of shionone based on NF-κB pathway in vitro.[Reference: WebLink]
    To explore anti-inflammatory effect and mechanism of Shionone in vitro.
    Lipopolysaccharide(LPS)-activated macrophage cells(RAW264.7) were employed as an inflammatory model, which was intervened by the Shionone. After the experiment, Western blot was used to detect the protein expression of p-ERK1/2, IκBαand iNOS on the macrophage cells. Compared with the LPS group, the Shionone significantly decreased the protein expression of p-ERK1/2 and i NOS(P0.05) and significantly increased the protein expression of IκBα(P0.05).
    The antiinflammatory mechanism of Shionone was related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS.
    In vivo:
    J Ethnopharmacol. 2015 Apr 22;164:328-33.
    Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricu[Pubmed: 25701752]
    The root of Aster tataricus L. f., recorded in all versions of Chinese Pharmacopoeia, is a traditional Chinese medicine with the function of dispelling phlegm and relieving cough for more than 2000 years. This study was designed to evaluate the expectorant, antitussive, and anti-inflammatory activities of the root of A. tataricus and to explore the chemical substances responsible for these activities.
    The 70% ethanol extract of the root of A. tataricus (RA-70) was divided into three fractions, Fr-0, Fr-50 and Fr-95. They were all orally administrated to the mice to investigate their potential expectorant activities by a tracheal phenol red secretion method. The most effective fraction, together with Shionone, was evaluated the expectorant, antitussive and anti-inflammatory activities by the mouse models of phenol red secretion, ammonia-induced cough, and xylene-induced ear swelling. Furthermore, the chemical components of the effective fraction were analyzed and identified by an HPLC-Q-TOF/MS method. Treatment with RA-70, Fr-0 and Fr-50 increased the amount of phenol red secretion by 65.3%, 56.5%, and 76.9%, respectively. Fr-50 was chosen for the further investigation and the results showed that Fr-50 at 40, 80 mg/kg significantly enhanced the phenol red secretion of tracheas, increased the latent period and decreased the frequency of cough and inhibited the ear edema in mice. Shionone at 80 mg/kg showed the trend of enhancing sputum secreting, but had no effect on ammonia-induced cough and xylene-induced ear edema. HPLC-Q-TOF/MS analysis indicated that Fr-50 was mainly composed of 12 caffeoylquinic acids (40.8%, in relative peak area), 7 astersaponins (12.0%) and 13 astins/asterinins (pentapeptides, 26.5%).
    The root of A. tataricus has significant expectorant, antitussive and anti-inflammatory effects. Caffeoylquinic acids, astersaponins, and aster peptides, rather than Shionone, may be the main constituents responsible for the expectorant and antitussive activities of A. tataricus and act in a synergistic way.
    Shionone Description
    Source: The flowers of Chrysanthemum morifolium
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to:

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3435 mL 11.7173 mL 23.4346 mL 46.8691 mL 58.5864 mL
    5 mM 0.4687 mL 2.3435 mL 4.6869 mL 9.3738 mL 11.7173 mL
    10 mM 0.2343 mL 1.1717 mL 2.3435 mL 4.6869 mL 5.8586 mL
    50 mM 0.0469 mL 0.2343 mL 0.4687 mL 0.9374 mL 1.1717 mL
    100 mM 0.0234 mL 0.1172 mL 0.2343 mL 0.4687 mL 0.5859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kinase Assay:
    Journal of Shanghai Jiaotong University, 2014, 34(11):1563-7.
    Inhibitory effect of shionone on activity of ubiquitin-specific protease 2[Reference: WebLink]
    To identify new ubiquitin-specific protease 2 (USP2) inhibitors from natural compounds.
    The Ub-CHOP-Reporter Kit was used to screen USP2 inhibitors. NB4 cells were treated by Shionone (SH) of 100 μmol/L for different periods of time. Variations of the expression of USP2 targeted protein Cyclin D1 were detected by the Western blotting. The distribution of cell cycle was detected by the flow cytometry and molecular docking was used to analyze the binding of SH and USP2. The results of screening in vitro showed that SH inhibited the activity of USP2 with the 50% inhibition concentration (IC50) of 69 μmol/L. The results of Western blotting indicated that SH led to the decrease of Cyclin D1 expression. The results of flow cytometry showed that typical apoptotic peak (Sub-G1 peak) appeared and cells in S and G2/M phases decreased after being treated by SH for 48 h. The results of molecular docking indicated that the oxygen atom and skeleton core of SH and K503, W439, R363, and D440 of USP2 were essential for the binding of SH and USP2.
    SH can inhibit the activity of USP2 and provide a lead compound for future development of new USP2 inhibitors.
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):738-40.
    [Determination of shionone in Radix Asteris by HPLC].[Pubmed: 15015355]
    To determine the content of Shionone in Radix Aster from several different locations and markets.
    The HPLC analysis was used to determine Shionone directly, using Polaris C18 column and acetonitrile as the mobile phase with a flow rate of 1.0 mL.min-1, and the UV detection wavelength was 200 nm.
    The content of Shionone was from 0.06% to 0.18%, depending on different locations and markets.