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3. Inhibitors
Platyconic acid A
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $681.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Int J Mol Sci.2017, 18(12)Kor. J. Herbol.2022, 37(5): 89-96.Int J Mol Med.2019, 43(6):2516-2522Molecules.2021, 26(4):1084.Plants (Basel).2023, 12(1):163.Front Immunol.2018, 9:2655Sci Rep.2021, 11(1):10931.Research Square2020, doi: 10.21203.
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Platyconic acid A
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Mol Microbiol.2019, 112(1):317-332Evid-Based Compl Alt2020, 7202519:13J Biochem Mol Toxicol.2017, 31(9)Metabolites.2020, 10(11):440.Biol Pharm Bull.2018, 41(11):1685-1693Food Research2021, 5(1):65-71Carbohydrate Polymer Technologies & App.2021, 2:100049.Acta Edulis Fungi2020, 27(02):63-76.Aging (Albany NY).2021, 13(19):22867-22882.Fitoterapia.2015, 100:179-86
Related Screening Libraries
| Description: |
Platyconic acid A suppresses the development of respiratory inflammation, hyperresponsiveness, and remodeling by reducing allergic responses, and it may be a potential herbal drug for allergen-induced respiratory disease prevention. Platyconic acid A suppresses PMA-induced MUC5AC mRNA expression by inhibiting NF-κB activation via Akt in A549 cells. |
| Targets: |
NF-kB | Akt | HCV |
| In vitro: |
| Evid Based Complement Alternat Med. 2013;2013:560417. | | Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.[Pubmed: 24489585 ] | Hepatitis C virus (HCV) infection is a major cause of liver disease, including cirrhosis and hepatocellular carcinoma. Due to significant adverse effects and emergence of resistant strains of currently developed anti-HCV agents, plant extracts have been considered to be potential sources of new bioactive compounds against HCV.
The aim of this study was to evaluate the functional effects of triterpenoid saponins contained in the root extract of Platycodon grandiflorum (PG) on viral enzyme activities and replication in both HCV replicon cells and cell culture grown HCV- (HCVcc-) infected cells.
METHODS AND RESULTS:
Inhibitory activities of triterpenoid saponins from PG were verified by NS5B RNA-dependent RNA polymerase assay and were further confirmed in the context of HCV replication. Six triterpenoid saponins (platycodin D, platycodin D2, platycodin D3, deapioplatycodin D, deapioplatycodin D2, and Platyconic acid A), PG saponin mixture (PGSM), were identified as active components exerting anti-HCV activity. Importantly, PGSM exerted synergistic anti-HCV activity in combination with either interferon- α or NS5A inhibitors. We demonstrated that combinatorial treatment of PGSM and IFN- α efficiently suppressed colony formation with significant reduction in drug resistant variant of HCV.
CONCLUSIONS:
These data suggest that triterpenoid saponin may represent a novel anti-HCV therapeutic agent. |
|
| In vivo: |
| J Agric Food Chem. 2015 Feb 11;63(5):1468-76. | | Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells.[Pubmed: 25590691] |
METHODS AND RESULTS:
We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number, IgE, Th1/Th2 cytokines, and MCP-1 chemokine secretion in bronchoalveolar lavage fluid. Also, ovalbumin-increased MUC5AC, MMP-2/9, and TIMP-1/-2 mRNA expression, NF-κB activation, leukocytes recruitment, and mucus secretion were inhibited by CKS treatment. Moreover, the active component of CKS, Platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 ± 0.2 to 1.1 ± 0.1) by inhibiting NF-κB activation (from 2.3 ± 0.2 to 1.2 ± 0.1) via Akt (from 3.7 ± 0.3 to 2.1 ± 0.2) (p < 0.01) in A549 cells.
CONCLUSIONS:
Therefore, we demonstrate that CKS or PA suppressed the development of respiratory inflammation, hyperresponsiveness, and remodeling by reducing allergic responses, and they may be potential herbal drugs for allergen-induced respiratory disease prevention. |
|
Platyconic acid A Description
| Source: |
The roots of Platycodon grandiflorum |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
0.8069 mL |
4.0345 mL |
8.0691 mL |
16.1381 mL |
20.1727 mL |
| 5 mM |
0.1614 mL |
0.8069 mL |
1.6138 mL |
3.2276 mL |
4.0345 mL |
| 10 mM |
0.0807 mL |
0.4035 mL |
0.8069 mL |
1.6138 mL |
2.0173 mL |
| 50 mM |
0.0161 mL |
0.0807 mL |
0.1614 mL |
0.3228 mL |
0.4035 mL |
| 100 mM |
0.0081 mL |
0.0403 mL |
0.0807 mL |
0.1614 mL |
0.2017 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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