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Platycoside E
Platycoside E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Platycoside E
Price:
CAS No.: 237068-41-6
Catalog No.: CFN90786
Molecular Formula: C69H112O38
Molecular Weight: 1549.6 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The roots of Platycodon grandiflorum.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Deutsches Krebsforschungszentrum (Germany)
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  • Anna University (India)
  • Universidade Federal de Santa C... (Brazil)
  • Universidad Miguel Hernández (Spain)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Platycoside E can significantly promote the production of the sera ovalbumin (OVA)-specific IgG2a and IgG2b antibody in the OVA-immunized mice.
Targets: IFN-γ | IL Receptor
In vivo:
Vaccine, 2008, 26(27-28):3452-60.
Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum.[Pubmed: 18501482 ]
Platycodin D (PD), platycodin D3 (PD3), and Platycoside E (PE) were the platycodigenin-type saponins isolated from the root of Platycodon grandiflorum.
METHODS AND RESULTS:
To assess the potential contribution of the glycidic chains to the biological activities and elucidate the structure-activity relationships of the platycodigenin-type saponins, these three saponins were evaluated for their haemolytic activities and adjuvant potentials on the cellular and humoral immune responses of mice against ovalbumin (OVA). Among three saponins, the ranking of the haemolytic activity was PD>PD3>PE (P<0.001). PD and PD3 could significantly enhance mitogen- and OVA-induced splenocyte proliferation in the OVA-immunized mice (P<0.001). The order of increasing OVA-stimulated splenocyte proliferation was PD>PD3>PE (P<0.05, P<0.01, or P<0.001). The sera OVA-specific IgG, IgG1, IgG2a and IgG2b antibody levels in the OVA-immunized mice were significantly enhanced by PD and PD3. However, PE only significantly promoted the production of the sera OVA-specific IgG2a and IgG2b antibody in the OVA-immunized mice. Adjuvant potentials of PD on antibody responses were higher than those of PD3 and PE (P<0.05, P<0.01, or P<0.001). Meanwhile, PD also significantly enhanced the mRNA expression of cytokines IL-2, IFN-gamma, IL-4, and IL-10 and transcription factors T-bet and GATA-3 in mice splenocyte induced by Con A (P<0.05, P<0.01, or P<0.001).
CONCLUSIONS:
These results suggested that the number of sugar residues in the glycidic chains attached to C-3 of aglycone could affect the haemolytic and adjuvant activities of platycodigenin-type saponins, and that PD had immunological adjuvant activity, and simultaneously elicited a Th1 and Th2 immune response by regulating gene expression of Th1/Th2 cytokines and transcription factors.
Platycoside E Description
Source: The roots of Platycodon grandiflorum.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.6453 mL 3.2266 mL 6.4533 mL 12.9066 mL 16.1332 mL
5 mM 0.1291 mL 0.6453 mL 1.2907 mL 2.5813 mL 3.2266 mL
10 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.2907 mL 1.6133 mL
50 mM 0.0129 mL 0.0645 mL 0.1291 mL 0.2581 mL 0.3227 mL
100 mM 0.0065 mL 0.0323 mL 0.0645 mL 0.1291 mL 0.1613 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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