Sappanol | CAS:111254-19-4 | Manufacturer ChemFaces

Sappanol

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Description:

Sappanol inhibits lipid peroxidation in a concentration-dependent manner, can significantly attenuated H2O2-induced retinal death, can be potential antioxidant treatment for retinal diseases.

Targets:

ROS

In vitro:

BMB Rep. 2015 May;48(5):289-94.

One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death.[Pubmed: 25248564 ]

Caesalpinia sappan is a well-distributed plant that is cultivated in Southeast Asia, Africa, and the Americas. C. sappan has been used in Asian folk medicine and its extract has been shown to have pharmacological effects.
METHODS AND RESULTS:
Two homoisoflavonoids, Sappanol and brazilin, were isolated from C. sappan by using centrifugal partition chromatography (CPC), and tested for protective effects against retinal cell death. The isolated homoisoflavonoids produced approximately 20-fold inhibition of N-retinylidene-N-retinyl-ethanolamine (A2E) photooxidation in a dose-dependent manner. Of the 2 compounds, brazilin showed better inhibition (197.93 ± 1.59 μM of IC50). Cell viability tests and PI/Hoechst 33342 double staining method indicated that compared to the negative control, Sappanol significantly attenuated H2O2-induced retinal death.
CONCLUSIONS:
The compounds significantly blunted the up-regulation of intracellular reactive oxygen species (ROS), and Sappanol inhibited lipid peroxidation in a concentration-dependent manner. Thus, both compounds represent potential antioxidant treatments for retinal diseases.

Sappanol Description

Source:	The heartwoods of Caesalpinia sappan Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Sappanol
Price:
CAS No.:	111254-19-4
Catalog No.:	CFN92832
Molecular Formula:	C₁₆H₁₆O₆
Molecular Weight:	304.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The heartwoods of Caesalpinia sappan Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Anti-retinopathy Compound Library Flavonoids Compound Library ROS Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2862 mL	16.4312 mL	32.8623 mL	65.7246 mL	82.1558 mL
5 mM	0.6572 mL	3.2862 mL	6.5725 mL	13.1449 mL	16.4312 mL
10 mM	0.3286 mL	1.6431 mL	3.2862 mL	6.5725 mL	8.2156 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.3145 mL	1.6431 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6572 mL	0.8216 mL

CFN92770	3'-Deoxy-4-O-methylsappanol	112408-68-1	302.3	C₁₇H₁₈O₅
CFN92964	Sappanone B	104778-15-6	302.28	C₁₆H₁₄O₆
CFN98844	2-Hydroxy-7-O-methylscillascillin	52096-50-1	342.3	C₁₈H₁₄O₇
CFN98869	Scillascillin	52706-07-7	312.3	C₁₇H₁₂O₆
CFN99209	7,3',4'-Trihydroxy-3-benzyl-2H-chromene	1111897-60-9	270.3	C₁₆H₁₄O₄
CFN92962	Episappanol	111254-18-3	304.29	C₁₆H₁₆O₆
CFN92769	4-O-Methylepisappanol	112529-37-0	318.3	C₁₇H₁₈O₆
CFN92771	3'-Deoxy-4-O-methylepisappanol	1052714-12-1	302.3	C₁₇H₁₈O₅
CFN92832	Sappanol	111254-19-4	304.3	C₁₆H₁₆O₆
CFN99068	4-O-Methylsappanol	104778-16-7	318.3	C₁₇H₁₈O₆