Schisantherin B | CAS:58546-55-7 | Manufacturer ChemFaces

Schisantherin B

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Schisantherin B
Price:	$130 / 20mg
CAS No.:	58546-55-7
Catalog No.:	CFN99924
Molecular Formula:	C₂₈H₃₄O₉
Molecular Weight:	514.57 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	White powder
Source:	The seeds of Schisandra chinensis (Turcz.) Baill.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $28.1 / In-stock
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Description:

Schisantherin B may protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the glutamate transporter type 1 (GLT-1) restoration as well as the capacity of Glycogen synthase kinase3β(GSK3β), it also shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.

Targets:

P450 (e.g. CYP17) | GSK-3 | Beta Amyloid

In vivo:

Phytomedicine. 2014 Apr 15;21(5):766-72.

Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.[Pubmed: 24462213]

We recently reported that Wuzhi tablet (WZ), a preparation of the ethanol extract of Wuweizi (Schisandra sphenanthera), had significant effects on blood concentrations of Tacrolimus (FK506) in renal transplant recipients and rats. The active lignans in WZ are schisandrin A, schisandrin B, schisandrin C, schisandrol A, schisandrol B, schisantherin A, and Schisantherin B. Until now, whether the pharmacokinetics of these lignans in WZ would be affected by FK506 remained unknown.
METHODS AND RESULTS:
Therefore, this study aimed to investigate whether and how FK506 affected pharmacokinetics of lignans in WZ in rats and the potential roles of CYP3A and P-gp. After a single oral co-administration of FK506 and WZ, the blood concentration of lignans in WZ was decreased by FK506; furthermore, the AUC of schisantherin A, schisandrin A, schisandrol A and schisandrol B was only 64.5%, 47.2%, 55.1% and 57.4% of that of WZ alone group, respectively. Transport study in Caco-2 cells showed that these lignans were not substrates of P-gp, suggesting decreased blood concentration of lignans by FK506 was not via P-gp pathway. Metabolism study in the human recombinant CYP 3A showed that these lignans had higher affinity to CYP3A than that of FK506, and thus had a stronger CYP3A-mediated metabolism.
CONCLUSIONS:
It was concluded that the blood concentrations of these lignans were decreased and their CYP3A-mediated metabolisms were increased in the presence of FK506 since these lignans had higher affinity to CYP3A.

Schisantherin B Description

Source:	The seeds of Schisandra chinensis (Turcz.) Baill.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Physiol Behav. 2016 Dec 1;167:265-273.

Schisantherin B ameliorates Aβ1-42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease.[Pubmed: 27660034]

Accumulation of amyloid beta (Aβ) peptide and hyperphosphorylated tau protein has been proposed to play roles in neural destruction which induce Alzheimer's disease (AD) progresses, glutamate transporter type 1 (GLT-1) and Glycogen synthase kinase3β (GSK3β) may be the pathological links between Aβ and tau pathology. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years.
METHODS AND RESULTS:
This paper was designed to investigate the effects of STB on improving the cognitive function and neurodegeneration in the mouse model of Alzheimer's disease induced by Aβ1-42, and its possible mechanism were Glutamate transporter GLT-1, tau and GSK3β. It was found that successive intracerebroventricular (ICV) administration of STB (0.15mg/kg) for 5days significantly attenuated Aβ1-42-induced learning and memory impairment as measured by the Locomotor activity test, Y-maze test and Morris water maze test. Furthermore, STB at a dose of 0.15mg/kg restored the activities of GLT-1 and GSK3β while decreasing the levels of hyperphosphorylated tau protein in the hippocampus and cerebral cortex.
CONCLUSIONS:
The results suggested that STB might protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the GLT-1 restoration as well as the capacity of GSK3β.

Structure Identification:

J Nat Prod. 2006 Dec;69(12):1697-701.

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.[Pubmed: 17190445]

METHODS AND RESULTS:
Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans rubrisandrins A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, Schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques.
CONCLUSIONS:
Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.

Sci Sin. 1978 Jul-Aug;21(4):483-502.

Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds.[Pubmed: 233922]

METHODS AND RESULTS:
Deoxyschisandrin (VIII) and five new lignans, named schisantherin A, Schisantherin B, C, D, and E, were isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils. Their configurations and conformations were established by exhaustive spectral analysis as well as chemical degradations as shown in Ia, Ib; IIa, IIb; IIIa, IIIb; IVa, IVb, and Va, Vb respectively, and their absolute configurations at biphenyl, at C6, C7, and C8 were all assigned to be S form. The position of the methylenedioxyl group in the structures of gamma-schisandrin and Wuweizisu C (as described in the literature), isolated from Schisandra chinensis, must be corrected as shown in VI and VII respectively.
CONCLUSIONS:
In pharmacologica studies and preliminary clinical trials, schisantherin A,Schisantherin B, C, and D showed good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Schisantherin E and deoxyschisandrin were not effective.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library P450 (e.g. CYP17) Inhibitor Library GSK-3 Inhibitor Library Beta Amyloid Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9434 mL	9.7169 mL	19.4337 mL	38.8674 mL	48.5843 mL
5 mM	0.3887 mL	1.9434 mL	3.8867 mL	7.7735 mL	9.7169 mL
10 mM	0.1943 mL	0.9717 mL	1.9434 mL	3.8867 mL	4.8584 mL
50 mM	0.0389 mL	0.1943 mL	0.3887 mL	0.7773 mL	0.9717 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.3887 mL	0.4858 mL

CFN96618	Tigloylgomisin H	66069-55-4	500.59	C₂₈H₃₆O₈
CFN96939	Benzoylgomisin H	66056-23-3	522.59	C₃₀H₃₄O₈
CFN95223	Schisphenin E	1311376-52-9	432.5	C₂₄H₃₂O₇
CFN90878	Schisantherin E	64917-83-5	538.6	C₃₀H₃₄O₉
CFN96727	Angeloylgomisin Q	72561-28-5	530.61	C₂₉H₃₈O₉
CFN90710	Angeloylgomisin H	66056-22-2	500.58	C₂₈H₃₆O₈
CFN92350	Schisanwilsonin H	1181216-83-0	536.6	C₃₀H₃₂O₉
CFN92728	Kadsurin	51670-40-7	458.5	C₂₅H₃₀O₈
CFN90733	Epigomisin O	73036-31-4	416.46	C₂₃H₂₈O₇
CFN90751	Gomisin O	72960-22-6	416.46	C₂₃H₂₈O₇