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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $60.8 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Biochem Mol Toxicol....2020...Eur J Neurosci.2021, 53(11):3548-3560.J Pharmaceutical and Biomedical A...2022...Plant Methods.2017, 13:108Tropical Journal of Pharmaceutica...2021...J Agric Food Chem.2016, 64(35):6783-90Oncol Rep.2019, 41(4):2453-2463Sci Rep.2018, 8(1)
Evid Based Complement Alternat Me...2019...Molecules.2019, 24(10):E1926Chin J Appl. Physiol....2019...Dicle Tip Dergisi2020, 47(2),423-430.Phytother Res.2016, 30(12):2020-2026Asian J Beauty Cosmetol...2019...Braz J Med Biol Res....2021...Int J Mol Sci.2020, 21(6):2190.
Antimicrob Agents Chemother....2020...J of Applied Pharmaceutical Scien...2020...Cancers (Basel).2021, 13(17):4327.Acta Chromatographica2016, 29(3)Molecules.2021, 26(18):5665.Food Sci Biotechnol....2021...New Zealand J. Forestry Sci.2014, 44:17
Our products had been exported to the following research institutions and universities, And still growing.
University of Pretoria (South Africa)Universit?t Basel (Switzerland)National Cancer Institute (USA)Molecular Biology Institute of ... (Spain)
Max Rubner-Institut (MRI) (Germany)Univerzita Karlova v Praze (Czech Republic)University of Hertfordshire (United Kingdom)Siksha O Anusandhan University (India)
University of Hull (United Kingdom)Universidad Industrial de Santa... (Colombia)Leibniz Institute of Plant Bioc... (Germany)
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Agronomy2020, 10(3),388.Life Sci.2021, 270:119074.J Sep Sci.2020, 43(22):4148-4161.J of Pharmaceutical Analysis2020, doi: 10.1016Ulm University Medical Center2020, doi: 10.18725.Fitoterapia.2022, 157:105130.Braz J Med Biol Res.2021, 54(12):e11183.Nat Plants.2016, 3:16205Oncotarget.2017, 9(3):4161-4172Biochem Biophys Res Commun.2017, 482(4):1095-1101
Related Screening Libraries
||Schisantherin B may protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the glutamate transporter type 1 (GLT-1) restoration as well as the capacity of Glycogen synthase kinase3β(GSK3β), it also shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
||P450 (e.g. CYP17) | GSK-3 | Beta Amyloid|
|Phytomedicine. 2014 Apr 15;21(5):766-72. |
|Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.[Pubmed: 24462213]|
|We recently reported that Wuzhi tablet (WZ), a preparation of the ethanol extract of Wuweizi (Schisandra sphenanthera), had significant effects on blood concentrations of Tacrolimus (FK506) in renal transplant recipients and rats. The active lignans in WZ are schisandrin A, schisandrin B, schisandrin C, schisandrol A, schisandrol B, schisantherin A, and Schisantherin B. Until now, whether the pharmacokinetics of these lignans in WZ would be affected by FK506 remained unknown.
METHODS AND RESULTS:
Therefore, this study aimed to investigate whether and how FK506 affected pharmacokinetics of lignans in WZ in rats and the potential roles of CYP3A and P-gp. After a single oral co-administration of FK506 and WZ, the blood concentration of lignans in WZ was decreased by FK506; furthermore, the AUC of schisantherin A, schisandrin A, schisandrol A and schisandrol B was only 64.5%, 47.2%, 55.1% and 57.4% of that of WZ alone group, respectively. Transport study in Caco-2 cells showed that these lignans were not substrates of P-gp, suggesting decreased blood concentration of lignans by FK506 was not via P-gp pathway. Metabolism study in the human recombinant CYP 3A showed that these lignans had higher affinity to CYP3A than that of FK506, and thus had a stronger CYP3A-mediated metabolism.
It was concluded that the blood concentrations of these lignans were decreased and their CYP3A-mediated metabolisms were increased in the presence of FK506 since these lignans had higher affinity to CYP3A.
Schisantherin B Description
||The seeds of Schisandra chinensis (Turcz.) Baill.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Physiol Behav. 2016 Dec 1;167:265-273. |
|Schisantherin B ameliorates Aβ1-42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease.[Pubmed: 27660034]|
|Accumulation of amyloid beta (Aβ) peptide and hyperphosphorylated tau protein has been proposed to play roles in neural destruction which induce Alzheimer's disease (AD) progresses, glutamate transporter type 1 (GLT-1) and Glycogen synthase kinase3β (GSK3β) may be the pathological links between Aβ and tau pathology. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years.
METHODS AND RESULTS:
This paper was designed to investigate the effects of STB on improving the cognitive function and neurodegeneration in the mouse model of Alzheimer's disease induced by Aβ1-42, and its possible mechanism were Glutamate transporter GLT-1, tau and GSK3β. It was found that successive intracerebroventricular (ICV) administration of STB (0.15mg/kg) for 5days significantly attenuated Aβ1-42-induced learning and memory impairment as measured by the Locomotor activity test, Y-maze test and Morris water maze test. Furthermore, STB at a dose of 0.15mg/kg restored the activities of GLT-1 and GSK3β while decreasing the levels of hyperphosphorylated tau protein in the hippocampus and cerebral cortex.
The results suggested that STB might protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the GLT-1 restoration as well as the capacity of GSK3β.
|J Nat Prod. 2006 Dec;69(12):1697-701. |
|Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.[Pubmed: 17190445]|
METHODS AND RESULTS:
Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans rubrisandrins A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, Schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques.
Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.
|Sci Sin. 1978 Jul-Aug;21(4):483-502. |
|Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds.[Pubmed: 233922]|
METHODS AND RESULTS:
Deoxyschisandrin (VIII) and five new lignans, named schisantherin A, Schisantherin B, C, D, and E, were isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils. Their configurations and conformations were established by exhaustive spectral analysis as well as chemical degradations as shown in Ia, Ib; IIa, IIb; IIIa, IIIb; IVa, IVb, and Va, Vb respectively, and their absolute configurations at biphenyl, at C6, C7, and C8 were all assigned to be S form. The position of the methylenedioxyl group in the structures of gamma-schisandrin and Wuweizisu C (as described in the literature), isolated from Schisandra chinensis, must be corrected as shown in VI and VII respectively.
In pharmacologica studies and preliminary clinical trials, schisantherin A,Schisantherin B, C, and D showed good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Schisantherin E and deoxyschisandrin were not effective.