ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Jour. of Stored Pro & Postharvest...2016...Cell Physiol Biochem....2017...Front Pharmacol.2017, 8:205Food Chem.2018, 262:78-85Sci Adv.2018, 4(10)Korean Journal of Pharmacognosy...2018...Biochem Biophys Res Commun....2018...Sci Rep.2018, 8:15059
Nutr Metab (Lond).2019, 16:31BMC Complement Altern Med....2019...Molecules.2019, 24(22):E4022Pharmaceutical Chemistry Journal...2019...Plos One.2019, 15(2):e0220084Food Chem.2020, 313:126079Drug Chem Toxicol.2020, 1-12.Food Res Int.2020, 133:109130.
Molecules.2020, 25(23):5609. Molecules.2020, 25(9):2081.J Microbiol Biotechnol....2020...Plants (Basel).2020, 9(11):1535.Antioxidants (Basel).2020, 9(4):326. ACS Synth Biol.2020, 9(9):2282-2290.Naunyn Schmiedebergs Arch Pharmac...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Univerzita Karlova v Praze (Czech Republic)Martin Luther University of Hal... (Germany)Universita' Degli Studi Di Cagl... (Italy)China Medical University (Taiwan)
Siksha O Anusandhan University (India)Korea Intitute of Science and T... (Korea)Florida International University (USA)Technical University of Denmark (Denmark)
Universidade Católica Portuguesa (Portugal)Periyar University (India)Chiang Mai University (Thailand)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2019, 24(6):E1155Int. J. of Food Properties2017, S108-S118 The Journal of Agromedicine and Medical Sciences2018, 4(1)BMC Complement Altern Med.2018, 18(1):221Antioxidants (Basel).2020, 9(4):284.Bulletin of Health Research2016, 44(4):279-286Food Chem.2019, 278:683-691Chemistry of Plant Materials.2019, 129-136Auburn University2015, 1-58Korean Journal of Pharmacognosy2017, 48(4):320-328
Related Screening Libraries
|| Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
||NO | NOS | IFN-γ | Antifection|
|Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9. |
|Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]|
METHODS AND RESULTS:
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
|Planta Med. 2004 Jan;70(1):76-8. |
|In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]|
|In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
METHODS AND RESULTS:
Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
Sikokianin C Description
||The roots of Wikstroemia indica.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.