ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J of App. Res. on Med&Aromatic Pl...2020...Int J Mol Sci.2019, 20(16):E4015Curr Top Med Chem....2020...LWT2020, 126:109313Trop J Nat Prod Res.2019, 3(1):6-9J Food Compos Anal2017, 62:197-204Biosci Biotechnol Biochem....2020...Tropical Journal of Pharmaceutica...2021...
J Nat Med.2020, 74(3):550-560.Applied Biological Chemistry...2020...Int J Mol Sci.2019, 20(14):E3538J of Health Science and Alternati...2019...Molecules.2019, 24(17):E3127Food Chem.2021, 360:130063.J Liq Chromatogr R T...2018...Molecules.2020 ,25(16):3697.
J Appl Microbiol.2022, 132(2):949-963.Front Neurosci.2019, 13:1091J Agric Food Chem....2021...Oxid Med Cell Longev....2021...Front Plant Sci.2020, 10:1705Nat Prod Commun.2017, 12(5):771-778Food Analytical Methods...2017...
Our products had been exported to the following research institutions and universities, And still growing.
University of Toronto (Canada)University of Hertfordshire (United Kingdom)University of Beira Interior (Portugal)Instituto de Investigaciones Ag... (Chile)
The Australian National University (Australia)University of Fribourg (Switzerland)Institute of Chinese Materia Me... (China)Complutense University of Madrid (Spain)
University of British Columbia (Canada)Uniwersytet Jagielloński w Kra... (Poland)Florida A&M University (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Natural Product Communications2020, doi: 10.1177.Phytomedicine.2021, 93:153789. Evid Based Complement Alternat Med.2021, 8707280.Toxicol In Vitro.2018, 52:94-105Int J Mol Sci.2019, 20(9):E2244Nutrients.2021, 13(12):4364.Advances in Traditional Medicine 2021, 21:779-789.International. J. of Food Properties 2017, 20:S131-S140Pharmaceuticals (Basel).2020, 13(10):302.Anticancer Res.2020, 40(10):5529-5538.
Related Screening Libraries
|| Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
||NO | NOS | IFN-γ | Antifection|
|Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9. |
|Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]|
METHODS AND RESULTS:
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
|Planta Med. 2004 Jan;70(1):76-8. |
|In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]|
|In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
METHODS AND RESULTS:
Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
Sikokianin C Description
||The roots of Wikstroemia indica.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.