Info: Read More
  • ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  •   
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Science | Nature | Cell | View More
    Natural Products
    Sikokianin C
    Sikokianin C
    Information
    CAS No. 159813-69-1 Price
    Catalog No.CFN96514Purity>=98%
    Molecular Weight556.52Type of CompoundFlavonoids
    FormulaC31H24O10Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Rio de Janeiro State University (Brazil)
  • Monash University Sunway Campus (Malaysia)
  • National Cancer Center Research... (Japan)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Utah State University (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of Lodz (Poland)
  • Kitasato University (Japan)
  • Michigan State University (USA)
  • Wroclaw Medical University (Poland)
  • Korea Food Research Institute(K... (Korea)
  • More...
  • Package
    Featured Products
    Cyanidin-3-O-glucoside chloride

    Catalog No: CFN99740
    CAS No: 7084-24-4
    Price: $118/20mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Baicalin

    Catalog No: CFN99111
    CAS No: 21967-41-9
    Price: $40/20mg
    Bruceine D

    Catalog No: CFN90771
    CAS No: 21499-66-1
    Price: $258/10mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $/mg
    Skullcapflavone II

    Catalog No: CFN92216
    CAS No: 55084-08-7
    Price: $318/10mg
    Sibiricaxanthone B

    Catalog No: CFN90644
    CAS No: 241125-81-5
    Price: $238/20mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antimalaric Compound Library
  • Flavonoids Compound Library
  • NOS Inhibitor Library
  • NO Inhibitor Library
  • IFN-γ Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
    Targets: NO | NOS | IFN-γ | Antifection
    In vitro:
    Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9.
    Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]

    METHODS AND RESULTS:
    In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
    CONCLUSIONS:
    This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
    Planta Med. 2004 Jan;70(1):76-8.
    In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]
    In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
    METHODS AND RESULTS:
    Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
    CONCLUSIONS:
    This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
    Sikokianin C Description
    Source: The roots of Wikstroemia indica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Sibiricose A4

    Catalog No: CFN95298
    CAS No: 241125-73-5
    Price: $318/5mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Quercetin 3-O-beta-D-glucosyl-(1->...

    Catalog No: CFN95277
    CAS No: 143016-74-4
    Price: $318/10mg
    2-O-cinnamoyl-beta-D-glucose

    Catalog No: CFN95111
    CAS No: N/A
    Price: $218/5mg
    Pueroside B

    Catalog No: CFN95141
    CAS No: 100692-54-4
    Price: $288/10mg
    Parvisoflavanone

    Catalog No: CFN95077
    CAS No: 49776-79-6
    Price: $413/5mg
    9,11-Dehydro-beta-boswellic acid

    Catalog No: CFN95335
    CAS No: 471-65-8
    Price: $318/5mg
    Suspenoidside B

    Catalog No: CFN95071
    CAS No: 2161432-08-0
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7969 mL 8.9844 mL 17.9688 mL 35.9376 mL 44.922 mL
    5 mM 0.3594 mL 1.7969 mL 3.5938 mL 7.1875 mL 8.9844 mL
    10 mM 0.1797 mL 0.8984 mL 1.7969 mL 3.5938 mL 4.4922 mL
    50 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.7188 mL 0.8984 mL
    100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3594 mL 0.4492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.