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    Natural Products
    Sikokianin C
    Sikokianin C
    Information
    CAS No. 159813-69-1 Price
    Catalog No.CFN96514Purity>=98%
    Molecular Weight556.52Type of CompoundFlavonoids
    FormulaC31H24O10Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Sikokianin C

    Sikokianin C
    Product Name Sikokianin C
    CAS No.: 159813-69-1
    Catalog No.: CFN96514
    Molecular Formula: C31H24O10
    Molecular Weight: 556.52 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: NO | NOS | IFN-纬 | Antifection
    Source: The roots of Wikstroemia indica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Molecules.2019, 24(6):E1155
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antimalaric Compound Library
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  • Biological Activity
    Description: Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
    Targets: NO | NOS | IFN-γ | Antifection
    In vitro:
    Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9.
    Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]

    METHODS AND RESULTS:
    In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
    CONCLUSIONS:
    This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
    Planta Med. 2004 Jan;70(1):76-8.
    In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]
    In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
    METHODS AND RESULTS:
    Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
    CONCLUSIONS:
    This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
    Sikokianin C Description
    Source: The roots of Wikstroemia indica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7969 mL 8.9844 mL 17.9688 mL 35.9376 mL 44.922 mL
    5 mM 0.3594 mL 1.7969 mL 3.5938 mL 7.1875 mL 8.9844 mL
    10 mM 0.1797 mL 0.8984 mL 1.7969 mL 3.5938 mL 4.4922 mL
    50 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.7188 mL 0.8984 mL
    100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3594 mL 0.4492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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