ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Antiviral Res.2013, 98(3):386-93J-STAGE2015, 249-255Acta Biochim Pol.2015, 62(2):253-8Molecules.2016, 21(6)ARPN Journal of Eng.& Applied Sci...2016...Vojnosanit Pregl2016, 75(00):391-391J.Acta Agriculturae Scandinavica...2017...Front Plant Sci.2017, 8:723
Journal of Third Military Medical...2018...Mol Cells.2018, 41(8):771-780Clin Transl Oncol.2019, 10.1007Journal of Ginseng Research...2019...Pharmacognosy Journal...2019...BMC Complement Altern Med....2019...BMC Complement Altern Med....2019...Food Chem.2019, 274:345-350
Plos One.2019, 15(2):e0220084Planta Med.2019, 85(3):217-224Biomedicine & Pharmacotherapy...2020...Advances in Traditional Medicine...2020...Anal Bioanal Chem....2020...SCOPUS.2020, 836-847.Naunyn Schmiedebergs Arch Pharmac...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Rio de Janeiro State University (Brazil)Monash University Sunway Campus (Malaysia)National Cancer Center Research... (Japan)Fraunhofer-Institut für Moleku... (Germany)
Utah State University (USA)Centrum Menselijke Erfelijkheid (Belgium)University of Lodz (Poland)Kitasato University (Japan)
Michigan State University (USA)Wroclaw Medical University (Poland)Korea Food Research Institute(K... (Korea)
Related Screening Libraries
|| Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
||NO | NOS | IFN-γ | Antifection|
|Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9. |
|Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]|
METHODS AND RESULTS:
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
|Planta Med. 2004 Jan;70(1):76-8. |
|In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]|
|In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
METHODS AND RESULTS:
Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
Sikokianin C Description
||The roots of Wikstroemia indica.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.