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More articles cited ChemFaces products.
Free Radic Biol Med.2021, 166:104-115.J Clin Med.2022, 11(13):3662.J Vet Sci.2020, 21(3):e39.Environ Toxicol.2021, 36(9):1848-1856.Int J Mol Med.2019, 43(6):2516-2522Current Pharmaceutical Analysis...2017...Phytochem Anal.2013, 24(5):493-503Foods.2021, 10(11):2627.
Planta Med.2019, 85(3):217-224J Cell Biochem.2018, 119(2):2231-2239J Nat Prod.2015, 78(6):1339-4Asian Pac J Cancer Prev. ...2020...Int Immunopharmacol.2019, 71:22-31Nutrients.2021, 13(3):978. J Sci Food Agric.2023, 103(1):213-220.Phytomedicine2022, 104:154337.
Plants (Basel).2020, 9(11):1422.J Nat Prod.2018, 81(4):966-975Life (Basel).2022, 12(12):2107. Journal of Ginseng Research...2021...Environ Toxicol.2019, 34(12):1354-1362Pharmacognosy Journal...2019...Journal of Life Science2017, 233-240
Our products had been exported to the following research institutions and universities, And still growing.
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University of Medicine and Phar... (Romania)Nanjing University of Chinese M... (China)University of Queensland (Australia)Stanford University (USA)
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Front Endocrinol (Lausanne).2020, 11:568436.J Ethnopharmacol.2017, 198:87-90J Pain Res.2022, 15:3469-3478.United States Patent Application2020, 20200038363Microb Pathog.2019, 131:128-134J of Engineering Science&Technology2018, 13(9):2820-2828Molecules.2017, 22(11)Anal Bioanal Chem.2020, 412(12):3005-3015.Food Chem. 2020, 320:126530Korean Herb. Med. Inf.2021, 9(2):231-239.
Related Screening Libraries
||Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds. It has potent anti-inflammatory, anti-proliferation, and pro- apoptosis activities, it also possesses antipyretic activity, similar to acetylsalicylic acid. |
||PARP | Bcl-2/Bax | Caspase | IAP|
|Biol Pharm Bull. 2007 Jul;30(7):1317-23. |
|Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.[Pubmed: 17603173]|
|Beta-Sitosterol is the main dietary phytosterol found in plants and has been shown to inhibit proliferation and induce apoptosis in human solid tumors such as colon and breast cancers. However, the mechanism by which Beta-Sitosterol induces apoptosis is not completely understood in leukemic cells.
METHODS AND RESULTS:
This study investigated the mechanism of apoptosis induced by Beta-Sitosterol in human leukemic U937 cells. Beta-Sitosterol induced cytotoxicity and apoptosis in U937 cells in a concentration dependent manner, as measured by hemocytometer counts, fluorescence microscopy, agarose gel electrophoresis, and flow cytometry analysis. The increase in apoptosis induced by Beta-Sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3. Beta-Sitosterol induced apoptosis was not associated with changes in the expression of Bcl-xL, Bax, or inhibitor of apoptosis proteins (IAPs). z-DEVD-fmk, a caspase-3 specific inhibitor, blocked caspase-3 activation and PARP degradation, and significantly attenuated Beta-Sitosterol-induced apoptosis. This suggests that caspase-3 activation is partially essential for Beta-Sitosterol-induced apoptosis. Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by Beta-Sitosterol, and effectively attenuated the apoptotic response to Beta-Sitosterol.
These results show that Beta-Sitosterol potently induces apoptosis in U937 cells and that Beta-Sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.
|Angiogenesis. 1999;3(2):117-23. |
|A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol.[Pubmed: 14517429]|
|Aloe vera gel has a beneficial effect on wound healing. Because angiogenesis is an essential process in wound healing, we hypothesized that Aloe vera gel might contain potent angiogenic compounds.
METHODS AND RESULTS:
Here we demonstrate that Aloe vera gel and its extracts are angiogenic on the chorioallantoic membrane (CAM) of chick embryo. Out of the three compounds purified from the final fraction of Aloe vera gel, Beta-Sitosterol showed a potent angiogenic activity in the CAM assay. In the presence of heparin, Beta-Sitosterol stimulated neovascularization in the mouse Matrigel plug assay and the motility of human umbilical vein endothelial cells in an in vitro wound migration assay.
Thus Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds.
|Nutr Cancer . 2015;67(8):1214-20 |
|Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer[Pubmed: 26473555]|
|All the currently available cancer therapeutic options are expensive but none of them are safe. However, traditional plant-derived medicines or compounds are relatively safe. One widely known such compound is Beta-Sitosterol (BS), a plant derived nutrient with anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia. Studies have shown that BS interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation. Most of the studies are incomplete partly due to the fact that BS is relatively less potent. But the fact that it is generally considered as nontoxic, the opposite of all currently available cancer chemo-therapeutics, is missed by almost all research communities. To offset the lower efficacy of BS, designing BS delivery for "cancer cell specific" therapy hold huge potential. Delivery of BS through liposome is one of such demonstrations that has shown to be highly promising. But further research did not progress neither in the field of drug delivery of BS nor in the field on how BS mediated anticancer activities could be improved, thus making BS an orphan nutraceutical. Therefore, extensive research with BS as potent anticancer nutraceutical is highly recommended.|
|Planta Med. 1980 Jun;39(2):157-63. |
|Anti-inflammatory and antipyretic activities of beta-sitosterol[Reference: WebLink]|
METHODS AND RESULTS:
The anti-inflammatory and antipyretic activities of Beta-Sitosterol , isolated from the plant CYPERUS ROTUNDUS has been studied, employing carrageenin induced oedema, cotton pellet implantation and Brewer's yeast induced pyrexia in rats. Beta-Sitosterol was found to possess potent anti-inflammatory activity against both the tests, similar to hydrocortisone and oxyphenbutazone when administered intraperitoneally. Moreover, it was also orally effective against carrageenin induced oedema. The antiinflammatory activity of Beta-Sitosterol was independent of pituitary adrenal axis. Beta-Sitosterol also possessed antipyretic activity, similar to acetylsalicylic acid. However, it was devoid of analgesic activity against aconitine induced writhing in mice. Beta-Sitosterol showed a wide margin of safety since the approximate LD 50 was more than 3 g/kg i.p. in mice and minimum ulcerogenic dose was 600 mg/kg i.p. in rats.
The presence of the anti-inflammatory and antipyretic activities with wide margin of safety, Beta-Sitosterol may be of therapeutic value.
||The herbs of Anemone cathayensis Kitag.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Int J Oncol. 2003 Dec;23(6):1657-62. |
|Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells.[Pubmed: 14612938]|
|Beta-Sitosterol, a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer.
METHODS AND RESULTS:
The purpose of the present study was to examine the effect of Beta-Sitosterol on the growth of HT116 human colon cancer cells. Treatment with Beta-Sitosterol resulted in a dose-dependent growth inhibition coupled with the characteristic morphological features of apoptosis and with the increase of a sub-G1 cell population. Apoptosis-inducing concentrations of Beta-Sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase. In addition, Beta-Sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol. Beta-Sitosterol treatment also inhibited the expression of cIAP-1 without significant changes in the level of cIAP-2.
Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of Beta-Sitosterol.