Sodium taurochenodeoxycholate | CAS:6009-98-9

Sodium taurochenodeoxycholate

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Description:

Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of β-cells and enhance cytosolic Ca(2+) concentration ([Ca(2+)](c)).

Targets:

ATPase | Potassium Channel | Calcium Channel

In vitro:

Diabetes. 2012 Jun;61(6):1479-89.

Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.[Pubmed: 22492528 ]

Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic β-cells contribute to BA-dependent regulation of glucose homeostasis.
METHODS AND RESULTS:
Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively. Sodium taurochenodeoxycholate (TCDC) increased glucose-induced insulin secretion. This effect was mimicked by the FXR agonist GW4064 and suppressed by the FXR antagonist guggulsterone. TCDC and GW4064 stimulated the electrical activity of β-cells and enhanced cytosolic Ca(2+) concentration ([Ca(2+)](c)). These effects were blunted by guggulsterone. Sodium ursodeoxycholate, which has a much lower affinity to FXR than TCDC, had no effect on [Ca(2+)](c) and insulin secretion. FXR activation by TCDC is suggested to inhibit K(ATP) current. The decline in K(ATP) channel activity by TCDC was only observed in β-cells with intact metabolism and was reversed by guggulsterone. TCDC did not alter insulin secretion in islets of SUR1-KO or FXR-KO mice. TCDC did not change islet cell apoptosis.
CONCLUSIONS:
This is the first study showing an acute action of BA on β-cell function. The effect is mediated by FXR by nongenomic elements, suggesting a novel link between FXR activation and K(ATP) channel inhibition.

Sodium taurochenodeoxycholate Description

Source:	From bear biliary.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Sodium taurochenodeoxycholate
Price:
CAS No.:	6009-98-9
Catalog No.:	CFN80241
Molecular Formula:	C₂₆H₄₄NNaO₆S
Molecular Weight:	521.68 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	From bear biliary.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library Potassium Channel Inhibitor Library Calcium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9169 mL	9.5844 mL	19.1688 mL	38.3377 mL	47.9221 mL
5 mM	0.3834 mL	1.9169 mL	3.8338 mL	7.6675 mL	9.5844 mL
10 mM	0.1917 mL	0.9584 mL	1.9169 mL	3.8338 mL	4.7922 mL
50 mM	0.0383 mL	0.1917 mL	0.3834 mL	0.7668 mL	0.9584 mL
100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.3834 mL	0.4792 mL

CFN96646	Taurocholic acid	81-24-3	515.70	C₂₆H₄₅NO₇S
CFN96645	Tauroursodeoxycholic acid	14605-22-2	499.70	C₂₆H₄₅NO₆S
CFN80241	Sodium taurochenodeoxycholate	6009-98-9	521.68	C₂₆H₄₄NNaO₆S
CFN96464	Ursodeoxycholic acid	128-13-2	392.58	C₂₄H₄₀O₄
CFN90478	Chenodeoxycholic acid	474-25-9	392.57	C₂₄H₄₀O₄
CFN99796	Cholic acid	81-25-4	408.57	C₂₂H₄₀O₅
CFN91626	Hyocholic acid	547-75-1	408.6	C₂₄H₄₀O₅
CFN99798	Deoxycholic acid	83-44-3	392.57	C₂₄H₄₀O₄
CFN89170	Lithocholic acid	434-13-9	376.58	C₂₄H₄₀O₃
CFN96673	Sodium cholate	361-09-1	430.55	C₂₄H₃₉NaO₅