Science | Nature | Cell | View More
Natural Products
Isorubrofusarin 10-gentiobioside
Isorubrofusarin 10-gentiobioside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isorubrofusarin 10-gentiobioside
Price: $338 / 10mg
CAS No.: 200127-93-1
Catalog No.: CFN95119
Molecular Formula: C27H32O15
Molecular Weight: 596.5 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The seeds of Cassia obtusifolia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $243.4 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Donald Danforth Plant Science C... (USA)
  • Shanghai Institute of Biochemis... (China)
  • University of Dicle (Turkey)
  • University of Toronto (Canada)
  • Universidade do Porto (Portugal)
  • Florida International University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Wroclaw Medical University (Poland)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Sant Gadge Baba Amravati Univer... (India)
  • Utah State University (USA)
  • More...
Package
Featured Products
Cyanidin-3-O-rutinoside chloride

Catalog No: CFN92135
CAS No: 18719-76-1
Price: $298/10mg
Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/5mg
Jatrorrhizine

Catalog No: CFN98493
CAS No: 3621-38-3
Price: $60/20mg
Moschamine

Catalog No: CFN94006
CAS No: 68573-23-9
Price: $218/5mg
(+)-Lyoniresinol 9'-O-glucoside

Catalog No: CFN97964
CAS No: 87585-32-8
Price: $318/10mg
Isorhamnetin-3-O-beta-D-Glucoside

Catalog No: CFN99757
CAS No: 5041-82-7
Price: $218/10mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Vitexin 2''-glucoside

Catalog No: CFN70421
CAS No: 61360-94-9
Price: $ / mg
Moracin D

Catalog No: CFN97179
CAS No: 69120-07-6
Price: $ /
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
Targets: AChR | BACE
In vitro:
Molecules. 2017 Dec 28;23(1). pii: E69.
Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia.[Pubmed: 29283428]
Cassia obtusifolia Linn. have been used to improve vision, inflammatory diseases, and as hepatoprotective agents and to promote urination from ancient times.
METHODS AND RESULTS:
In the present study, we investigated the influence of glycosylation of components of C. obtusifolia and structure-activity relationships (SARs) with respect to the inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), which are related to Alzheimer's disease (AD). All six C. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside ( Isorubrofusarin 10-gentiobioside, 5), and rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1. Compounds 3 and 4 showed most significant inhibition against AChE and BACE1, respectively. The SARs results emphasized the importance of gentiobiosyl moiety in the rubrofusarin for AChE inhibition, whereas the presence of hydroxyl group at C-8 and the glucosyl moiety at the C-6 position in the nor-rubrofusarin appeared to largely determine BACE1 inhibition. Kinetics and docking studies showed the lowest binding energy and highest affinity for mixed-type inhibitors, 3 and 4. Hydrophobic bonds interactions and the number of hydrogen bonds determined the strength of the protein-inhibitor interaction.
CONCLUSIONS:
These results suggest that C. obtusifolia and its constituents have therapeutic potential, and that the SARs of its active components are further explored with a view towards developing a treatment for AD.
Isorubrofusarin 10-gentiobioside Description
Source: The seeds of Cassia obtusifolia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3-O-[5'''-O-feruloyl-beta-D-apiofu...

Catalog No: CFN95154
CAS No: 148210-00-8
Price: $413/5mg
New compound 13

Catalog No: CFN95374
CAS No: N/A
Price: $318/5mg
4-O-Caffeoyl-3-O-syringoylquinic a...

Catalog No: CFN95430
CAS No: 1207645-17-7
Price: $413/5mg
Dehydrojuncusol

Catalog No: CFN95143
CAS No: 117824-04-1
Price: $318/5mg
11-Keto-ganoderic acid DM

Catalog No: CFN95593
CAS No: N/A
Price: $413/5mg
Yuanhuanin

Catalog No: CFN95127
CAS No: 83133-14-6
Price: $318/5mg
N1,N5,N10-(Z)-tri-p-coumaroylsperm...

Catalog No: CFN95253
CAS No: 131086-78-7
Price: $238/5mg
Gambogoic acid A

Catalog No: CFN95439
CAS No: 887923-49-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6764 mL 8.3822 mL 16.7645 mL 33.5289 mL 41.9111 mL
5 mM 0.3353 mL 1.6764 mL 3.3529 mL 6.7058 mL 8.3822 mL
10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3529 mL 4.1911 mL
50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6706 mL 0.8382 mL
100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Cyanidin-3-O-rutinoside chloride

Catalog No: CFN92135
CAS No: 18719-76-1
Price: $298/10mg
Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/5mg
Jatrorrhizine

Catalog No: CFN98493
CAS No: 3621-38-3
Price: $60/20mg
Moschamine

Catalog No: CFN94006
CAS No: 68573-23-9
Price: $218/5mg
(+)-Lyoniresinol 9'-O-glucoside

Catalog No: CFN97964
CAS No: 87585-32-8
Price: $318/10mg
Isorhamnetin-3-O-beta-D-Glucoside

Catalog No: CFN99757
CAS No: 5041-82-7
Price: $218/10mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Vitexin 2''-glucoside

Catalog No: CFN70421
CAS No: 61360-94-9
Price: $ / mg
Moracin D

Catalog No: CFN97179
CAS No: 69120-07-6
Price: $ /
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Tags: buy Isorubrofusarin 10-gentiobioside | Isorubrofusarin 10-gentiobioside supplier | purchase Isorubrofusarin 10-gentiobioside | Isorubrofusarin 10-gentiobioside cost | Isorubrofusarin 10-gentiobioside manufacturer | order Isorubrofusarin 10-gentiobioside | Isorubrofusarin 10-gentiobioside distributor