Sprengerinin C | CAS:88861-91-0 | Manufacturer ChemFaces

Sprengerinin C

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Sprengerinin C Description

Source:	The tubers of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Eur J Pharmacol. 2013 Aug 15;714(1-3):261-73.

Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.[Pubmed: 23684542 ]

The multi-targeted therapy for liver cancer has been considered as a novel strategy to fight hepatocellular carcinoma.
METHODS AND RESULTS:
In this study, we first found that Sprengerinin C, a naturally derived compound strongly suppressed tumor angiogenesis in human umbilical vein endothelial cells. A mechanism study revealed that Sprengerinin C blocked vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways, two major pathways for tumor angiogenesis. Moreover, Sprengerinin C inhibited vascular endothelial growth factor release, a vital event for early angiogenesis response, from hypoxic HepG-2/BEL7402 cells by suppressing hypoxia-inducible factor-1α transcriptional activity. Furthermore, Sprengerinin C induced HepG-2/BEL7402 cell apoptosis by activating NADPH oxidase/reactive oxygen species-dependent caspase apoptosis pathway and suppressed HepG-2/BEL7402 cell growth through p53-mediated G2/M-phase arrest. Sprengerinin C also showed a significant anti-tumor effect in the nude mouse xenograft model of human hepatocellular carcinoma.
CONCLUSIONS:
These results provide new insights into development of potent candidate compounds for liver cancer through affecting multiple tumor progression steps of angiogenesis, apoptosis and proliferation.

Structure Identification:

Chinese Journal of Organic Chemistry,2008,8(9):1620-3.

Structural elucidation of steroidal glycosides from Ophiopogon japonicus[Reference: WebLink]

METHODS AND RESULTS:
A new steroidal 14-hydroxy Sprengerinin C(1) was isolated from the tuber of Ophiopogon ja-ponicus(Thunb.) Ker-Gawl.,along with three known compounds,Sprengerinin C(2) ,ophiogenin-3-O-α-L-rhamnopyranosyl-(1→2) -β-D-glucopyranoside(3) and β-sitosterol-β-D-glucopyranoside(4) . Their struc-tures were established on the basis of IR,HR-MS,1D and 2D-NMR analyses,as well as by literature com-parison of spectroscopic data.

Product Name	Sprengerinin C
Price:
CAS No.:	88861-91-0
Catalog No.:	CFN96366
Molecular Formula:	C₄₄H₇₀O₁₆
Molecular Weight:	855.0 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The tubers of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Antiangiogenic Compound Library Pro-apoptotic Compound Library Steroids Compound Library VEGFR Inhibitor Library ROS Inhibitor Library PI3K Inhibitor Library p53 Inhibitor Library p38MAPK Inhibitor Library NADPH-oxidase Inhibitor Library mTOR Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1696 mL	5.848 mL	11.6959 mL	23.3918 mL	29.2398 mL
5 mM	0.2339 mL	1.1696 mL	2.3392 mL	4.6784 mL	5.848 mL
10 mM	0.117 mL	0.5848 mL	1.1696 mL	2.3392 mL	2.924 mL
50 mM	0.0234 mL	0.117 mL	0.2339 mL	0.4678 mL	0.5848 mL
100 mM	0.0117 mL	0.0585 mL	0.117 mL	0.2339 mL	0.2924 mL

CFN70451	Tribulosin	79974-46-2	1151.3	C₅₅H₉₀O₂₅
CFN92831	Digitonin	11024-24-1	1229.3	C₅₆H₉₂O₂₉
CFN99954	Polyphyllin VI	55916-51-3	738.91	C₃₉H₆₂O₁₃
CFN99055	Mannioside A	1038922-95-0	738.9	C₃₉H₆₂O₁₃
CFN90638	Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	128502-94-3	754.9	C₃₉H₆₂O₁₄
CFN70458	Shatavarin IV	84633-34-1	887.1	C₄₅H₇₄O₁₇
CFN90636	14-Hydroxy sprengerinin C	1111088-89-1	871.02	C₄₄H₇₀O₁₇
CFN90614	17-Hydroxy sprengerinin C	1029017-75-1	871.02	C₄₄H₇₀O₁₇
CFN96366	Sprengerinin C	88861-91-0	855.0	C₄₄H₇₀O₁₆
CFN96364	2''-O-Acetylsprengerinin C	1220707-33-4	897.1	C₄₆H₇₂O₁₇