Suchilactone | CAS:50816-74-5 Manufacturer ChemFaces

Suchilactone

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Size /Price /Stock	10 mM * 1 mL in DMSO / $287.3 / In-stock
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Description:

Suchilactone may have the potential to be developed as a treatment of Alzheimer's Disease.

Targets:

Beta Amyloid

In vivo:

J Agric Food Chem. 2017 Apr 19;65(15):3133-3140.

Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.[Pubmed: 28378593 ]

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurotoxic β-amyloid (Aβ) peptides, which consequently affects cognitive decline and memory impairment. Current research on AD treatment is actively focusing on the prevention of neurotoxic Aβ peptide accumulation. Monsonia angustifolia is reported to be consumed as an indigenous vegetable in Tanzania.
METHODS AND RESULTS:
In this study, we investigated the effect of the ethanol (EtOH) extract of M. angustifolia dried ground material on Aβ production and spatial learning ability as protection against AD. The formation of Aβ peptides was significantly reduced in HeLa cells stably transfected with the Swedish mutant form of β-amyloid precursor protein (APPsw) after treatment with a 60% EtOH extract of M. angustifolia. We next examined the cognitive-improving effects of the EtOH extract in vivo. Tg2576 mice were treated with extract for 6 months and subjected to Morris water maze and novel object recognition tests. The results showed that the 60% EtOH extract of M. angustifolia significantly ameliorated behavioral deficits of the AD transgenic mice and reduced the level of insoluble Aβ42 in the cerebral cortex and hippocampus. We further found that the 60% EtOH extract was effective for memory function recovery after shorter treatment (4 months). In addition, we isolated and identified several single compounds, justicidin A, 5-methoxyjusticidin A, chinensinaphthol, retrochinensinaphthol methyl ether, and Suchilactone, from M. angustifolia and tested these compounds.
CONCLUSIONS:
Among them, justicidin A potently decreased the formation of Aβ in APPsw-transfected cells. These data suggest that the 60% EtOH extract of M. angustifolia has the potential to be developed as a treatment of AD. Furthermore, justicidin A may contribute, at least partially, to the Aβ alteration observed with the extract treatment.

Suchilactone Description

Source:	The herbs of Haplophyllum pedicellatum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	50816-74-5	Price	$338 / 5mg
Catalog No.	CFN95010	Purity	>=98%
Molecular Weight	368.4	Type of Compound	Lignans
Formula	C₂₁H₂₀O₆	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library Beta Amyloid Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7144 mL	13.5722 mL	27.1444 mL	54.2888 mL	67.861 mL
5 mM	0.5429 mL	2.7144 mL	5.4289 mL	10.8578 mL	13.5722 mL
10 mM	0.2714 mL	1.3572 mL	2.7144 mL	5.4289 mL	6.7861 mL
50 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.0858 mL	1.3572 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5429 mL	0.6786 mL

CFN95224	Isolappaol A	131400-96-9	536.6	C₃₀H₃₂O₉
CFN95242	Lappaol B	62359-60-8	550.6	C₃₁H₃₄O₉
CFN95068	Lappaol C	64855-00-1	554.6	C₃₀H₃₄O₁₀
CFN95225	Isolappaol C	929905-15-7	554.6	C₃₀H₃₄O₁₀
CFN95069	Lappaol F	69394-17-8	714.8	C₄₀H₄₂O₁₂
CFN96715	(+)-Matairesinol	148409-36-3	358.39	C₂₀H₂₂O₆
CFN96234	Isosalicifolin	156974-99-1	356.4	C₂₀H₂₀O₆
CFN98454	Nortrachelogenin	34444-37-6	374.4	C₂₀H₂₂O₇
CFN96714	(+)-Nortrachelogenin	61521-74-2	374.38	C₂₀H₂₂O₇
CFN89300	(7R)-Methoxy-8-epi-matairesinol	198827-23-5	388.41	C₂₁H₂₄O₇