ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Suchilactone
Citing Use of our Products
How to Order
Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $287.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules.2020, 25(23):5636.Mol Pharm.2017, 14(9):3164-3177South African Journal of Botany...2021...Int J Mol Sci.2021, 22(9):5012.J Bone Miner Res.2017, 32(12):2415-2430Nutr Res Pract.2020, 14(5):478-489.Korean J of Crop Science2019, 452-458Applied Biological Chem. 2020, 26(63).
Nutrients.2019, 11(11):E2694The Malaysian journal of patholog...2019...Pharmacognosy Journal, 2021, 13(5).Evid-Based Compl Alt2020, 7202519:13Front Plant Sci.2018, 9:1424Nutr Res Pract2019, 13:e45Asian Journal of Chemistry...2014...Comput Biol Chem.2019, 83:107096
Antioxidants (Basel).2020, 9(2):E99Exp Parasitol.2018, 194:67-78Front Pharmacol.2021, 12:744624.Enzyme Microb Technol....2022...J Pharm Biomed Anal.2017, 140:274-280Nutrients.2021, 13(3):978. Primary and Industrial.2018, 52(11)
More...
Our products had been exported to the following research institutions and universities, And still growing.
VIT University (India)University of Amsterdam (Netherlands)Institute of Tropical Disease U... (Indonesia)Cornell University (USA)
Universidade de Franca (Brazil)Texas A&M University (USA)National Cancer Center Research... (Japan)Sapienza University of Rome (Italy)
Universidad de Ciencias y Artes... (Mexico)Molecular Biology Institute of ... (Spain)University of Hawaii Cancer Center (USA)
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Suchilactone
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Appl. Sci.2020, 10(23), 8729Eur J Pharm Sci.2016, 94:33-45Food Research International2016, 106-113BMC Complement Altern Med.2016, 16:213Sci Rep.2017, 7(1):3249Asian Pac J Cancer Prev.2021, 22(S1):97-106.J-STAGE2015, 249-255Pharmaceutics.2021, 13(2):187. Mol Cells.2015, 38(9):765-72University of Limpopo2016, 1777
Related Screening Libraries
| Description: |
Suchilactone may have the potential to be developed as a treatment of Alzheimer's Disease. |
| Targets: |
Beta Amyloid |
| In vivo: |
| J Agric Food Chem. 2017 Apr 19;65(15):3133-3140. | | Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.[Pubmed: 28378593 ] | Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurotoxic β-amyloid (Aβ) peptides, which consequently affects cognitive decline and memory impairment. Current research on AD treatment is actively focusing on the prevention of neurotoxic Aβ peptide accumulation. Monsonia angustifolia is reported to be consumed as an indigenous vegetable in Tanzania.
METHODS AND RESULTS:
In this study, we investigated the effect of the ethanol (EtOH) extract of M. angustifolia dried ground material on Aβ production and spatial learning ability as protection against AD. The formation of Aβ peptides was significantly reduced in HeLa cells stably transfected with the Swedish mutant form of β-amyloid precursor protein (APPsw) after treatment with a 60% EtOH extract of M. angustifolia. We next examined the cognitive-improving effects of the EtOH extract in vivo. Tg2576 mice were treated with extract for 6 months and subjected to Morris water maze and novel object recognition tests. The results showed that the 60% EtOH extract of M. angustifolia significantly ameliorated behavioral deficits of the AD transgenic mice and reduced the level of insoluble Aβ42 in the cerebral cortex and hippocampus. We further found that the 60% EtOH extract was effective for memory function recovery after shorter treatment (4 months). In addition, we isolated and identified several single compounds, justicidin A, 5-methoxyjusticidin A, chinensinaphthol, retrochinensinaphthol methyl ether, and Suchilactone, from M. angustifolia and tested these compounds.
CONCLUSIONS:
Among them, justicidin A potently decreased the formation of Aβ in APPsw-transfected cells. These data suggest that the 60% EtOH extract of M. angustifolia has the potential to be developed as a treatment of AD. Furthermore, justicidin A may contribute, at least partially, to the Aβ alteration observed with the extract treatment. |
|
Suchilactone Description
| Source: |
The herbs of Haplophyllum pedicellatum. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7144 mL |
13.5722 mL |
27.1444 mL |
54.2888 mL |
67.861 mL |
| 5 mM |
0.5429 mL |
2.7144 mL |
5.4289 mL |
10.8578 mL |
13.5722 mL |
| 10 mM |
0.2714 mL |
1.3572 mL |
2.7144 mL |
5.4289 mL |
6.7861 mL |
| 50 mM |
0.0543 mL |
0.2714 mL |
0.5429 mL |
1.0858 mL |
1.3572 mL |
| 100 mM |
0.0271 mL |
0.1357 mL |
0.2714 mL |
0.5429 mL |
0.6786 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
