Tenacissoside H | CAS:191729-45-0 | Manufacturer ChemFaces

Tenacissoside H

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Description:

Tenacissoside H has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.

Targets:

PI3K | NF-kB | PI3K | Akt

In vivo:

Evid Based Complement Alternat Med. 2015; 2015: 464937.

Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade[Pubmed: 26495015]

The purpose of the study was to elucidate the molecular mechanism of Tenacissoside H (TDH) inhibiting esophageal carcinoma infiltration and proliferation.
METHODS AND RESULTS:
In vitro, EC9706 cells were treated with TDH. Cells proliferation and cell cycle were assayed. PI3K and NF-κB mRNAs expression were determined by real time PCR. In vivo, model of nude mice with tumor was established. Mice were treated with TDH. Inhibition ratio of tumor volume was calculated. PCNA expression was examined. Protein expression in PI3K/Akt-NF-κB signaling pathway was determined. In vitro, TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). In vivo, TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05).
CONCLUSIONS:
TDH inhibited esophageal carcinoma infiltration and proliferation both in vitro and in vivo. The anticancer activity has relation to arresting the cell cycle at the S phase, inhibited the PCNA expression of transplanted tumors in nude mice, and regulated the protein expression in the PI3K/Akt-NF-κB transduction cascade.

Tenacissoside H Description

Source:	The herbs of Marsdenia tenacissima
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2083-6.

Determination of tenacissoside H in Marsdeniae tenacissimae by HPLC-ELSD.[Pubmed: 21046734]

METHODS AND RESULTS:
In order to improve the quality standard of Marsdenia tenacissima, a quantitative determination method of Tenacissoside H was developed using high performance liquid chromatography. The method was carried out on a YMC ODS-H80 (4.6 mm x 250 mm, 4 microm) column eluted with a mixture of acetonitrile and water (50:50) as the mobile phase. The flow rate was 0.8 mL x min(-1) and the column temperature was 35 degrees C. An evaporative light scattering detector (ELSD) was used with the temperature of drift tube set at 60 degrees C and the gas flow rate of nitrogen set at 1.5 mL x min(-1). The calibration curve was linear in the range from 0.5625 to 36.00 microg (r = 0.9998). The average recovery and RSD were 99.41% and 1.8%, respectively. The contents of Tenacissoside H in the 11 samples from different habitats varied from 0.201% to 0.862%.
CONCLUSIONS:
The method established in this paper is specific and reliable to control and evaluate the quality of M. tenacissima.

Product Name	Tenacissoside H
Price:	$90 / 20mg
CAS No.:	191729-45-0
Catalog No.:	CFN90428
Molecular Formula:	C₄₂H₆₆O₁₄
Molecular Weight:	794.97 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Marsdenia tenacissima
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Steroids Compound Library PI3K Inhibitor Library NF-kB Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2579 mL	6.2895 mL	12.5791 mL	25.1582 mL	31.4477 mL
5 mM	0.2516 mL	1.2579 mL	2.5158 mL	5.0316 mL	6.2895 mL
10 mM	0.1258 mL	0.629 mL	1.2579 mL	2.5158 mL	3.1448 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.5032 mL	0.629 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.2516 mL	0.3145 mL

CFN96087	Dregeoside A11	89020-11-1	1101.3	C₅₅H₈₈O₂₂
CFN89225	Otophylloside B 4'''-O-alpha-L-cymaropyranoside	171422-82-5	1067.31	C₅₆H₉₀O₁₉
CFN89237	Otophylloside B 4'''-O-beta-D-cymaropyranoside	171422-85-8	1067.31	C₅₆H₉₀O₁₉
CFN89226	Otophylloside B 4'''-O-beta-D-oleandropyranoside	168001-54-5	1067.31	C₅₆H₉₀O₁₉
CFN89036	Otophylloside O	1326583-08-7	1077.25	C₅₆H₈₄O₂₀
CFN96784	Cynatratoside A	97399-96-7	504.62	C₂₈H₄₀O₈
CFN96787	Glaucogenin C mono-D-thevetoside	849201-84-9	520.61	C₂₈H₄₀O₉
CFN95299	Glaucoside A	81474-91-1	520.2	C₂₈H₄₀O₉
CFN95300	Glaucoside C	81474-89-7	794.9	C₄₁H₆₂O₁₅
CFN91815	Cynanoside F	1800029-50-8	794.9	C₄₁H₆₂O₁₅