Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Rhamnocitrin
    Information
    CAS No. 569-92-6 Price
    Catalog No.CFN97724Purity>=98%
    Molecular Weight300.27Type of CompoundFlavonoids
    FormulaC16H12O6Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Melbourne (Australia)
  • Chiang Mai University (Thailand)
  • Uniwersytet Gdański (Poland)
  • University of Queensland (Australia)
  • The Australian National University (Australia)
  • Chang Gung University (Taiwan)
  • University of Medicine and Phar... (Romania)
  • University of Toulouse (France)
  • The Ohio State University (USA)
  • University of Vigo (Spain)
  • Kyoto University (Japan)
  • More...
  • Package
    Featured Products
    1,5-Dicaffeoylquinic acid

    Catalog No: CFN99123
    CAS No: 30964-13-7
    Price: $238/20mg
    Salvigenin

    Catalog No: CFN99883
    CAS No: 19103-54-9
    Price: $338/10mg
    Sibiricose A5

    Catalog No: CFN90645
    CAS No: 107912-97-0
    Price: $138/20mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    alpha-Amyrin

    Catalog No: CFN92377
    CAS No: 638-95-9
    Price: $318/5mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $488/5mg

    Rhamnocitrin

    Rhamnocitrin
    Product Name Rhamnocitrin
    CAS No.: 569-92-6
    Catalog No.: CFN97724
    Molecular Formula: C16H12O6
    Molecular Weight: 300.27 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: HO-1 | ERK | MEK | p38MAPK | Immunology & Inflammation related
    Source: The rhizomes of Alpinia officinarum Hance.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Food Res Int.2018, 106:909-919
  • Biomolecules.2020, 10(2):E184
  • Molecules.2020, 25(9):2081.
  • Mol Immunol. 2016, 78:121-132
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Nat Chem Biol.2018, 14(8):760-763
  • Phytochemistry Letters2017, 449-455
  • Plant Sci.2020, 301:110656.
  • The Korea Society of Pha.2014, 300-314
  • Front Cell Infect Microbiol.2018, 8:292
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Antioxidants Compound Library
  • Immunomodulators Compound Library
  • Anti-Atherosclerotic Compound Library
  • Anti-cataract Compound Library
  • Flavonoids Compound Library
  • p38MAPK Inhibitor Library
  • MEK Inhibitor Library
  • Immunology & Inflammation related Inhibitor Library
  • HO-1 Inhibitor Library
  • ERK Inhibitor Library
  • Biological Activity
    Description: Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune. Rhamnocitrin possesses significant anticataract activity and acts most likely due to its antioxidant property, it shows a significant protection against cloudiness in lenses induced by hydrogen peroxide and hydrocortisone in a dose dependent manner.Rhamnocitrin and kaempferol can augment cellular antioxidant defense capacity, at least in part, through regulation of HO-1 expression and MAPK signal transduction; they not only protect low-density lipoprotein from oxidation but also prevent atherogenesis through suppressing macrophage uptake of oxidized low-density lipoprotein.
    Targets: HO-1 | ERK | MEK | p38MAPK | Immunology & Inflammation related
    In vitro:
    Oriental Pharmacy and Experimental Medicine,2012,12(3):227 -32.
    Anticataract activity of rhamnocitrin isolated from Bauhinia variegata stem bark.[Reference: WebLink]
    A cataract is any clouding or opaque area in the eye’s natural lens, which is normally crystal clear, is the leading cause of blindness worldwide. It accounts for approximately 42% of all blindness. Approximately 25% of the population over 65 and about 50% over 80 age has serious loss of vision because of cataract. Most cataracts progress and eventually hamper vision. Multiple mechanisms have been implicated in the development of cataract. But the exact pathogenesis which leads to opacification is not clearly known. Oxidative damage to the lens has been recognized as the initiating event in the pathogenesis of cataracts.
    METHODS AND RESULTS:
    In cataract, the oxidation-antioxidant equilibrium shift more towards oxidative stress. Accordingly, antioxidants could prove potential anticataract agents. Rhamnocitrin, a flavonoid, possess strong antioxidant effects; can be used effectively to manage the cataract. Therefore, anticataract activity of Rhamnocitrin (10, 20, 40 and 80 μg), isolated from Bauhinia variegata (Leguminosae) stem bark, was studied in ovine and chick embryo lens model. It showed a significant protection against cloudiness in lenses induced by hydrogen peroxide and hydrocortisone in a dose dependent manner.
    CONCLUSIONS:
    The findings suggest that Rhamnocitrin possess significant anticataract activity and act most likely due to its antioxidant property.
    In vivo:
    J Agric Food Chem. 2007 Nov 28;55(24):9969-76.
    Antiatherogenic effects of kaempferol and rhamnocitrin.[Pubmed: 17973448]
    Atherosclerosis is a chronic inflammatory disease of the arterial wall. Kaempferol and Rhamnocitrin (kaempferol 7-O-methyl ether) are two anti-inflammatory flavonoids commonly found in plants. The aim of this study is to investigate the function of kaempferol and Rhamnocitrin on prevention of atherosclerosis.
    METHODS AND RESULTS:
    Chemical analyses demonstrated that kaempferol and Rhamnocitrin were scavengers of DPPH (1,1-diphenyl-2-picrylhydrazyl) with IC50 of 26.10 +/- 1.33 and 28.38 +/- 3.07 microM, respectively. Copper-induced low-density lipoprotein (LDL) oxidation was inhibited by kaempferol and Rhamnocitrin, with similar potency, as measured by decreased formation of malondialdehyde and relative electrophoretic mobility (REM) on agarose gel, while Rhamnocitrin reduced delayed formation of conjugated dienes better than kaempferol. Cholesterol-laden macrophages are the hallmark of atherogenesis. The class B scavenger receptor, CD36, binds oxidized low-density lipoprotein (oxLDL), is found in atherosclerotic lesions, and is up-regulated by oxLDL. Addition of kaempferol and Rhamnocitrin (20 microM) caused significant reductions in cell surface CD36 protein expression in THP-1-derived macrophages (p < 0.05). Reverse transcription quantitative PCR (RT-Q-PCR) showed that kaempferol and Rhamnocitrin (20 microM) decreased oxLDL-induced CD36 mRNA expression (p < 0.01 and p < 0.05, respectively). Kaempferol- and Rhamnocitrin-treated macrophages also showed reduction in 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanide perchlorate (DiI)-labeled oxLDL uptake.
    CONCLUSIONS:
    Current evidences indicate that kaempferol and Rhamnocitrin not only protect LDL from oxidation but also prevent atherogenesis through suppressing macrophage uptake of oxLDL.
    Rhamnocitrin Description
    Source: The rhizomes of Alpinia officinarum Hance.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    (R)-5,3'-Dimethyl hesperidin

    Catalog No: CFN95310
    CAS No: N/A
    Price: $318/5mg
    Glycitein

    Catalog No: CFN99106
    CAS No: 40957-83-3
    Price: $128/20mg
    Tectoruside

    Catalog No: CFN95051
    CAS No: 38784-73-5
    Price: $288/20mg
    Hannokinol

    Catalog No: CFN96248
    CAS No: 79120-40-4
    Price: $368/5mg
    Carlinoside

    Catalog No: CFN90720
    CAS No: 59952-97-5
    Price: $318/5mg
    Perlolyrine

    Catalog No: CFN95291
    CAS No: 29700-20-7
    Price: $413/5mg
    Skullcapflavone II

    Catalog No: CFN92216
    CAS No: 55084-08-7
    Price: $318/10mg
    Magnolignan A

    Catalog No: CFN96188
    CAS No: 93673-81-5
    Price: $388/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3303 mL 16.6517 mL 33.3034 mL 66.6067 mL 83.2584 mL
    5 mM 0.6661 mL 3.3303 mL 6.6607 mL 13.3213 mL 16.6517 mL
    10 mM 0.333 mL 1.6652 mL 3.3303 mL 6.6607 mL 8.3258 mL
    50 mM 0.0666 mL 0.333 mL 0.6661 mL 1.3321 mL 1.6652 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.6661 mL 0.8326 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Toxicol Appl Pharmacol. 2009 May 15;237(1):59-68.
    Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells.[Pubmed: 19265714]
    Oxidative stress has been considered as a major cause of cellular injuries in a variety of clinical abnormalities, especially neural diseases. Our aim of research is to investigate the protective effects and mechanisms of kaempferol and Rhamnocitrin (kaempferol-7-methyl ether) on oxidative damage in rat pheochromocytoma PC12 cells induced by a limited supply of serum and hydrogen peroxide (H2O2).
    METHODS AND RESULTS:
    The current result demonstrated that kaempferol protected PC12 cells from serum deprivation-induced apoptosis. Pretreatment of cells with kaempferol also diminished intracellular generation of reactive oxygen species (ROS) in response to H2O2 and strongly elevated cell viability. RT-Q-PCR and Western blotting revealed that kaempferol and Rhamnocitrin significantly induced heme oxygenase (HO)-1 gene expression. Addition of zinc protoporphyrin (Znpp), a HO-1 competitive inhibitor, significantly attenuated their protective effects in H2O2-treated cells, indicating the vital role of HO-1 in cell resistance to oxidative injury. While investigating the signaling pathways responsible for HO-1 induction, we observed that kaempferol induced sustained extracellular signal-regulated protein kinase 1/2 (ERK1/2) in PC12 cells grown in low serum medium; while Rhamnocitrin only stimulated transient ERK cascade. Addition of U0126, a highly selective inhibitor of MEK1/2, which is upstream of ERK1/2, had no effect on kaempferol- or Rhamnocitrin-induced HO-1 mRNA expression, indicating no direct cross-talk between these two pathways. Furthermore, both kaempferol and Rhamnocitrin were able to persistently attenuate p38 phosphorylation.
    CONCLUSIONS:
    Taking together, the above findings suggest that kaempferol and Rhamnocitrin can augment cellular antioxidant defense capacity, at least in part, through regulation of HO-1 expression and MAPK signal transduction.
    Animal Research:
    Chinese Journal of Information on Traditional Chinese Medicine,2015, 22(5):57-9.
    Effects of Rhamnocitrin in Oxytropis Falcata on Nonspecial Immune Function of Immunosuppressive Mice.[Reference: WebLink]
    To study action mechanism of Rhamnocitrin in Oxytropis Falcata on enhance the immune function.
    METHODS AND RESULTS:
    Kunming mice were randomly divided into blank control group, model group, positive control group, traditional Chinese medicine high, medium, and low dose groups. All treatment groups received gavage with relevant medicine for 10 days. From the 8th day, blank control group received intraperitoneal injection with normal saline, while other groups received intraperitoneal injection with cyclophosphamide for 3 days. Through macrophages carbon clearance test, macrophage phagocytosis of chicken erythrocytes test, and immunosuppressive mice organ index detection, effects of Rhamnocitrin in Oxytropis Falcata on nonspecific immune function of immunosuppressive mice were observed. Compared with model group and blank control group, traditional Chinese medicine high, medium, and low dose groups could improve the phagocytic activity of immunosuppressive mice, clearance index, and phagocytic coefficient(P 0.05), and increase the organ index of the thymus and spleen. Compared with the positive control group, the efficacy of traditional Chinese medicine high, medium, and low dose groups was low.
    CONCLUSIONS:
    Rhamnocitrin in Oxytropis Falcata can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune.
    1,5-Dicaffeoylquinic acid

    Catalog No: CFN99123
    CAS No: 30964-13-7
    Price: $238/20mg
    Salvigenin

    Catalog No: CFN99883
    CAS No: 19103-54-9
    Price: $338/10mg
    Sibiricose A5

    Catalog No: CFN90645
    CAS No: 107912-97-0
    Price: $138/20mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    alpha-Amyrin

    Catalog No: CFN92377
    CAS No: 638-95-9
    Price: $318/5mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $488/5mg