Info: More News
Science | Nature | Cell | View More
Natural Products
Tortoside A
Tortoside A
Information
CAS No. 190655-16-4 Price $368 / 5mg
Catalog No.CFN91784Purity>=98%
Molecular Weight580.58Type of CompoundLignans
FormulaC28H36O13Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison (Web)  (SDF)
Citing Use of our Products
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $423.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Anna University (India)
  • University of the Basque Country (Spain)
  • Sri Sai Aditya Institute of Pha... (India)
  • Kazusa DNA Research Institute (Japan)
  • Institute of Chinese Materia Me... (China)
  • Instituto de Investigaciones Ag... (Chile)
  • Seoul National University (Korea)
  • Hamdard University (India)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Sapienza University of Rome (Italy)
  • Subang Jaya Medical Centre (Malaysia)
  • More...
  • Package
    Featured Products
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $318/5mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $338/10mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $288/20mg
    Kaempferol-3-O-galactoside

    Catalog No: CFN92079
    CAS No: 23627-87-4
    Price: $318/10mg
    Perillen

    Catalog No: CFN90862
    CAS No: 539-52-6
    Price: $168/20mg

    Tortoside A

    Tortoside A
    Product Name Tortoside A
    CAS No.: 190655-16-4
    Catalog No.: CFN91784
    Molecular Formula: C28H36O13
    Molecular Weight: 580.58 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Source: The herbs of Ilex pubescens
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $368 / 5mg
    Download: COA    MSDS
    Similar structural: Comparison (Web)  (SDF)
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
    product package
  • TCI CO.2019, US20190151281A1
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Antioxidants (Basel).2020, 9(2):E99
  • Toxicol In Vitro.2019, 59:161-178
  • Phytochem Anal.2013, 24(5):493-503
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Oncology Letters2018, 4690-4696
  • J Food Biochem.2021, 45(7):e13774.
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • J Chromatogr Sci.2015, 53(5):824-9
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Tortoside A inhibit NFAT transcription factor.
    In vitro:
    Arch Pharm Res . 2004 Jul;27(7):738-41
    Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum[Pubmed: 15357001]
    Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), Tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 +/- 2.5 microM). However, the activities of 1 (IC50: > 500 microM) and 2 (IC50: 136.1 +/- 9.4 microM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
    Toxicol Res . 2013 Dec 31;29(4):279-83
    Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai[Pubmed: 24578798]
    Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and Tortoside A isolated from A. koreanum, was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. As a result, Tortoside A did not cause any increase in the number of his(+) revertants in S. typhimurium and E. coli WP2uvrA strains in the presence or absence of S9 mix, compared to the controls. Similarly, low concentrations of syringaresinol (750 and 1,500 μg/plate) did not show any mutagenic properties in all bacterial strains, in the presence or absence of S9 mixture. However, in the high concentration of syringaresinol (3,000 μg/plate), the number of revertants were increased in TA1535 strains, in the absence of S9 metabolic activation. Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum.
    Tortoside A Description
    Source: The herbs of Ilex pubescens
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    6-Methoxyfraxinellone

    Catalog No: CFN95485
    CAS No: N/A
    Price: $318/10mg
    Phloretin 3',5'-Di-C-glucoside

    Catalog No: CFN95306
    CAS No: 357401-40-2
    Price: $318/10mg
    Stevia impurity (13-[(2-O-6-deoxy-...

    Catalog No: CFN95229
    CAS No: 1309929-72-3
    Price: $463/5mg
    Verbasoside

    Catalog No: CFN95015
    CAS No: 61548-34-3
    Price: $318/5mg
    Clemastanin B

    Catalog No: CFN95064
    CAS No: 112747-98-5
    Price: $298/10mg
    3-Acetyl-ginsenoside F1

    Catalog No: CFN95238
    CAS No: 1881225-08-6
    Price: $318/5mg
    Cannabisin A

    Catalog No: CFN95287
    CAS No: 130508-46-2
    Price: $318/5mg
    Octyl 3-(4-hydroxyphenyl)prop-2-en...

    Catalog No: CFN95563
    CAS No: N/A
    Price: $318/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7224 mL 8.6121 mL 17.2242 mL 34.4483 mL 43.0604 mL
    5 mM 0.3445 mL 1.7224 mL 3.4448 mL 6.8897 mL 8.6121 mL
    10 mM 0.1722 mL 0.8612 mL 1.7224 mL 3.4448 mL 4.306 mL
    50 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.689 mL 0.8612 mL
    100 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Bioorg Med Chem Lett . 2016 Aug 15;26(16):3913-7.
    New naphthalene derivatives and isoquinoline alkaloids from Ancistrocladus cochinchinensis with their anti-proliferative activity on human cancer cells[Pubmed: 27423477]
    Five new compounds, named ancistronaphtosides A and B (1 and 2), anciscochine (3), anciscochine 6-O-β-d-glucopyranoside (4), and 4'-methoxy-5-epi-ancistecrorine A1 (5), together with Tortoside A (6) and 4-hydroxy-2-methoxyphenyl-6-O-syringoyl-β-d-glucopyranoside (7) were isolated from the methanolic extract of Ancistrocladus cochinchinensis. Their chemical structures were established using HR-ESI-MS, NMR spectroscopic, and chiroptical methods. Compound 5 significantly exhibited anti-proliferation against HL-60, LU-1, and SK-MEL-2 cells with IC50 values of 5.0±1.2, 6.5±1.6, and 6.8±2.0μg/mL, respectively.
    J Asian Nat Prod Res . 2006 Sep;8(6):505-10
    Studies on chemical constituents from Ilex pubescens[Pubmed: 16931425]
    Two new phenolic glycosides, ilexpubsides A and B, along with four known lignan glycosides were isolated from the roots of Ilex pubescens. By spectral evidence, the structures of the new compounds were elucidated as 4-O-beta-D-[6'-O-(4''-O-beta-D-glucopyranosylvanilloyl)glucopyranosyl] vanillic acid (1) and syringinic 6'-O-beta-D-xylopyranoside (2). The known compounds were identified to be liriodendrin (3), (-)-olivil (4), Tortoside A (5) and (+)-cyclo-olivil (6). All compounds were first isolated from Ilex pubescens.
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $318/5mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $338/10mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $288/20mg
    Kaempferol-3-O-galactoside

    Catalog No: CFN92079
    CAS No: 23627-87-4
    Price: $318/10mg
    Perillen

    Catalog No: CFN90862
    CAS No: 539-52-6
    Price: $168/20mg
    Tags: buy Tortoside A | Tortoside A supplier | purchase Tortoside A | Tortoside A cost | Tortoside A manufacturer | order Tortoside A | Tortoside A distributor