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    Natural Products
    Tovopyrifolin C
    Tovopyrifolin C
    Information
    CAS No. 34211-53-5 Price
    Catalog No.CFN96578Purity>=98%
    Molecular Weight274.23Type of CompoundXanthones
    FormulaC14H10O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Tovopyrifolin C

    Tovopyrifolin C
    Product Name Tovopyrifolin C
    CAS No.: 34211-53-5
    Catalog No.: CFN96578
    Molecular Formula: C14H10O6
    Molecular Weight: 274.23 g/mol
    Purity: >=98%
    Type of Compound: Xanthones
    Physical Desc.: Powder
    Source: The stem barks of Calophyllum venulosum.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Xanthones Compound Library
  • Biological Activity
    Description: Tovopyrifolin C is a natural product from Calophyllum venulosum.
    In vitro:
    Molecules. 2013 Feb 4;18(2):1985-94.
    Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.[Pubmed: 23381024]
    The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied.
    METHODS AND RESULTS:
    Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), Tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines.
    CONCLUSIONS:
    The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
    Tovopyrifolin C Description
    Source: The stem barks of Calophyllum venulosum.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6466 mL 18.2329 mL 36.4657 mL 72.9315 mL 91.1644 mL
    5 mM 0.7293 mL 3.6466 mL 7.2931 mL 14.5863 mL 18.2329 mL
    10 mM 0.3647 mL 1.8233 mL 3.6466 mL 7.2931 mL 9.1164 mL
    50 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.4586 mL 1.8233 mL
    100 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.7293 mL 0.9116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Asian Nat Prod Res. 2015;17(11):1104-8.
    Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum.[Pubmed: 26023810]

    METHODS AND RESULTS:
    A new pyranoxanthone, venuloxanthone (1), was isolated from the stem bark of Calophyllum venulosum, together with three other xanthones, Tovopyrifolin C (2), ananixanthone (3) and caloxanthone I (4), along with two common triterpenes, friedelin (5) and lupeol (6).
    CONCLUSIONS:
    The structures of these compounds were identified using several spectroscopic analyses which are NMR, GCMS and FTIR experiments.
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