ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $188.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Sci.2015, 16(8):18396-411Molecules.2015, 20(11):20014-30Phytomedicine.2016, 23(4):331-9HortTechnology2016, 26(6):816-819Acta horticulturae2017, 1158:257-268J Ethnopharmacol.2017, 197:157-164Evid Based Complement Alternat Me...2017...Naunyn Schmiedebergs Arch Pharmac...2017...
Phytomedicine.2018, 40:37-47Mol Cells.2018, 41(8):771-780Korean J. Crop Sci.2018, 63(2):131-139Clin Transl Oncol.2019, 10.1007Mol Microbiol.2019, 112(1):317-332Environ Toxicol.2019, 34(4):513-520.Chin J Appl. Physiol....2019...Chemistry of Natural Compounds...2019...
J Clin Med.2019, 8(10):E1664Planta Med.2019, 85(3):217-224Oxid Med Cell Longev....2020...Int J Mol Sci.2020, 21(24):9369.Molecules.2020, 25(18):4283.J of Applied Biological Chem....2020...Phytochemistry.2021, 181:112539.
Our products had been exported to the following research institutions and universities, And still growing.
University of Hertfordshire (United Kingdom)Aveiro University (Portugal)Max Rubner-Institut (MRI) (Germany)Warszawski Uniwersytet Medyczny (Poland)
Shanghai Institute of Biochemis... (China)John Innes Centre (United Kingdom)Biotech R&D Institute (USA)Universidad de Antioquia (Colombia)
Stanford University (USA)Universidade da Beira Interior (Germany)University of Auckland (New Zealand)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
University of Central Lancashire2017, 20472J Chromatogr Sci.2015, 53(5):824-9Plant Cell Tiss Org2020, 1-16Front Plant Sci.2018, 9:1424Oncology Letters2018, 4690-4696Biomed Pharmacother.2020, 125:109784.J Pharm Biomed Anal.2019, 164:119-127Asian J Beauty Cosmetol2016, 14(3):249-257Clin Exp Pharmacol Physiol.2015, 42(11):1189-97Food Chem.2018, 252:207-214
Related Screening Libraries
||Tubeimoside III has anti-inflammatory, anti-tumor, and anti-tumorigenic activities, stronger than those of tubeimoside II. It has acute toxicity, stronger than that of tubeimoside II.|
||Immunology & Inflammation related|
|Acta Pharmacol Sin. 2001 May;22(5):463-8. |
|Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor, and antitumor-promoting effects.[Pubmed: 11743898]|
|To study structure-activity relationship of tubeimosides isolated from Bolbostemma paniculatum for their anti-inflammatory, antitumor, and antitumor-promoting effects.
METHODS AND RESULTS:
Tubeimoside I, Tubeimoside II, and Tubeimoside III were isolated from tubers of Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae), a Chinese folk medicine,"Tubeimu", and their anti-inflammatory, anti-tumor, anti-tumorigenic activities, and acute toxicity were studied in vivo.
Tubeimoside I, Tubeimoside II, and Tubeimoside III are all natural analogues of oleanane type of triterpenoid saponins from the same medicinal plant, and all show anti-inflammatory, antitumor, and antitumor-promo ting effects. However, the anti-inflammatory, anti-tumor, and anti-tumorigenic activities of Tubeimoside II are stronger than those of tubeimoside I, and the acute toxicity of Tubeimoside II is lower than that of tubeimoside I; the anti-inflammatory, anti-tumor, and anti-tumorigenic activities of Tubeimoside III are stronger than those of Tubeimoside II, and the acute toxicity of Tubeimoside III is also stronger than that of Tubeimoside II.
C-16 hydroxyl group of Tubeimoside II plays an important role in enhancing biological activity of Tubeimoside II and in decreasing its toxicity. The difference of chemical structure in B and/or C position between tubeimosides III and II plays an important role in enhancing biological activity and toxicity of Tubeimoside III. Therefore tubeimosidre II may be the most promising agent for cancer chemoprevention and chemotherapy among tubeimosides I, II, and III.
|Carcinogenesis. 1995 Dec;16(12):3045-8. |
|Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum.[Pubmed: 8603483]|
METHODS AND RESULTS:
As tubeimoside I isolated from Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) has been shown to suppress tumor promoter effects, Tubeimoside III from the same plant was tested in vitro and in vivo against the action of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tubeimoside III, the natural analog of tubeimoside I, also had an anti-inflammatory effect on mouse ear edema induced by arachidonic acid and TPA and a potent anti-tumor promoting effect on two-stage carcinogenesis of mouse skin after topical application. However, the important difference in bioactivities between tubeimosides I and III is the non-activity of Tubeimoside III as an inhibitor of tumor promotion if administered orally.
Differences in metabolism connected with different routes of the compound may be one of a number of explanations of the important difference.
Tubeimoside III Description
||The bulbs of Bolbostemma paniculatum.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.