Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Vasicine
    Information
    CAS No. 6159-55-3 Price $218 / 10mg
    Catalog No.CFN97052Purity>=98%
    Molecular Weight188.2 Type of CompoundAlkaloids
    FormulaC11H12N2OPhysical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $77.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Parma (Italy)
  • Monash University (Australia)
  • Rio de Janeiro State University (Brazil)
  • University of Cincinnati (USA)
  • University of Ioannina (Greece)
  • Lodz University of Technology (Poland)
  • Macau University of Science and... (China)
  • Northeast Normal University Cha... (China)
  • Korea Intitute of Science and T... (Korea)
  • Sant Gadge Baba Amravati Univer... (India)
  • National Chung Hsing University (Taiwan)
  • More...
  • Package
    Featured Products
    Arteannuin B

    Catalog No: CFN98807
    CAS No: 50906-56-4
    Price: $228/20mg
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $100/20mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    Isolinderalactone

    Catalog No: CFN99762
    CAS No: 957-66-4
    Price: $238/10mg
    Morusinol

    Catalog No: CFN97086
    CAS No: 62949-93-3
    Price: $368/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $318/20mg

    Vasicine

    Vasicine
    Product Name Vasicine
    CAS No.: 6159-55-3
    Catalog No.: CFN97052
    Molecular Formula: C11H12N2O
    Molecular Weight: 188.2 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Targets: Antifection | AChR
    Source: The leaves of Adhatoda vasica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $218 / 10mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Anal Biochem.2019, 569:10-15
  • Postharvest Biol Tec2019, 149:18-26
  • Molecules.2020, 25(11):2599.
  • Sci Rep.2020, 10:4495(2020)
  • Phytomedicine.2019, 55:229-237
  • Molecules2021, 26(1),230
  • Arch Pharm Res.2015, 38(6):1080-9
  • American Association for Anatomy2020, doi: 10.1002.
  • J Ethnopharmacol.2017, 198:205-213
  • J Biochem Mol Toxicol.2017, 31(9)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Antioxidants Compound Library
  • Antibacterial Compound Library
  • Anticholinesterase Compound Library
  • Alkaloids Compound Library
  • Antifection Inhibitor Library
  • AChR Inhibitor Library
  • Biological Activity
    Description: Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can regulate the inflammatory reaction, have great potentials to develop safe medications for respiratory and reproductive medicine.Vasicine is also oxytocic and abortifacient agents.
    Targets: Antifection | AChR
    In vitro:
    Pak J Pharm Sci. 2012 Jul;25(3):651-6.
    Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees.[Pubmed: 22713956 ]
    Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques.
    METHODS AND RESULTS:
    Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compound (1) exhibited significant DPPH inhibition activity (70.4 ± 1.3%, IC(50) = 212.3 ± 1.9 μM). A dose dependant behavior of Vasicine (1), was indicated in the FRAP assay.
    CONCLUSIONS:
    Antibacterial activity was checked according to agar well diffusion assay and results revealed that Vasicine (1) showed moderate activity.
    Vasicine Description
    Source: The leaves of Adhatoda vasica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    3-O-Acetyl-16 alpha-hydroxytramete...

    Catalog No: CFN90804
    CAS No: 168293-13-8
    Price: $338/5mg
    Prunasin

    Catalog No: CFN97566
    CAS No: 99-18-3
    Price: $223/5mg
    Orcinol 1-O-beta-D-apiofuranosyl-(...

    Catalog No: CFN95109
    CAS No: 868557-54-4
    Price: $338/5mg
    Decuroside I

    Catalog No: CFN95004
    CAS No: 96638-79-8
    Price: $318/5mg
    Chebulinic acid

    Catalog No: CFN92296
    CAS No: 18942-26-2
    Price: $198/10mg
    Neobavaisoflavone

    Catalog No: CFN92222
    CAS No: 41060-15-5
    Price: $128/20mg
    3-Methoxyshancigusin I

    Catalog No: CFN95062
    CAS No: N/A
    Price: $413/5mg
    Stevioside D

    Catalog No: CFN95230
    CAS No: 1310055-59-4
    Price: $463/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3135 mL 26.5675 mL 53.135 mL 106.2699 mL 132.8374 mL
    5 mM 1.0627 mL 5.3135 mL 10.627 mL 21.254 mL 26.5675 mL
    10 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
    50 mM 0.1063 mL 0.5313 mL 1.0627 mL 2.1254 mL 2.6567 mL
    100 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    PLoS One. 2015 Apr 7;10(4):e0122366.
    In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor.[Pubmed: 25849329]
    Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease.
    METHODS AND RESULTS:
    This study systematically investigated the in vitro and in vivo metabolism of Vasicine in rat using ultra performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. Results indicated that renal clearance was the major excretion pathway of Vasicine. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of Vasicine and its main metabolites were also evaluated.
    CONCLUSIONS:
    The results indicated that although most metabolites maintained potential inhibitory activity against AChE and BChE, but weaker than that of Vasicine. Vasicine undergoes metabolic inactivation process in vivo in respect to cholinesterase inhibitory activity.
    Arteannuin B

    Catalog No: CFN98807
    CAS No: 50906-56-4
    Price: $228/20mg
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $100/20mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    Isolinderalactone

    Catalog No: CFN99762
    CAS No: 957-66-4
    Price: $238/10mg
    Morusinol

    Catalog No: CFN97086
    CAS No: 62949-93-3
    Price: $368/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $318/20mg