Cuscutamine | CAS:122170-93-8 | Manufacturer ChemFaces

Cuscutamine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $222.6 / In-stock
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Description:

Cuscutamine has luciferase-inducing activity and can significantly stimulate cancer cell proliferation

In vitro:

Planta Med . 2004 Apr;70(4):299-304.

Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: a stimulator of breast cancer cell proliferation[Pubmed: 15095143]

While searching for new estrogenic compounds from the plant kingdom, we investigated an extract of the seeds of Cuscuta chinensis (Convolvulaceae) which showed potency for stimulating MCF-7 cell proliferation. A novel resin glycoside, cuscutic resinoside A ( 6) was isolated along with five known compounds from the extract. The structure was deduced from its spectral data as (11 S)-hydroxyhexadecanoic acid 11- O-alpha- L-(4- O-2 R,3 R-nilylrhamnopyranosyl)-(1-->2)- O-alpha- L-rhamnopyranosyl-(1,2-lactone) forming a unique 15-membered macrocyclic lactone. The compound significantly stimulated not only MCF-7 cell proliferation but also T47D human breast cancer cells at a concentration of 10 microM. Along with Cuscutamine ( 1) and kaempferol ( 4), 6 was tested in the transient luciferase reporter assay and was found to have different luciferase inducing activity characteristics from the other compounds. These results suggest that 6 stimulated cancer cell proliferation by a different mechanism from 1 and 4.

Cuscutamine Description

Source:	The herbs of Cuscuta reflexa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

J Sep Sci . 2018 May;41(10):2169-2177.

Application of off-line two-dimensional high-performance countercurrent chromatography on the chloroform-soluble extract of Cuscuta auralis seeds[Pubmed: 29450982]

In this study, the chloroform-soluble extract of Cuscuta auralis was separated successfully using off-line two-dimensional high-performance countercurrent chromatography, yielding a γ-pyrone, two alkaloids, a flavonoid, and four lignans. The first-dimensional countercurrent separation using a methylene chloride/methanol/water (11:6:5, v/v/v) system yielded three subfractions (fractions I-III). The second-dimensional countercurrent separations, conducted on fractions I-III using n-hexane/ethyl acetate/methanol/water/acetic acid (5:5:5:5:0, 3:7:3:7:0, and 1:9:1:9:0.01, v/v/v/v/v) systems, gave maltol (1), (-)-(13S)-Cuscutamine (2), (+)-(13R)-Cuscutamine (3), (+)-pinoresinol (4), (+)-epipinoresinol (5), kaempferol (6), piperitol (7), and (9R)-hydroxy-d-sesamin (8). To the best of our knowledge, maltol was identified for the first time in Cuscuta species. Furthermore, this report details the first full assignment of spectroscopic data of two Cuscutamine epimers, (-)-(13S)-Cuscutamine and (+)-(13R)-Cuscutamine.

CAS No.	122170-93-8	Price	$318 / 5mg
Catalog No.	CFN95323	Purity	> 95%
Molecular Weight	270.3	Type of Compound	Alkaloids
Formula	C₁₅H₁₄N₂O₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Cuscutamine
CAS No.:	122170-93-8
Catalog No.:	CFN95323
Molecular Formula:	C₁₅H₁₄N₂O₃
Molecular Weight:	270.3 g/mol
Purity:	> 95%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cuscuta reflexa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$318 / 5mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6996 mL	18.498 mL	36.9959 mL	73.9919 mL	92.4898 mL
5 mM	0.7399 mL	3.6996 mL	7.3992 mL	14.7984 mL	18.498 mL
10 mM	0.37 mL	1.8498 mL	3.6996 mL	7.3992 mL	9.249 mL
50 mM	0.074 mL	0.37 mL	0.7399 mL	1.4798 mL	1.8498 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.7399 mL	0.9249 mL

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CFN92785	1,2,3,4-Tetrahydronorharman-1-one	17952-82-8	186.2	C₁₁H₁₀N₂O
CFN95323	Cuscutamine	122170-93-8	270.3	C₁₅H₁₄N₂O₃
CFN96036	1-Methoxyindole-3-carboxylic acid	91913-76-7	191.2	C₁₀H₉NO₃
CFN96052	Caulilexin C	30536-48-2	186.2	C₁₁H₁₀N₂O
CFN91557	N-Methylserotonin	1134-01-6	190.2	C₁₁H₁₄N₂O
CFN98111	Gramine	87-52-5	174.25	C₁₁H₁₄N₂
CFN91165	Bufotenine	487-93-4	204.3	C₁₂H₁₆N₂O
CFN91166	Cinobufotenine	60657-23-0	219.3	C₁₃H₁₉N₂O
CFN90037	Melatonin	73-31-4	232.28	C₁₃H₁₆N₂O₂