YM155 (Sepantronium Bromide) | CAS:781661-94-7

YM155 (Sepantronium Bromide)

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Scoparone

Catalog No: CFN99314
CAS No: 120-08-1
Price: $30/20mg

Chebulagic acid

Catalog No: CFN92295
CAS No: 23094-71-5
Price: $ / mg

Ferruginol

Catalog No: CFN92178
CAS No: 514-62-5
Price: $ / mg

Eupatorin

Catalog No: CFN97418
CAS No: 855-96-9
Price: $158/10mg

Gambogenic acid

Catalog No: CFN92097
CAS No: 173932-75-7
Price: $218/20mg

Asperglaucide

Catalog No: CFN98937
CAS No: 56121-42-7
Price: $238/5mg

Cyanidin-3-O-sambubioside chloride

Catalog No: CFN92173
CAS No: 33012-73-6
Price: $643/10mg

Flavokawain C

Catalog No: CFN90741
CAS No: 56798-34-6
Price: $238/10mg

Cardamonin

Catalog No: CFN99890
CAS No: 19309-14-9
Price: $40/20mg

Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg

Description:

YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells.

Targets:

XIAP | Autophagy

In vitro:

Clin Cancer Res,2008 Oct 15;14(20):6496-504.

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines.[Pubmed: 18927289]

Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effect of YM155, a small-molecule inhibitor of survivin expression, on the sensitivity of human non-small cell lung cancer (NSCLC) cell lines to gamma-radiation.
METHODS AND RESULTS:
The radiosensitizing effect of YM155 was evaluated on the basis of cell death, clonogenic survival, and progression of tumor xenografts. Radiation-induced DNA damage was evaluated on the basis of histone H2AX phosphorylation and foci formation.YM155 induced down-regulation of survivin expression in NSCLC cells in a concentration- and time-dependent manner. A clonogenic survival assay revealed that YM155 increased the sensitivity of NSCLC cells to gamma-radiation in vitro. The combination of YM155 and gamma-radiation induced synergistic increases both in the number of apoptotic cells and in the activity of caspase-3. Immunofluorescence analysis of histone gamma-H2AX also showed that YM155 delayed the repair of radiation-induced double-strand breaks in nuclear DNA. Finally, combination therapy with YM155 and gamma-radiation delayed the growth of NSCLC tumor xenografts in nude mice to a greater extent than did either treatment modality alone.
CONCLUSIONS:
These results suggest that YM155 sensitizes NSCLC cells to radiation both in vitro and in vivo, and that this effect of YM155 is likely attributable, at least in part, to the inhibition of DNA repair and enhancement of apoptosis that result from the down-regulation of survivin expression. Combined treatment with YM155 and radiation warrants investigation in clinical trials as a potential anticancer strategy.

YM155 (Sepantronium Bromide) Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	YM155 (Sepantronium Bromide)
Price:
CAS No.:	781661-94-7
Catalog No.:	CFN60046
Molecular Formula:	C₂₀H₁₉BrN₄O₃
Molecular Weight:	443.29 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Autophagy Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2559 mL	11.2793 mL	22.5586 mL	45.1172 mL	56.3965 mL
5 mM	0.4512 mL	2.2559 mL	4.5117 mL	9.0234 mL	11.2793 mL
10 mM	0.2256 mL	1.1279 mL	2.2559 mL	4.5117 mL	5.6396 mL
50 mM	0.0451 mL	0.2256 mL	0.4512 mL	0.9023 mL	1.1279 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	0.4512 mL	0.564 mL

CFN96542	Sutchuenmedin A	1197194-31-2	658.65	C₃₃H₃₈O₁₄
CFN92436	Isothymonin	99615-01-7	360.3	C₁₈H₁₆O₈
CFN99855	Taxinine B	18457-44-8	664.8	C₃₇H₄₄O₁₁
CFN92105	Wilfortrine	37239-48-8	873.8	C₄₁H₄₇NO₂₀