Science | Nature | Cell | View More
Natural Products
Yunnancoronarin A
Yunnancoronarin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Yunnancoronarin A
Price:
CAS No.: 162762-93-8
Catalog No.: CFN99689
Molecular Formula: C20H28O2
Molecular Weight: 300.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Hedychium yunnanense
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Auburn University (USA)
  • Imperial College London (United Kingdom)
  • National Cancer Center Research... (Japan)
  • Massachusetts General Hospital (USA)
  • Johannes Gutenberg University M... (Germany)
  • Universidad de Antioquia (Colombia)
  • University of Madras (India)
  • Technical University of Denmark (Denmark)
  • Universitas islam negeri Jakarta (Indonesia)
  • Shanghai University of TCM (China)
  • University of Leipzig (Germany)
  • More...
Package
Featured Products
Vicenin -3

Catalog No: CFN92032
CAS No: 59914-91-9
Price: $198/20mg
Roemerine

Catalog No: CFN91019
CAS No: 548-08-3
Price: $318/5mg
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Senkyunolide A

Catalog No: CFN99594
CAS No: 62006-39-7
Price: $90/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Angelicide

Catalog No: CFN93012
CAS No: 92935-94-9
Price: $ / mg
Falcarinol

Catalog No: CFN96027
CAS No: 21852-80-2
Price: $218/20mg
Pinoresinol

Catalog No: CFN98775
CAS No: 487-36-5
Price: $188/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
In vitro:
Phytother Res. 2010 Jul;24(7):1009-13.
Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells.[Pubmed: 19960422]

METHODS AND RESULTS:
Seven labdane-type diterpenes, coronarin E, coronarin A, Yunnancoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC(50) of 0.40 microM, which was higher than that of the drug ellipticine (IC(50) 1.79 microM). Moreover, ellipticine was very toxic to Vero cells (IC(50) 7.47 microM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 microM.
CONCLUSIONS:
The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development.
Yunnancoronarin A Description
Source: The herbs of Hedychium yunnanense
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Chamigrenol

Catalog No: CFN95247
CAS No: 19822-80-1
Price: $318/10mg
(3beta,22alpha)-26-(beta-glucopyra...

Catalog No: CFN95321
CAS No: 107783-53-9
Price: $318/20mg
Isochlorogenic acid C 4'-O-glucosi...

Catalog No: CFN95405
CAS No: N/A
Price: $413/5mg
cis-Aegineoside

Catalog No: CFN95295
CAS No: N/A
Price: $413/5mg
3-Hydroxymollugin

Catalog No: CFN95424
CAS No: 154706-45-3
Price: $368/5mg
Complanatoside C

Catalog No: CFN95144
CAS No: N/A
Price: $318/5mg
Apigenin 6,8-di-C-alpha-L-arabinop...

Catalog No: CFN95360
CAS No: 73140-47-3
Price: $318/10mg
10-O-trans-p-Feruloylscandoside

Catalog No: CFN95392
CAS No: 1428268-72-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Chem Pharm Bull (Tokyo). 2008 Feb;56(2):210-2.
Cytotoxicity of labdane-type diterpenoids from Hedychium forrestii.[Pubmed: 18239312]
Two new labdane-type diterpenoids, hedyforrestin D (1) and 15-ethoxy-hedyforrestin D (2), and three known compounds, Yunnancoronarin A (4), B (3) and C (5) were isolated from the rhizomes of Hedychium forrestii.
METHODS AND RESULTS:
The structure of the new diterpenoids was established as 6beta,15xi-dihydroxylabda-8(17),11,13-trien-15,16-olide (1), and 6beta-hydroxy-15xi-ethoxylabda-8(17),11,13-trien-15,16-olide (2) on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562 through 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays. Of these, compounds 3 and 4 exhibited the most activity with IC(50) values of 0.92 and 2.20 microM, respectively, whereas 5 was inactive against A549 cells and 1 was inactive against both cell lines up to a concentration of 300.81 microM.
CONCLUSIONS:
This shows that both the hydroxy substitution and orientation of unsaturated lactone group in the five-membered ring of C-13 to C-16 seem to play an important role in the anti-tumor activities of human lung adenocarcinoma and leukemia.
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2009 Jan;34(2):180-2.
[Studies on chemical constituents from rhizomes of Hedychium chrysoleucum].[Pubmed: 19385181]
To investigate the chemical constituents from the rhizome o fHedychium chrysoleucum.
METHODS AND RESULTS:
The compounds were isolated by column chromatography on silica gel. The structures were identified by NMR, IR and MS analyses. Seven compounds were isolated and identified as hedychenone (1), coronarin A (2), Yunnancoronarin A (3), coronarin E (4), beta-sitosterol (5), cryptomeridiol (6), and beta-eudesmol (7).
CONCLUSIONS:
Compounds 1-7 were obtained from this plant for the first time.
Vicenin -3

Catalog No: CFN92032
CAS No: 59914-91-9
Price: $198/20mg
Roemerine

Catalog No: CFN91019
CAS No: 548-08-3
Price: $318/5mg
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Senkyunolide A

Catalog No: CFN99594
CAS No: 62006-39-7
Price: $90/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Angelicide

Catalog No: CFN93012
CAS No: 92935-94-9
Price: $ / mg
Falcarinol

Catalog No: CFN96027
CAS No: 21852-80-2
Price: $218/20mg
Pinoresinol

Catalog No: CFN98775
CAS No: 487-36-5
Price: $188/20mg
Tags: buy Yunnancoronarin A | Yunnancoronarin A supplier | purchase Yunnancoronarin A | Yunnancoronarin A cost | Yunnancoronarin A manufacturer | order Yunnancoronarin A | Yunnancoronarin A distributor