ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Biosci Biotechnol Biochem....2021...Molecules.2019, 24(24),4583Chemistry of Plant Materials....2016...Int J Mol Sci.2021, 22(19):10220.Applied Physics B2021, 127(92).Antioxidants (Basel).2021, 10(9):1487.J Nat Med.2017, 71(2):457-462Enzyme and Microbial Technology...2022...
The Journal of Phytopharmacology...2020...J Mol Med (Berl).2018, 96(7):661-672Plant J.2017, 90(3):535-546Front Pharmacol.2019, 10:1226Biomed Pharmacother.2021, 139:111585. Molecules. 2013, 18(7):7376-88Plants (Basel).2021, 10(11):2317. Antioxidants (Basel).2020, 9(2): E119
Saudi Pharm J2020, 10.1016Sci Rep.2021, 11(1):10931.Chemistry of Plant Materials....2019...Anal Chim Acta.2021, 1180:338874.Sci Rep.2015, 5:13194Int J Mol Sci.2017, 19(1)J Exp Bot.2016, 67(12):3777-88
More...
Our products had been exported to the following research institutions and universities, And still growing.
Complutense University of Madrid (Spain)University of Perugia (Italy)Periyar University (India)Cornell University (USA)
University of Canterbury (New Zealand)Anna University (India)Kyung Hee University (Korea)University of Cincinnati (USA)
John Innes Centre (United Kingdom)Sri Ramachandra University (India)University of Bonn (Germany)
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Zeylasterone
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Faculty of Chem. & Nat. Resource Eng.2014, 62Fitoterapia.2022, 105141.Food Addit Contam Part A.2021, 38(12):1985-1994.Wageningen University & Research2018, January 2018Phytother Res.2019, 33(7):1784-1793Cytotechnology.2017, 69(5):765-773Institute of Food Science & Technology2021, 56(11).Korean J Dent Mater2020, 47(2):63-70.Asian Pac J Cancer Prev.2019, 20(1):65-72Int Immunopharmacol.2019, 71:361-371
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Triterpenoids Compound Library |
| Description: |
Zeylasterone shows bactericidal activity. |
| In vitro: |
| Microbiol Res. 2010 Oct 20;165(8):617-26. | | Antibacterial properties of zeylasterone, a triterpenoid isolated from Maytenus blepharodes, against Staphylococcus aureus.[Pubmed: 20116223 ] | The anti-staphylococcal properties of Zeylasterone and demethylZeylasterone, two 6-oxophenolic triterpenoids isolated from Maytenus blepharodes, were investigated.
METHODS AND RESULTS:
Zeylasterone was more active than demethylZeylasterone on Staphylococcus aureus cells, showing bactericidal activity at 30 μg/ml (6 × MIC) in less than three hours and bacteriostatic at lower concentrations. At the same cell density, a more drastic reduction in CFU count was obtained when the triterpenoid was incorporated into cultures growing actively. Zeylasterone at 3 × MIC added on S. aureus cultures showed an early inhibitory effect on incorporation of radiolabeled thymidine, uridina and N-acetyl-glucosamine, and later on leucine. It also caused cell membrane disruption in S. aureus, as shown by the inhibition of radiolabeled precursor uptake, rapid potassium leakage, inhibition of NADH oxidation, and formation of mesosome-like structures around the septa.
CONCLUSIONS:
The structural features of the molecule, the blockage of solute transport through the membrane and changes in its permeability, suggest that Zeylasterone acts mainly on cytoplasmic membrane. | | J Appl Microbiol. 2008 May;104(5):1266-74. | | Activity and mechanism of the action of zeylasterone against Bacillus subtilis.[Pubmed: 18070038] | To investigate the antimicrobial properties of 6-oxophenolic triterpenoids isolated from Maytenus blepharodes against different micro-organisms and the mode of action on Bacillus subtilis.
METHODS AND RESULTS:
The activity of Zeylasterone and demethylZeylasterone was evaluated by microdilution method. Zeylasterone showed a higher activity, being active against Gram-positive bacteria (minimum inhibitory concentration 3-20 microg ml(-1)) and Candida albicans (10 microg ml(-1)). Killing curves revealed a bacteriostatic effect on B. subtilis that was dependent on the growth phase and inoculum size. Zeylasterone caused cell membrane alterations in B. subtilis, as shown by potassium leakage and formation of mesosome-like structures. However, membrane disruption was not revealed by either LIVE/DEAD Baclight assay or measurement of intracellular constituent efflux. Zeylasterone showed an early effect on N-acetyl-glucosamine and uridine incorporation and later on that of thymidine and leucine.
CONCLUSIONS:
Diverse micro-organisms exhibit sensitivities towards compounds studied. The permeability changes in the cytoplasmic membrane and nonsimultaneous ceasing of macromolecular synthesis suggest that Zeylasterone could act on multiple targets on B. subtilis. The activity showed against B. subtilis as a model of spore-forming bacteria would provide valuable information for further studies in the development of 6-oxophenolic triterpenoids as antiseptic and disinfectant properties. |
|
Zeylasterone Description
| Source: |
The herbs of Tripterygium wilfordii |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9584 mL |
9.792 mL |
19.584 mL |
39.1681 mL |
48.9601 mL |
| 5 mM |
0.3917 mL |
1.9584 mL |
3.9168 mL |
7.8336 mL |
9.792 mL |
| 10 mM |
0.1958 mL |
0.9792 mL |
1.9584 mL |
3.9168 mL |
4.896 mL |
| 50 mM |
0.0392 mL |
0.1958 mL |
0.3917 mL |
0.7834 mL |
0.9792 mL |
| 100 mM |
0.0196 mL |
0.0979 mL |
0.1958 mL |
0.3917 mL |
0.4896 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
