Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    trans-Methylisoeugenol
    Information
    CAS No. 6379-72-2 Price
    Catalog No.CFN96259Purity>=98%
    Molecular Weight178.2Type of CompoundPhenylpropanoids
    FormulaC11H14O2Physical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Lodz (Poland)
  • Universidade Católica Portuguesa (Portugal)
  • Uniwersytet Gdański (Poland)
  • Shanghai Institute of Organic C... (China)
  • University of Illinois at Chicago (USA)
  • The University of Newcastle (Australia)
  • Charles Sturt University (Denmark)
  • Georgia Institute of Technology (USA)
  • University of Liège (Belgium)
  • Tohoku University (Japan)
  • Universiti Sains Malaysia (Malaysia)
  • More...
  • Package
    Featured Products
    Zederone

    Catalog No: CFN92616
    CAS No: 7727-79-9
    Price: $278/20mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Oroselol

    Catalog No: CFN95001
    CAS No: 1891-25-4
    Price: $358/5mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    Ginsenoside Rg6

    Catalog No: CFN90565
    CAS No: 147419-93-0
    Price: $318/5mg
    Neochamaejasmine B

    Catalog No: CFN92152
    CAS No: 90411-12-4
    Price: $418/5mg
    Isofebrifugine

    Catalog No: CFN92303
    CAS No: 32434-44-9
    Price: $488/20mg

    trans-Methylisoeugenol

    trans-Methylisoeugenol
    Product Name trans-Methylisoeugenol
    CAS No.: 6379-72-2
    Catalog No.: CFN96259
    Molecular Formula: C11H14O2
    Molecular Weight: 178.2 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Oil
    Targets: 5-HT Receptor
    Source: The roots of Atractylodes macrocephala
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Molecules.2020, 25(3):734
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Front Plant Sci.2020,11:630.
  • Oncotarget.2015, 6(31):30831-49
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Free Radic Biol Med.2017, 112:191-199
  • Industrial Crops and Products2017, 95:286-295
  • Dent Mater J.2020, 39(4):690-695
  • Sci Adv.2018, 4(10)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Antibacterial Compound Library
  • Antifungal Compound Library
  • Food additives Compound Library
  • Antidepressant Compound Library
  • Anxiolytic Compound Library
  • Phenylpropanoids Compound Library
  • 5-HT Receptor Inhibitor Library
  • Biological Activity
    Description: (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) can cause moderate reversible inhibition of glutathione S-transferases (GSTs)(I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).The use of isoeugenol methyl ether(trans-Methylisoeugenol) is described as an agent to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or to combat bad breath.
    Targets: 5-HT Receptor
    In vivo:
    PAT-WO2006032664
    Use of isoeugenol methyl ester as an agent against bad breath[Reference: WebLink]

    METHODS AND RESULTS:
    The use of isoeugenol methyl ether(trans-Methylisoeugenol)is described as an agent (i) to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or (ii) to combat bad breath.
    Food Funct. 2014 Aug;5(8):1819-28.
    Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.[Pubmed: 24920211 ]
    (E)-methyl isoeugenol (MIE, trans-Methylisoeugenol) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive.
    METHODS AND RESULTS:
    Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. MIE at 250 and 500 mg kg(-1) potentiated the hypnotic effect of sodium pentobarbital. However, MIE did not protect against PTZ-induced convulsion. Except for MIE at 500 mg kg(-1), parameters evaluated in the LDB, EPM and OF demonstrated an anxiolytic like property of MIE. This effect was blocked by WAY100635 pretreatment. MIE at 500 mg kg(-1) elicited a reduction in locomotor activity of the mice in the OF. Anti-immobility effect of MIE 250 mg kg(-1) in the FST suggested an antidepressive like property. Unlike AMPT, pretreatment with PCPA reversed the antidepressant like effect of MIE.
    CONCLUSIONS:
    Our findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways.
    trans-Methylisoeugenol Description
    Source: The roots of Atractylodes macrocephala
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    1-Methoxycarbonyl-beta-carboline-N...

    Catalog No: CFN95023
    CAS No: 74690-74-7
    Price: $318/5mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $/mg
    Rosmarinyl glucoside

    Catalog No: CFN95297
    CAS No: 910028-78-3
    Price: $413/5mg
    3-Oxo-4-benzyl-3,4-dihydro-1H-pyrr...

    Catalog No: CFN95293
    CAS No: 60026-28-0
    Price: $413/5mg
    Quasipanaxatriol

    Catalog No: CFN95248
    CAS No: 171903-78-9
    Price: $413/5mg
    Afzelin

    Catalog No: CFN98757
    CAS No: 482-39-3
    Price: $288/20mg
    Cannabiscitrin

    Catalog No: CFN95278
    CAS No: 520-14-9
    Price: $318/5mg
    Kobophenol A

    Catalog No: CFN92530
    CAS No: 124027-58-3
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6117 mL 28.0584 mL 56.1167 mL 112.2334 mL 140.2918 mL
    5 mM 1.1223 mL 5.6117 mL 11.2233 mL 22.4467 mL 28.0584 mL
    10 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    50 mM 0.1122 mL 0.5612 mL 1.1223 mL 2.2447 mL 2.8058 mL
    100 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Chem Biol Interact. 1996 Jan 5;99(1-3):85-97.
    Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products.[Pubmed: 8620581]

    METHODS AND RESULTS:
    The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man. The reversible inhibition of human and rat GST by eugenol, eugenol methyl ether, isoeugenol methyl ether(trans-Methylisoeugenol), 2-allylphenol and 4-propylphenol was also studied using purified isoenzymes. The reversible inhibition of human and rat GSTs, using 1-chloro-2,4-dinitrobenzene as substrate, was expressed as I25. All compounds caused moderate reversible inhibition (I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).
    CONCLUSIONS:
    In rat, eugenol methyl ether was the strongest inhibitor. In human, the overall inhibiting capacities of eugenol, eugenol methyl ether, isoeugenol methyl ether (trans-Methylisoeugenol) and 4-propyl phenol were more or less similar; 2-allylphenol was the poorest inhibitor.
    Zederone

    Catalog No: CFN92616
    CAS No: 7727-79-9
    Price: $278/20mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Oroselol

    Catalog No: CFN95001
    CAS No: 1891-25-4
    Price: $358/5mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    Ginsenoside Rg6

    Catalog No: CFN90565
    CAS No: 147419-93-0
    Price: $318/5mg
    Neochamaejasmine B

    Catalog No: CFN92152
    CAS No: 90411-12-4
    Price: $418/5mg
    Isofebrifugine

    Catalog No: CFN92303
    CAS No: 32434-44-9
    Price: $488/20mg