ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules. 2013, 18(11):14105-21PLoS One.2015, 10(5):e0127060Acta Pharm Sin B.2015, 5(4):323-9.Mediators Inflamm.2016, 2016:7216912Kor. J. Pharmacogn.2016, 47(1):62-72J.Acta Agriculturae Scandinavica...2017...Korean J. of Horticultural Sci. &...2017...Int J Mol Sci.2018, 19(9):E2528
Cell Biochem Funct.2018, 36(6):303-311Korean Journal of Pharmacognosy...2018...Chemistry of Natural Compounds...2018...Wageningen University & Research...2018...Toxins (Basel).2019, 11(10):E575J of Essential Oil Research...2019...Int J Mol Sci.2019, 20(3):E651Molecules.2019, 24(11):E2102
Molecules.2019, 24(19):E3417Journal of Oil Palm Research...2019...Food and Chemical Toxicology...2020...Agronomy2020, 10(3),388.Molecules.2020, 25(20):4851.Eur Endod J.2020, 5(1):23-27.J Agric Food Chem....2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Lodz (Poland)Universidade Católica Portuguesa (Portugal)Uniwersytet Gdański (Poland)Shanghai Institute of Organic C... (China)
University of Illinois at Chicago (USA)The University of Newcastle (Australia)Charles Sturt University (Denmark)Georgia Institute of Technology (USA)
University of Liège (Belgium)Tohoku University (Japan)Universiti Sains Malaysia (Malaysia)
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Molecules.2020, 25(3):734J of Pharmaceutical Analysis2020, doi: 10.1016Front Plant Sci.2020，11:630.Oncotarget.2015, 6(31):30831-49Research J. Pharm. and Tech.2020, 13(7):3059-3064.J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025Free Radic Biol Med.2017, 112:191-199Industrial Crops and Products2017, 95:286-295Dent Mater J.2020, 39(4):690-695Sci Adv.2018, 4(10)
Related Screening Libraries
(E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) can cause moderate reversible inhibition of glutathione S-transferases (GSTs)(I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).The use of isoeugenol methyl ether(trans-Methylisoeugenol) is described as an agent to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or to combat bad breath.|
|Use of isoeugenol methyl ester as an agent against bad breath[Reference: WebLink]|
METHODS AND RESULTS:
The use of isoeugenol methyl ether(trans-Methylisoeugenol)is described as an agent (i) to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or (ii) to combat bad breath.
|Food Funct. 2014 Aug;5(8):1819-28. |
|Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.[Pubmed: 24920211 ]|
|(E)-methyl isoeugenol (MIE, trans-Methylisoeugenol) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive.
METHODS AND RESULTS:
Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. MIE at 250 and 500 mg kg(-1) potentiated the hypnotic effect of sodium pentobarbital. However, MIE did not protect against PTZ-induced convulsion. Except for MIE at 500 mg kg(-1), parameters evaluated in the LDB, EPM and OF demonstrated an anxiolytic like property of MIE. This effect was blocked by WAY100635 pretreatment. MIE at 500 mg kg(-1) elicited a reduction in locomotor activity of the mice in the OF. Anti-immobility effect of MIE 250 mg kg(-1) in the FST suggested an antidepressive like property. Unlike AMPT, pretreatment with PCPA reversed the antidepressant like effect of MIE.
Our findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways.
||The roots of Atractylodes macrocephala
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chem Biol Interact. 1996 Jan 5;99(1-3):85-97. |
|Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products.[Pubmed: 8620581]|
METHODS AND RESULTS:
The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man.
The reversible inhibition of human and rat GST by eugenol, eugenol methyl ether, isoeugenol methyl ether(trans-Methylisoeugenol), 2-allylphenol and 4-propylphenol was also studied using purified isoenzymes. The reversible inhibition of human and rat GSTs, using 1-chloro-2,4-dinitrobenzene as substrate, was expressed as I25. All compounds caused moderate reversible inhibition (I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).
In rat, eugenol methyl ether was the strongest inhibitor. In human, the overall inhibiting capacities of eugenol, eugenol methyl ether, isoeugenol methyl ether (trans-Methylisoeugenol) and 4-propyl phenol were more or less similar; 2-allylphenol was the poorest inhibitor.