1. Rubiadin has hepatoprotective effects against carbon tetrachloride (CCl 4 )-induced hepatic damage in rats.
2. Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
3. Rubiadin can decrease bone loss through the inhibition of osteoclast formation,differentiation and bone resorption.
4. Rubiadin exhibits strong antitumor promoting activity at the concentration of 2.0 μg/ml when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells.
1. Diosgenin enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression.
2. Diosgenin exhibits inhibitory effects on superoxide anion production through the blockade of cAMP, PKA, cPLA2, PAK, Akt and MAPKs signaling pathways, this may explain the clinical implications of Diosgenin in the treatment of inflammation-related disorders.
3. Diosgenin has enough potential to improve the coronary function and interfere the osteochondrogenic transdifferentiation program of aortic VSMC which supports its antivascular calcification potential.
4. Diosgenin suppresses proliferation, inhibits invasion, and suppresses osteoclastogenesis through inhibition of NF-kappaB-regulated gene expression and enhances apoptosis induced by cytokines and chemotherapeutic agents.
5. Diosgenin and L-deprenyl can increase vulnerability of ApoE4 neurons to HIV proteins and opiates, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia, thus they may have therapeutic potential in this population.
1. (-)-Gallocatechin gallate can precipitate cholesterol.
2. (-)-Gallocatechin gallate decreasees osteoclastogenesis at 20 microM.
3. (-)-Gallocatechin gallate inhibits production and extracellular release of maltose binding protein and a periplasmic protein into the culture supernatant.
|CFN99815||Ganoderic acid DM
1. Ganoderic acid DM (GADM), with 5α-reductase inhibitory and androgen receptor (AR) binding activity, can inhibit prostate cancer cell growth and block osteoclastogenesis.
2. GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells.
1. Sarsasapogenin has anti-inflammatory effect.
2. Sarsasapogenin exhibited antitumor activity, by cytotoxicity, inducing apoptosis, reactive oxygen species (ROS)-mediate mitochondrial dysfunction and ER stress cell death.