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    2,3,23-Trihydroxy-12-oleanen-28-oic acid
    2,3,23-Trihydroxy-12-oleanen-28-oic acid
    Information
    CAS No. 102519-34-6 Price
    Catalog No.CFN99041Purity>=98%
    Molecular Weight488.7 Type of CompoundTriterpenoids
    FormulaC30H48O5Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Related Libraries
  • Cytotoxic Compound Library
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  • Biological Activity
    Description: 2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.
    In vitro:
    Lishizhen Medicine & Materia Medica Research, 2008,19(8):1931-2.
    Triterpenes from Glochidion coccineum and their Cytotoxicity in Vitro[Reference: WebLink]
    To study the chemical constituents of Glochidion coccineum and their cytotoxicity in vitro.
    METHODS AND RESULTS:
    Various column chromatographic technologies were applied for isolation and purification and the structures were elucidated by spectral evidence.MTT method was applied to investigate their cytotoxic activities. Six compounds were isolated from the part of ethyl acetate and identified as Glochidiol ①,Lup-20(29)-ene-1α,23-diol ②,Glochidone ③,Epi-lupeol ④,3β,19α,23α-trihydroxy-12-oleanen-28-oic acid ⑤,2β,3β,23α-trihydroxy-12-oleanen-28-oic acid(2,3,23-Trihydroxy-12-oleanen-28-oic acid ) ⑥.
    CONCLUSIONS:
    The above compounds were obtained from this plant for the first time;compounds 1~4 showed cytotoxic activities to human hepatoma(BEL-7402),as well as compounds 5 and 6 to lung adenocarcinoma(A-549)cell lines.
    Molecules. 2015 Oct 22;20(10):19252-62.
    Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells.[Pubmed: 26506336 ]
    Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects.
    METHODS AND RESULTS:
    In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts. According to their structural characteristics, these compounds were divided into dammarane-type, oleanane- and ursane-type. Dammarane-type triterpenoids were isolated for the first time from the Juglans genus. As part of our continuing search for biologically active compounds from this plant, all of these compounds were also evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by the MTT assay.
    CONCLUSIONS:
    The results were shown that 20(S)-protopanaxadiol, 2α,3β,23-trihydroxyolean-12-en-28-oic acid (2,3,23-Trihydroxy-12-oleanen-28-oic acid ) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibited better cytotoxicity in vitro with IC50 values of 10.32±1.13, 16.13±3.83, 15.97±2.47 μM, respectively. Preliminary structure-activity relationships for these compounds were discussed.
    2,3,23-Trihydroxy-12-oleanen-28-oic acid Description
    Source: The leaves and roots of Camptotheca acuminata Decaisne
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.