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    2',3'-Dehydrosalannol
    Information
    CAS No. 97411-50-2 Price
    Catalog No.CFN97589Purity>=98%
    Molecular Weight554.68Type of CompoundTriterpenoids
    FormulaC32H42O8Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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  • Biological Activity
    Description: 2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells.
    Targets: Bcl-2/Bax | Caspase | Akt
    In vitro:
    Anticancer Res. 2012 Jul;32(7):2801-6.
    The anticancer effect of 2'-3'-dehydrosalannol on triple-negative breast cancer cells.[Pubmed: 22753740]
    Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast tumors and these breast tumors are usually aggressive and highly metastatic. Unfortunately, treatment options for TNBCs are limited; we have identified a novel molecule,2',3'-Dehydrosalannol (DHS) and in this study we investigated the anticancer effect of DHS against TNBC cells.
    METHODS AND RESULTS:
    TNBC (MDA-MB 231; MDA-MB 468) cells were treated with DHS and its effect on cell viability, apoptosis and molecular mechanisms were analyzed. DHS inhibited growth and induced apoptosis in TNBC cell lines. Molecular analysis suggested that DHS inhibited cathepsin-mediated pro-survival signaling [pAKT: phosphorylated protein kinase B; BCL-2: B-cell lymphoma 2 and cyclin D1] and induced pro-apoptotic markers such as BAX [BCL-2-associated X protein] and cleaved caspase-3.
    CONCLUSIONS:
    Our results demonstrate that DHS inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells. These findings suggest that DHS may be a promising agent for the prevention and treatment of TNBC.
    2',3'-Dehydrosalannol Description
    Source: The barks of Azadirachta indica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8028 mL 9.0142 mL 18.0284 mL 36.0568 mL 45.071 mL
    5 mM 0.3606 mL 1.8028 mL 3.6057 mL 7.2114 mL 9.0142 mL
    10 mM 0.1803 mL 0.9014 mL 1.8028 mL 3.6057 mL 4.5071 mL
    50 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.7211 mL 0.9014 mL
    100 mM 0.018 mL 0.0901 mL 0.1803 mL 0.3606 mL 0.4507 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Acta Crystallogr C. 2002 Nov;58(Pt 11):o681-2.
    2',3'-Dehydrosalannol.[Pubmed: 12415181]

    METHODS AND RESULTS:
    2',3'-Dehydrosalannol, methyl (2aS,3R,5R,5aS,6S,6aS,8R,9aS,10aR,10bR,10cS)-8-(3-furyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-3-hydroxy-2a,5a,6a,7-tetramethyl-5-(3-methylbut-2-enoyloxy)-2H,3H-cyclopenta[4',5']furo[2',3':6,5]benzo[cd]isobenzofuran-6-acetate, C(32)H(42)O(8), was isolated from uncrushed green leaves of Azadirachta indica A. Juss (neem) and has been found to possess antifeedant activity against Spodptera litura.
    CONCLUSIONS:
    The conformations of the functional groups are similar to those of 3-desacetylsalannin, which was isolated from neem kernels. The molecules are linked into chains by intermolecular O-H.O hydrogen bonds.