ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Phytomedicine15 Dec. 2015,1262–1268Yakugaku Zasshi.2018 Jan 30;Sci Rep. Jan. 2018Plant Cell, (PCTOC)05 November 2016Plant Cell Physiol.2018 Jan 1;
Molecules. 2016 Oct 20Sci Rep. 2017 Jan 9;The Korea Society of Pharmacognosy.2014Biol Pharm Bull.2017;40(6)Cell Physiol Biochem.2017;43(4):1425-1435.
Phytomedicine1 March 2018;J. of Food Composition & Analysis2017Tumour Biol.2015 Jun 26BMC Pharmacol Toxicol. 2018 Jan 31;
Our products had been exported to the following research institutions and universities, And still growing.
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University of Queensland (Australia)Technical University of Denmark (Denmark)Auburn University (USA)Max Rubner-Institut (MRI) (Germany)
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||Centaureidin augments IFN-gamma promoter activity by approximately four-fold. Centaureidin shows potential vasorelaxant activity. It inhibits dendrite outgrowth from melanocytes by activating Rho, resulting in the inhibition of melanosome transfer from melanocytes to keratinocytes.|
||Potassium Channel | IFN-γ|
|Biochim Biophys Acta. 2006 Mar;1760(3):487-94. |
|Centaureidin promotes dendrite retraction of melanocytes by activating Rho.[Pubmed: 16476521]|
METHODS AND RESULTS:
Centaureidin induces significant morphological changes in normal human epidermal melanocytes and inhibits melanocyte dendrite elongation, resulting in a reduction of melanosome transfer in an in vitro melanocyte-keratinocyte co-culture system. We studied the effects of Centaureidin on the small GTPases. In in vitro binding assay, Centaureidin activated Rho and furthermore, a Rho inhibitor (C. botulinum C3 exoenzyme), a Rho kinase inhibitor (Y27632) and a small GTPase inhibitor (Toxin B) blocked dendrite retraction induced by Centaureidin.
These results suggest Centaureidin could act via the Rho signaling pathway, and it may directly or indirectly activate Rho. Thus, Centaureidin appears to inhibit dendrite outgrowth from melanocytes by activating Rho, resulting in the inhibition of melanosome transfer from melanocytes to keratinocytes.
|Planta Med. 1998 Mar;64(2):116-9. |
|Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis.[Pubmed: 9580164]|
METHODS AND RESULTS:
In this work, the potential vasorelaxant activity of centaurein and Centaureidin, two flavonoids from Centaurea corcubionensis, were studied for the first time in rat aorta. Centaureidin (10 microM-0.1 mM) totally relaxed, in a concentration-dependent manner and with almost equal effectiveness, the contractions induced by NA (IC50 = 16.7 +/- 1.9 microM) or by a high K+ concentration (IC50 = 16.1 +/- 3.1 microM) in intact rat aortic rings. Mechanical removal of endothelium did not significantly modify the vasoralexant effects of this flavone (IC50 = 20.8 +/- 2.4 microM for NA; IC50 = 21 +/- 2.9 microM for K+). On the other hand, centaurein (1 microM-0.1 mM) had no effect on NA- and high K(+)-induced contractions in rubbed and intact rat aortic rings.
These results indicate that substitution by glucose in the chemical structure of Centaureidin leads to the loss of its vasodilator activity.
|J Ethnopharmacol. 2007 Jun 13;112(2):232-6. |
|Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression.[Pubmed: 17408892]|
METHODS AND RESULTS:
Centaurein (EC(50)=75 microg/ml) and its aglycone, Centaureidin (EC(50)=0.9 microg/ml), isolated from this butanol subfraction, augmented IFN-gamma promoter activity by approximately four-fold.
||The herbs of Eupatorium fortunei Turcz.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.