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    Centaureidin
    Information
    CAS No. 17313-52-9 Price
    Catalog No.CFN90433Purity>=98%
    Molecular Weight360.31Type of CompoundFlavonoids
    FormulaC18H16O8Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Centaureidin augments IFN-gamma promoter activity by approximately four-fold.
    2. Centaureidin inhibits dendrite outgrowth from melanocytes by activating Rho, resulting in the inhibition of melanosome transfer from melanocytes to keratinocytes.
    3. Centaureidin shows potential vasorelaxant activity.
    Targets: Potassium Channel | IFN-γ
    Centaureidin Description
    Source: The herbs of Eupatorium fortunei Turcz.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7754 mL 13.8769 mL 27.7539 mL 55.5078 mL 69.3847 mL
    5 mM 0.5551 mL 2.7754 mL 5.5508 mL 11.1016 mL 13.8769 mL
    10 mM 0.2775 mL 1.3877 mL 2.7754 mL 5.5508 mL 6.9385 mL
    50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.5551 mL 0.6938 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Centaureidin References Information
    Citation [1]

    Biochim Biophys Acta. 2006 Mar;1760(3):487-94.

    Centaureidin promotes dendrite retraction of melanocytes by activating Rho.[Pubmed: 16476521]
    Centaureidin induces significant morphological changes in normal human epidermal melanocytes and inhibits melanocyte dendrite elongation, resulting in a reduction of melanosome transfer in an in vitro melanocyte-keratinocyte co-culture system. We studied the effects of Centaureidin on the small GTPases. In in vitro binding assay, Centaureidin activated Rho and furthermore, a Rho inhibitor (C. botulinum C3 exoenzyme), a Rho kinase inhibitor (Y27632) and a small GTPase inhibitor (Toxin B) blocked dendrite retraction induced by Centaureidin. These results suggest Centaureidin could act via the Rho signaling pathway, and it may directly or indirectly activate Rho. Thus, Centaureidin appears to inhibit dendrite outgrowth from melanocytes by activating Rho, resulting in the inhibition of melanosome transfer from melanocytes to keratinocytes.
    Citation [2]

    Planta Med. 1998 Mar;64(2):116-9.

    Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis.[Pubmed: 9580164]
    In this work, the potential vasorelaxant activity of centaurein and Centaureidin, two flavonoids from Centaurea corcubionensis, were studied for the first time in rat aorta. Centaureidin (10 microM-0.1 mM) totally relaxed, in a concentration-dependent manner and with almost equal effectiveness, the contractions induced by NA (IC50 = 16.7 +/- 1.9 microM) or by a high K+ concentration (IC50 = 16.1 +/- 3.1 microM) in intact rat aortic rings. Mechanical removal of endothelium did not significantly modify the vasoralexant effects of this flavone (IC50 = 20.8 +/- 2.4 microM for NA; IC50 = 21 +/- 2.9 microM for K+). On the other hand, centaurein (1 microM-0.1 mM) had no effect on NA- and high K(+)-induced contractions in rubbed and intact rat aortic rings. These results indicate that substitution by glucose in the chemical structure of Centaureidin leads to the loss of its vasodilator activity.
    Citation [3]

    J Ethnopharmacol. 2007 Jun 13;112(2):232-6.

    Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression.[Pubmed: 17408892]
    Centaurein (EC(50)=75 microg/ml) and its aglycone, Centaureidin (EC(50)=0.9 microg/ml), isolated from this butanol subfraction, augmented IFN-gamma promoter activity by approximately four-fold.