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    Chlojaponilactone B
    Chlojaponilactone B
    Information
    CAS No. 1449382-91-5 Price
    Catalog No.CFN89106Purity>=98%
    Molecular Weight286.32Type of CompoundSesquiterpenoids
    FormulaC17H18O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.
    Targets: NO | NOS | TNF-α | IL Receptor | p65 | NF-kB | IkB | IKK
    In vitro:
    J Nat Prod. 2016 Sep 23;79(9):2257-63.
    Chlojaponilactone B from Chloranthus japonicus: Suppression of Inflammatory Responses via Inhibition of the NF-κB Signaling Pathway.[Pubmed: 27588583 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of an ethanolic extract of Chloranthus japonicus led to the isolation of the known lindenane-type sesquiterpenoid Chlojaponilactone B (1). This compound exhibited pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Further anti-inflammatory assays showed that 1 suppressed the levels of some key inflammation mediators, such as iNOS, TNF-α, and IL-6, in a dose-dependent manner, and reduced the ear thickness and neutrophil infiltration in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated mice.
    CONCLUSIONS:
    A mechanistic study revealed that compound 1 exerted its anti-inflammatory effects via the suppression of the NF-κB signaling pathway, which inhibited NF-κB-dependent transcriptional activity, IκBα phosphorylation, and p65 nuclear translocation. In contrast, Chlojaponilactone B (1) was found to exert little influence on the MAPK signaling pathway.
    Chlojaponilactone B Description
    Source: The whole plants of Chloranthus japonicus.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4926 mL 17.463 mL 34.926 mL 69.8519 mL 87.3149 mL
    5 mM 0.6985 mL 3.4926 mL 6.9852 mL 13.9704 mL 17.463 mL
    10 mM 0.3493 mL 1.7463 mL 3.4926 mL 6.9852 mL 8.7315 mL
    50 mM 0.0699 mL 0.3493 mL 0.6985 mL 1.397 mL 1.7463 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6985 mL 0.8731 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Helvetica Chimica Acta, 2013, 96(7):1386-1391.
    Chlojaponilactones B – E, Four New Lindenane Sesquiterpenoid Lactones from Chloranthus japonicus[Reference: WebLink]

    METHODS AND RESULTS:
    Reinvestigation of the AcOEt-soluble part of the EtOH extract of whole plants of Chloranthus japonicus afforded four new lindenane-type sesquiterpenoid lactones, Chlojaponilactone B,chlojaponilactone C, chlojaponilactone D, chlojaponilactone E (1–4, resp.), together with nine known sesquiterpenoids.
    CONCLUSIONS:
    Their structures and relative configurations were established on the basis of extensive spectroscopic data and by comparison with the relevant literature.