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    Chlorophorin
    Chlorophorin
    Information
    CAS No. 537-41-7 Price
    Catalog No.CFN92323Purity>=98%
    Molecular Weight380.5Type of CompoundPhenols
    FormulaC24H28O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
    Targets: Tyrosinase | Antifection
    In vitro:
    Planta Med 2014; 80 - P2O73
    The inhibitory effect of chemical constituents derived from Artocarpus xanthocarpus on melanin biosynthesis[Reference: WebLink]

    METHODS AND RESULTS:
    Eighteen known compounds and six new compounds were isolated from the roots of Artocarpus xanthocarpus, and their structures were spectroscopically determined. The new compounds included artoxanthocarpuone A (1), artoxanthocarpuone B (2), hydroxylakoochin A (3), methoxylakoochin A (4), epoxylakoochin A (5), and artoxanthol (6). Among the isolated compounds, artoxanthol (6), arboctalol (9) steppogenin (11), norartocarpetin (12), resveratrol (19), oxyresveratrol (20), and Chlorophorin (21) strongly inhibited mushroom tyrosinase activity with IC50 values of 5.7 ± 0.3, 6.4 ± 0.3, 1.9 ± 0.1, 0.9 ± 0.1, 4.9 ± 0.3, 1.0 ± 0.5, and 2.5 ± 0.4μM, respectively.
    CONCLUSIONS:
    Artoxanthocarpuone A (1), artoxanthocarpuone B (2), methoxylakoochin A (4), lakoochin A (8), cudraflavone C (17), artonin A (18), resveratrol (19), and Chlorophorin (21) reduced tyrosinase activity and inhibited α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells and were not cytotoxic. Collectively, our results suggest the potential utility of A. xanthocarpus-derived compounds as depigmenting agents.
    J Ethnopharmacol. 2001 Nov;78(1):59-66.
    Anti-amoebic activity of plant compounds from Virgilia oroboides and Chlorophora excelsa.[Pubmed: 11585689]
    The anti-amoebic activity of four plant extracts: maackiain and formononetin from Virgilia oroboides and Chlorophorin and Iroko from Chlorophora excelsa, were evaluated.
    METHODS AND RESULTS:
    Anti-protozoal tests conducted on trophozoites of Entamoeba histolytica established that all four compounds had an affect on the trophozoites to some degree. Chlorophorin showed the highest anti-protozoal activity with an MIC of 0.25 microg/ml followed by maackiain and Iroko with MICs of 1 microg/ml. Chlorophorin and Iroko induced the release of acid phosphatase. Chlorophorin reduced alpha amylase levels by 89%. Formononetin and maackiain had a minimal effect on the enzyme levels. Ultrastructural changes occurred in trophozoites treated with plant compounds. The degree of destruction of the trophozoites increased with an increase in compound concentration. Trophozoite destruction was initiated by the disintegration of the nucleus and culminated with the rupture of the cytoplasmic membrane.
    CONCLUSIONS:
    Maackiain was the only compound that showed some level of mutagenicity. Formononetin and Iroko were very slightly mutagenic, while Chlorophorin was non-mutagenic. In addition, none of the compounds tested showed cytopathic effects on any of the cell lines tested. Chlorophorin and Iroko exhibit the potential to be exploited as natural multi-functional safe control agents in the treatment of bacterial, fungal and protozoal infections.
    Chlorophorin Description
    Source: The herbs of Chlorophora excelsa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6281 mL 13.1406 mL 26.2812 mL 52.5624 mL 65.703 mL
    5 mM 0.5256 mL 2.6281 mL 5.2562 mL 10.5125 mL 13.1406 mL
    10 mM 0.2628 mL 1.3141 mL 2.6281 mL 5.2562 mL 6.5703 mL
    50 mM 0.0526 mL 0.2628 mL 0.5256 mL 1.0512 mL 1.3141 mL
    100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.5256 mL 0.657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Planta Med. 1998 Jun;64(5):408-12.
    The inhibitory components from Artocarpus incisus on melanin biosynthesis.[Pubmed: 9690341 ]
    The inhibitory effects of methanol extracts of heartwood of 23 Papua New Guinean wood species on tyrosinase activity were examined.
    METHODS AND RESULTS:
    The extract of Artocarpus incisus showed the strongest tyrosinase inhibitory activity which was equivalent to kojic acid. The extract apparently inhibited melanin biosynthesis of both cultured B16 melanoma cells without any cytotoxicity and in the back of a brown guinea pig without skin irritation. Thus, the potentiality of the extracts of heartwood of A. incisus both as material of a useful skin whitening agent and as a remedy for disturbances in pigmentation is evident.
    CONCLUSIONS:
    Tyrosinase inhibitory activity-guided fractionation led to the isolation of seven active compounds including a new compound which has been characterized as 6-(3"-methyl-1"-butenyl)-5,7,2',4'-tetrahydroxyflavone, named isoartocarpesin. Other active compounds were (+)-dihydromorin, Chlorophorin, (+)-norartocarpanone, 4-prenyloxyresveratrol, artocarbene, and artocarpesin, These compounds are probably responsible for the melanin biosynthesis inhibitory effects.