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    Chrysothol
    Information
    CAS No. 911714-91-5 Price
    Catalog No.CFN97477Purity>=98%
    Molecular Weight238.4 Type of CompoundSesquiterpenoids
    FormulaC15H26O2Physical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: Chrysothol shows strong antimicrobial activities (MICs=50-100 ug/ml) against enterobacteria E. coli and S. enteritidis. It also shows anti-cancer activity against human breast cancer cells.
    Targets: Antifection
    In vitro:
    Pancreatology, 2006 ,6 (3) :175-9.
    Belgian Pancreatic Club Session at the 18th Belgian Week of Gastroenterology[Reference: WebLink]

    METHODS AND RESULTS:
    Fractions from the petroleum extracts showed strong antimicrobial activity, against Escherichia coli ATCC 25922, E. coli -LM 1 , E. coli -LM 2 , and Salmonella enteritidis -MI, with MICs values between 31.2 and 125μg/ml. The bioassay-guided fractionation of the petroleum ether extracts led to the isolation of nine terpenes: azorellolide ( 1 ), mulinol ( 2 ), stachytriol ( 3 ),1α,10β,4β,5α-diepoxy-7β-germacran-6β-ol ( 4 ), 1β,10α,4β,5α-diepoxy-7β-germacran-6β-ol ( 5 ), 1,2,3,3α,4,5,6,7,8,8α-decahydro-7-(1-hydroxy-1-methylethyl)-1,4-dimethylazulene-3α,8α-diol ( 6 ), madreporanone ( 7 ), yaretol ( 8 ) and chrysotol or 6β,10β-epoxy-4α-hydroxyguaiane ( 9 ). Compounds 3 , 5 , 6 and 9 are reported here for the first time from A. cryptantha . Their structures and relative configurations have been determinated by means 1D and 2D NMR techniques.
    CONCLUSIONS:
    Chrysothol ( 9 ), madreporanone ( 7 ), and stachytriol ( 3 ) showed strong antimicrobial activities (MICs=50–100μg/ml) against enterobacteria E. coli and S. enteritidis . The antibacterial activity found for some of the isolated compounds supports least in part, the commercial exploited of this species to treat food-borne illnesses associated with Gram negative pathogenic bacteria.
    Chrysothol Description
    Source: The rhizomes of Acorus calamus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1946 mL 20.9732 mL 41.9463 mL 83.8926 mL 104.8658 mL
    5 mM 0.8389 mL 4.1946 mL 8.3893 mL 16.7785 mL 20.9732 mL
    10 mM 0.4195 mL 2.0973 mL 4.1946 mL 8.3893 mL 10.4866 mL
    50 mM 0.0839 mL 0.4195 mL 0.8389 mL 1.6779 mL 2.0973 mL
    100 mM 0.0419 mL 0.2097 mL 0.4195 mL 0.8389 mL 1.0487 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochemistry. 2006 Jul;67(14):1547-53.
    Constituents of Chrysothamnus viscidiflorus.[Pubmed: 16808933]

    METHODS AND RESULTS:
    A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [Chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported.
    CONCLUSIONS:
    Compounds Chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells.