ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
International Journal of Pharmacognosy.2015 7(1).Biofactors.2017 Oct 24.Journal of Pharmaceutical Analysis2016 May 5; Kor. J. Pharmacogn.47(1):62-72(2016)Industrial Crops and ProductsFeb. 2018;
Experimental Parasitology2015 March 24.Molecules. 2017 Feb 21;Molecules. 2017 Mar 7;Research on Crops.2017, Issue : 3Horticultural Science2016
Korean Herb. Med. Inf. 2016;4(1):35-42J Basic Clin Physiol Pharmacol.2015 Aug 15FEMS Microbiol Lett. 2017 Jun 15;Phytochem Anal.2016 Sep;
Our products had been exported to the following research institutions and universities, And still growing.
Medical University of Gdansk (Poland)Shanghai University of TCM (China)National Cancer Institute (USA)Nicolaus Copernicus Uniwersity (Poland)
S.N.D.T. Women's University (India)Instytut Nawozów Sztucznych w P... (Poland)Wroclaw Medical University (Poland)The University of Newcastle (Australia)
Institute of Bioorganic Chemistr... (Poland)Chang Gung University (Taiwan)Fraunhofer-Institut für Molekul... (Germany)
|| Cyclo(L-Phe-trans-4-hydroxy-L-Pro) is a natural product from Phellinus igniarius.|
|Fisheries & Aquatic Science, 2015 , 18 (1) :35-44. |
|Evaluation on Anticancer Effect Against HL-60 Cells and Toxicity in vitro and in vivo of the Phenethyl Acetate Isolated from a Marine Bacterium Streptomyces griseus[Reference: WebLink]|
|We previously identified Streptomyces griseus as an anti-cancer agent (Kim et al., 2014). In this study, we isolated compounds from S. griseus and evaluated their anticancer effect and toxicity in vitro and in vivo.
METHODS AND RESULTS:
Preparative centrifugal partition chromatography (CPC) was used to obtain three compounds, cyclo(L-[4-hydroxyprolinyl]- L –leucine], Cyclo(L-Phe-trans-4-hydroxy-L-Pro) and phenethyl acetate (PA). We chose PA, which had the highest anticancer activity, as a target compound for further experiments. PA induced the formation of apoptotic bodies, DNA fragmentation, DNA accumulation in G0/G1 phase, and reactive oxygen species (ROS) formation. Furthermore, PA treatment increased Bax/Bcl-xL expression, activated caspase-3, and cleaved poly-ADP-ribose polymerase (PARP) in HL-60 cells. Simultaneous evaluation in vitro and in vivo, revealed that PA exhibited no toxicity in Vero cells and zebrafish embryos.
We revealed, for the first time, that PA generates ROS, and that this ROS accumulation induced the Bcl signaling pathway.
||From Phellinus igniarius
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Nat Prod Res. 2014;28(5):318-23. |
|A new cyclic tetrapeptide from an endophytic Streptomyces sp. YIM67005.[Pubmed: 24304298]|
|One new cyclic tetrapeptide, cyclo(L-Tyr-L-Pro-L-Phe-trans-4-hydroxy-L-Pro) (1), together with two known cyclodipeptides, Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (2) and cyclo(L-Val-L-Tyr) (3), were isolated from the fermentation broth of Streptomyces sp. YIM67005 associated with Inula cappa DC.
METHODS AND RESULTS:
The planar structure of compound 1 was determined on the basis of spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by the application of the advanced Marfey method. The cytotoxicity and antimicrobial activity of compound 1 were investigated.