ChemFaces is a professional high-purity natural products manufacturer.
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More articles cited ChemFaces products.
Molecules. 2018 Jan 24;J Sep Sci. 2017 Dec 27.Free Radic Biol Med.2016 Jun 25;97:307-319. Integr Med Res.2017 Dec;Phytomedicine. 2017 Jan 15;
Sci Rep. 2017 Dec 11;Phytomedicine2015 August 14Mol Med Rep.2015 Sep 21JPCMarch 16, 2017Tea Res. Ins. Of ChinaJuly 13, 2017;
J Nat Med.2017 Apr;Molecules.2017 Oct 27;Preprints.25 Dec. 2017;J Ethnopharmacol. 2016 Jul 12.
Our products had been exported to the following research institutions and universities, And still growing.
National Hellenic Research Found... (Greece)Sant Gadge Baba Amravati Univers... (India)Universita' Degli Studi Di Cagli... (Italy)Chinese University of Hong Kong (China)
Chulalongkorn University (Thailand)University of Ioannina (Greece)Indian Institute of Science (India)Tohoku University (Japan)
University of Hertfordshire (United Kingdom)University of Maryland School of... (USA)University of Madras (India)
||Cyclo(Phe-Val) is a new cell cycle inhibitor, it shows cyctoxic activity in vitro.|
|Journal of Shenyang Pharmaceutical University, 2007, 24(8):474-8. |
|Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum[Reference: WebLink]|
|To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.|
METHODS AND RESULTS:
Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis.MTT assay was used to evaluate the bioactivities in vitro.Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),Cyclo(Phe-Val)(3),cyclo-(Ile-Leu)(3),cyclo-(Val-Val)(4),cyclo-(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,3 and 5 show cytotoxic activity in vitro.
|Journal of Shenyang Pharmaceutical University, 2015 (2):107 -10. |
|Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522[Reference: WebLink]|
|To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.|
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),cyclo(Ala-Ile)(2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and Cyclo(Phe-Val)(6).
Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
||From Penicillium oxalicum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Evidence-Based Complementary and Alternative Medicine Volume 2011 (2011), Article ID 393752, 6 pages |
|Description of a Sulfitobacter Strain and Its Extracellular Cyclodipeptides[Reference: WebLink]|
|A marine bacterium M44 was separated from 30 m deep seawater in the East China Sea (26° 28.3′ N 122° 29.0′ E) in 2006. 16S rDNA gene sequence comparison showed that the strain M44 was a member of the genus Sulfitobacter and highly similar to KMM 3554T. A series of experiments demonstrated that this strain M44 had many distinctive characteristics: its cells were gram-negative and mesophilic; its colonies were slightly yellowish, round, convex, and smooth; and it could grow at 10–28°C, pH 6.0–10.0, and in the presence of 0–12.5% (w/v) NaCl; the optimum growth conditions were 25°C and pH 7.0, and the optimum Na+ concentration was 2.5%. In addition, strain M44 contained 18 : 1 ω7c, 11 methyl 18 : 1 ω7c and 16 : 0 fatty acids as major fatty acids, and the genomic DNA G+C content was 58.04 mol%. |
METHODS AND RESULTS:
According to our results of the secondary metabolites, six cyclodipeptides were isolated from the strain M44, which were Cyclo (Val-Leu), Cyclo(Phe-Val), Cyclo (Phe-Leu), Cyclo (Leu-Ile), Cyclo (Phe-Ile), and Cyclo (Trp-Pro).
It is the first study of secondary metabolites isolated from this genus.