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    D-Glucosamine hydrochloride
    D-Glucosamine hydrochloride
    Information
    CAS No. 66-84-2 Price $30 / 20mg
    Catalog No.CFN99194Purity>=98%
    Molecular Weight215.63Type of CompoundMiscellaneous
    FormulaC6H13NO5.HClPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: D-glucosamine hydrochloride has antimicrobial effect on the common 21 strains of food spoilage microorganisms, it could as preservative agent was used to preserve nature eleo juice. D-glucosamine hydrochloride also has antitumor, antiinflammaty, and anti-arthritis effects, it induces cell apoptosis by blocking of cell-cycle.
    Targets: TGF-β/Smad | TNF-α | COX | NOS | IL Receptor | Calcium Channel
    In vitro:
    Chinese Journal of Marine Drugs, 2008, 27(6):20-5.
    Effects of D-glucosamine hydrochloride on the cell-cycle and expression of proteins in gastric carcinoma cell SGC-7901[Reference: WebLink]
    To study the effects of D-Glucosamine hydrochloride on the apoptosis of gastric carcinoma cell line SGC-7901 and its mechanism.
    METHODS AND RESULTS:
    SRB assay was used to examine the effects of D-Glucosamine hydrochloride on the growth inhibition of SGC-7901.The cell-cycle and expression of cytochrome-C were observed by flow cytometry,the concentrations of intracellular Ca2+ was determined by CLSM and the expressions of cyclinB1,calcinerin were investigated by Western-Blot. D-Glucosamine hydrochloride could block SGC-7901 cell-cycle at S phase of cell division,increase the concentration of intracellular Ca2+ and decrease the expression of cyclinB1,the expressions of calcinerin and cytochrome-c were increased respectively.
    CONCLUSIONS:
    Block of cell-cycle may be one of the mechanism of inducing cell apoptosis by D-Glucosamine hydrochloride.
    Fisheries Science, 2001, 18(2):14-5.
    Studies on Antimicrobial Effects of D-glucosamine Hydrochloride.[Reference: WebLink]
    The antimicrobial effect of D-Glucosamine hydrochloride(GAH)was investigated.
    METHODS AND RESULTS:
    It was found that GAH had antimicrobial effects on the common 21 strains of food spoilage microorganisms.The minimal inhibition concentration is 0 5 g/L,for mould is 2 g/L,for yeast is 1 g/L.In addition,it showed better preservation effect while GAH as preservative agent was used to preserve nature eleo juice.
    In vivo:
    Mar Drugs. 2012 Aug;10(8):1873-82.
    Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.[Pubmed: 23015778 ]

    METHODS AND RESULTS:
    D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration.
    CONCLUSIONS:
    These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
    Phytother Res. 2014 Jul;28(7):1054-63
    Effect of fucoxanthin alone and in combination with D-glucosamine hydrochloride on carrageenan/kaolin-induced experimental arthritis in rats.[Pubmed: 24338843]
    The objective of the present study was to investigate the effect of the fucoxanthin (FUCO) alone and in combination with glucosamine hydrochloride (GAH) on carrageenan/kaolin-induced inflammatory arthritis model in rats and to explore its underlying mechanisms.
    METHODS AND RESULTS:
    Joint swelling, muscle weight ratio (%), histopathological examination and scoring, and proteoglycan degradation were examined. Pro-inflammatory interleukin (IL-1β) and tumor necrosis (TNF-α) levels, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase(iNOS) protein expression and nitric oxide (NO) level in knee synovial tissue extract were analyzed using enzyme-linked immunosorbent assay, western blotting analysis, and Griess reagent assay, respectively. FUCO and FUCO + GAH not only may significantly reduce degrees of knee joint swelling and prevent against muscle atrophy, but also may significantly attenuate inflammation in synovial tissue, cartilage erosion, and proteoglycan loss. The efficacies of FUCO + GAH were stronger than that of GAH or FUCO. FUCO alone and FUCO + GAH can significantly inhibit upregulation of COX-2 and iNOS protein expressions, decrease of IL-1β and TNF-α levels, and reduce NO production in knee synovial tissue extract.
    CONCLUSIONS:
    These results indicated that FUCO is an effective anti-arthritis agent through an antiinflammation mechanism. FUCO may enhance therapeutic effect of GAH on rat arthritis through mechanism of antiinflammation.
    D-Glucosamine hydrochloride Description
    Source: Present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6376 mL 23.1879 mL 46.3757 mL 92.7515 mL 115.9393 mL
    5 mM 0.9275 mL 4.6376 mL 9.2751 mL 18.5503 mL 23.1879 mL
    10 mM 0.4638 mL 2.3188 mL 4.6376 mL 9.2751 mL 11.5939 mL
    50 mM 0.0928 mL 0.4638 mL 0.9275 mL 1.855 mL 2.3188 mL
    100 mM 0.0464 mL 0.2319 mL 0.4638 mL 0.9275 mL 1.1594 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Chinese Journal of Natural Medicines, 2003, 1(4):237-9.
    Antitumor Effect of D-Glucosamine Hydrochloride in Mice[Reference: WebLink]
    To study the antit umor effect of D-Glucosamine·HCl(D-GlcN·HCl) in tumor-bearing mice by ig route.
    METHODS AND RESULTS:
    Weight of tumor,peripheral leckocyte count,WBC /RBC ratio of marr ow cell an d body weight were used as index which was observed to evaluate the antitumor ef fect of D- GlcN·HCl. The results showed that tumor inhibitory r ate of D-Glucosamine hydrochloride (20,10 mg/kg) on S 180 reached 66 .7% and 57.1% respectively. It could obviously prolong the survival days of mice with Heps. Surviva l p rolong rate of Heps-bearing mice reached 208.2% and 133.7% respectively by i g D-Glucosamine hydrochloride (20,10 mg/kg). It also had good inhibitory action of on the tumor wei ght of the mice with EC and had no inhibitory effect on peripheral leukocyte,WB C/RBC ratio of bone marrow and weights of tumor-bearing mice.
    CONCLUSIONS:
    This study showed that the inhibitory effect of D-Glucosamine hydrochloride on S 180 ,Heps and EC in mice was remarkable, and it had no obvious inhib itory a ction on peripheral leukocyte,WBC/RBC ratio of bone marrow and weights of tumor -bearing mice.