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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $18.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...J. of Agricultural Science...2015...Sci Rep.2015, 5:13194Molecules.2016, 21(6)Food and Bioprocess Technology...2017...Invest New Drugs.2017, 35(2):166-179Korean J. of Horticultural Sci. &...2017...RSC Advances2017, 86
Evid Based Complement Alternat Me...2018...Academic J of Second Military Med...2018...Eur J Pharmacol.2018, 832:96-103Nat Commun.2019, 10(1):5169J Chromatogr B Analyt Technol Bio...2019...J of Physics Conference Series...2019...BMC Complement Altern Med....2019...Life Sci.2019, 216:259-270
Molecules.2019, 24(11):E2044Molecules.2019, 24(2):E343Molecules.2019, 24(20):3755Molecules.2019, 24(22):E4022Chemistry of Natural Compounds...2019...Food Funct.2020, 10.1039Biochem Biophys Res Commun....2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Hertfordshire (United Kingdom)Imperial College London (United Kingdom)Warszawski Uniwersytet Medyczny (Poland)Tokyo Woman's Christian University (Japan)
University of Vigo (Spain)Universidade da Beira Interior (Germany)Cancer Research Initatives Foun... (Malaysia)Heidelberg University (Germany)
Universidad de Buenos Aires (Argentina)Universidad de La Salle (Mexico)Sanford Burnham Medical Researc... (USA)
Related Screening Libraries
||D-Pinitol is a safe nutrient to reduce calorie consumption when supplementing with creatine. It exerts anti-inflammatory, insulin-like activities; and inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells, which in turn protect bone loss from ovariectomy. It inhibits the activation of p38, JNK, and NF-κB, the expression of p53, Bcl-2, Bax and NF-kB proteins, and reduces focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity.|
||GLUT | Src | NF-kB | FAK | p53 | Bcl-2/Bax|
|Int J Mol Sci. 2013 May 8;14(5):9790-802. |
|D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways.[Pubmed: 23698767]|
|Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-Pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been proven to induce tumor apoptosis and metastasis of cancer cells.
METHODS AND RESULTS:
In this study, we investigated the anti-metastasis effects of D-Pinitol in human prostate cancer cells. We found that D-Pinitol reduced the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. Treatment of prostate cancer cells with D-Pinitol reduced mRNA and cell surface expression of αvβ3 integrin. In addition, D-Pinitol exerted its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-kB activation.
Thus, D-Pinitol may be a novel anti-metastasis agent for the treatment of prostate cancer metastasis.
|Int Immunopharmacol. 2012 Mar;12(3):494-500. |
|D-pinitol inhibits RANKL-induced osteoclastogenesis.[Pubmed: 22269833]|
|Numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. D-Pinitol, a 3-methoxy analogue of D-chiroinositol, was identified as an active principle in soy foods and legumes.
METHODS AND RESULTS:
Here we found that D-Pinitol markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from bone marrow stromal cells and RAW264.7 macrophage cells. In addition, D-Pinitol also reduced RANKL-induced p38 and JNK phosphorylation. Furthermore, RANKL-mediated increase of IKK, IκBα, and p65 phosphorylation and NF-κB-luciferase activity was inhibited by D-Pinitol. However, D-Pinitol did not affect the proliferation and differentiation of osteoblasts. In addition, D-Pinitol also prevented the bone loss induced by ovariectomy in vivo.
Our data suggest that D-Pinitol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated RANKL-induced p38, JNK, and NF-κB activation, which in turn protect bone loss from ovariectomy.
||The barks of Acacia nilotica
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Asian Pac J Cancer Prev. 2014;15(4):1757-62. |
|D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB.[Pubmed: 24641404]|
|Development of drugs from natural products has been undergoing a gradual evoluation. Many plant derived compounds have excellent therapeutic potential against various human ailments. They are important sources especially for anticancer agents. A number of promising new agents are in clinical development based on their selective molecular targets in the field of oncology.
METHODS AND RESULTS:
D-Pinitol is a naturally occurring compound derived from soy which has significant pharmacological activitites. Therefore we selected D-Pinitol in order to evaluate apoptotic potential in the MCF-7 cell line. Human breast cancer cells were treated with different concentrations of D-Pinitol and cytotoxicity was measured by MTT and LDH assays. The mechanism of apoptosis was studied with reference to expression of p53, Bcl-2, Bax and NF-kB proteins. The results revealed that D-Pinitol significantly inhibited the proliferation of MCF-7 cells in a concentration-dependent manner, while upregulating the expression of p53, Bax and down regulating Bcl-2 and NF-kB.
Thus the results obtained in this study clearly vindicated that D-Pinitol induces apotosis in MCF-7 cells through regulation of proteins of pro- and anti-apoptotic cascades.