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|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Korean Journal of Pharmacognosy...2014...China Pharmacy2015, 26(27)Br J Pharmacol.2016, 173(2):396-410Phytochemistry Letters2017, 449-455Sci Rep.2017, 7:40345Nutrients.2018, 10(7)Nat Chem Biol.2018, 14(8):760-763Integr Cancer Ther.2018, 17(3):832-843
Industrial Crops and Products...2018...Sci Adv.2018, 4(10)Phytomedicine.2018, 40:37-47Primary and Industrial.2018, 52(11)Front Cell Infect Microbiol.2018, 8:292Journal of Life Science2018, 917-922Clin Transl Oncol.2019, 10.1007World J Mens Health.2019, 10.5534
Front Pharmacol.2019, 10:1355J Ethnopharmacol.2019, 244:112074J of the Korean Society of Food S...2019...Environ Toxicol.2019, 34(4):513-520.J Funct Foods2019, 54:449-456Planta Med.2019, 85(9-10):766-773LWT-Food Sci Technol2020, 109163
Our products had been exported to the following research institutions and universities, And still growing.
Heinrich-Heine-University Düss... (Germany)Lund University (Sweden)Sanford Burnham Medical Researc... (USA)Wageningen University (Netherlands)
Siksha O Anusandhan University (India)University of Queensland (Australia)Regional Crop Research Institute (Korea)National Hellenic Research Foun... (Greece)
Nicolaus Copernicus Uniwersity (Poland)Chiang Mai University (Thailand)Seoul National University (Korea)
Related Screening Libraries
||Dehydroevodiamine hydrochloride has novel anti-cholinesterase and antiamnesic activities, it inhibits acetylcholinesterase activity in a dose-dependent and non-competitive manner(IC50=37.8 microM); its potent antiamnesic effect is thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement. Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv) can increase the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats, suggest that it selectively increases cerebral blood flow.|
|J Nat Prod. 1994 Mar;57(3):387-9. |
|Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa.[Pubmed: 8201313]|
METHODS AND RESULTS:
Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined.
These results suggest that the compound selectively increases cerebral blood flow.
Dehydroevodiamine hydrochloride Description
||The leaves of Evodia rutaecarpa.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 1996 Oct;62(5):405-9. |
|Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa.[Pubmed: 8923803 ]|
To find a new compound with antiamnesic activity, we screened 29 natural products for their abilities to inhibit acetylcholinesterase and reverse scopolamine-induced amnesia.
METHODS AND RESULTS:
Among the plants tested Evodia rutaecarpa Bentham showed a strong inhibitory effect on acetylcholinesterase in vitro and an anti-amnesic effect in vivo. By sequential fractionation of E. rutaecarpa, the active component was finally identified as Dehydroevodiamine hydrochloride (DHED). DHED inhibited acetylcholinesterase activity in a dose-dependent and non-competitive manner. The IC50 value of DHED is 37.8 microM. A single administration of DHED to rats (6.25 mg/kg) significantly reversed the scopolamine-induced memory impairment in a passive avoidance test. The antiamnesic effect of DHED was more potent than that of tacrine which is the only drug for Alzheimer's disease approved by FDA. This potent antiamnesic effect of DHED was thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement.
These results indicate that DHED has novel anti-cholinesterase and antiamnesic activities and might have therapeutic potential in various disorders including Alzheimer's disease.