ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Universidade Estadual Paulista2017-02-19Sci Rep. 2016; 6: 25094.2016 Apr 27;6:25094. Korean J. of Food Sci. and TechApril 2016Br J Pharmacol.2016 Jan;173(2):396-410.Tropical J. of Pha. ResearchNo 3 (2017)
Invest New Drugs. 2017 Apr;Biochem Systematics and EcologyOctober 2017;Evidence-Based Complementary & Alternative Med.2017Food Chemistry.2015 Feb.7.Phytomedicine1 Feb. 2018;
Evid Based Complement Alternat Med. 2017:1583185Front Plant Sci. 2017 May 8;Auburn, Alabama2015 Aug 1Braz J Med Biol Res. 2016 Jul 4;49(7).
Our products had been exported to the following research institutions and universities, And still growing.
Mendel University in Brno (Czech Republic)National Cancer Institute (USA)Texas A&M University (USA)Kyoto University (Japan)
University of Sao Paulo (Brazil)Universita' Degli Studi Di Cagli... (Italy)Universidade Federal de Goias (U... (Brazil)Auburn University (USA)
Srinakharinwirot University (Thailand)National Chung Hsing University (Taiwan)University of Hertfordshire (United Kingdom)
||1. Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.|
||The herbs of Galium aparine L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Deoxyvasicinone References Information
Methods. 2015 Jan;71:71-6.
|Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.[Pubmed: 25196325]|
|NEDD8-activating enzyme (NAE) controls the specific degradation of proteins regulated by cullin-RING ubiquitin E3 ligases, and has been considered as an attractive molecular target for the development of drugs against cancer. A pharmacophore model constructed from a training set of Deoxyvasicinone derivatives was used to screen 376 compounds from an analogue database. From the initial screening, the valine-linked Deoxyvasicinone derivative 9 and the N-isopropyl-linked Deoxyvasicinone derivative 10 emerged as the top scoring candidates. Compounds 9 and 10 showed micromolar potencies in both cell-free and cell-based systems, with selectivity for NAE over the related enzymes SAE and UAE. Molecular modelling analysis suggested that 9 and 10 may inhibit NAE by blocking the ATP-binding domain. Thus, these Deoxyvasicinone derivatives could be considered as promising lead molecules for the development of more potent inhibitors of NAE.