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    Dihydrolycorine
    Information
    CAS No. 6271-21-2 Price $318 / 20mg
    Catalog No.CFN90331Purity>=98%
    Molecular Weight289.33Type of CompoundAlkaloids
    FormulaC16H19NO4Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. It protects against anoxia damage of brain in rat.Dihydrolycorine-HCL shows hypotensive effects, it can block alpha 1-adrenoceptors.
    Targets: Adrenergic Receptor
    In vivo:
    Journal of Yunyang Medical College, 2002 , 21 (2) :71-72.
    Protective Effects of Dihydrolycorine on the Anoxia Brain Damage in Rat[Reference: WebLink]
    To investigate the effect of Dihydrolycorine on anoxia brain damage in rats.
    METHODS AND RESULTS:
    The model of hyperbicarbonatemia was used by stopping respirator to record the reemerge time and recovery percentage of EEG during reoxygenation for 10 minutes. Results The recovery percentage of control, DL(20 mg/kg), DL(40 mg/kg), nimodipine group is respectively (32.15±33.68)%, (75.40±17.12)%, (62.50±15.81)%, (80.00±12.26)%, which showed that the drug administered markedly improved recovery of the amplitude of EEG after reoxygenation compared with the controls.
    CONCLUSIONS:
    It suggests that DL and nimodipine protects against anoxia damage of brain in rat.
    Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.
    Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed: 944052]

    METHODS AND RESULTS:
    The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above.
    CONCLUSIONS:
    It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.
    Dihydrolycorine Description
    Source: The bulbus of Lycoris radiata (L. Herit.) Herb
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4563 mL 17.2813 mL 34.5626 mL 69.1252 mL 86.4065 mL
    5 mM 0.6913 mL 3.4563 mL 6.9125 mL 13.825 mL 17.2813 mL
    10 mM 0.3456 mL 1.7281 mL 3.4563 mL 6.9125 mL 8.6407 mL
    50 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.3825 mL 1.7281 mL
    100 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6913 mL 0.8641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.
    Hypotensive effect of dihydrolycorine.[Pubmed: 8503287]
    Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb.
    METHODS AND RESULTS:
    DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively.
    CONCLUSIONS:
    These results suggest that DL can block alpha 1-adrenoceptors.