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    Elemicin
    Information
    CAS No. 487-11-6 Price $40 / 20mg
    Catalog No.CFN90685Purity>=98%
    Molecular Weight208.3Type of CompoundPhenylpropanoids
    FormulaC12H16O3Physical DescriptionOil
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Elemicin has anticancer, and antifungal activities, it exhibits anticholinergic-like effects in humans.
    Targets: Antifection
    In vivo:
    Chem Res Toxicol. 2012 Nov 19;25(11):2352-67.
    Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.[Pubmed: 22992039]
    The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene Elemicin (3,4,5-trimethoxyallylbenzene) in rat and human, based on the PBK models previously developed for the structurally related alkenylbenzenes estragole, methyleugenol, and safrole.
    METHODS AND RESULTS:
    Using the newly developed models, the level of metabolic activation of Elemicin in rat and human was predicted to obtain insight in species differences in the bioactivation of Elemicin and read across to the other methoxy allylbenzenes, estragole and methyleugenol. Results reveal that the differences between rat and human in the formation of the proximate carcinogenic metabolite 1'-hydroxyElemicin and the ultimate carcinogenic metabolite 1'-sulfoxyElemicin are limited (<3.8-fold). In addition, a comparison was made between the relative importance of bioactivation for Elemicin and that of estragole and methyleugenol. Model predictions indicate that compound differences in the formation of the 1'-sulfoxymetabolites are limited (<11-fold) in rat and human liver. The insights thus obtained were used to perform a risk assessment for Elemicin using the margin of exposure (MOE) approach and read across to the other methoxy allylbenzene derivatives for which in vivo animal tumor data are available. This reveals that Elemicin poses a lower priority for risk management as compared to its structurally related analogues estragole and methyleugenol.
    CONCLUSIONS:
    Altogether, the results obtained indicate that PBK modeling provides an important insight in the occurrence of species differences in the metabolic activation of Elemicin. Moreover, they provide an example of how PBK modeling can facilitate a read across in risk assessment from compounds for which in vivo toxicity studies are available to a compound for which only limited toxicity data have been described, thus contributing to the development of alternatives for animal testing.
    Elemicin Description
    Source: The leaves of Perilla frutescens (L.) Britt.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8008 mL 24.0038 mL 48.0077 mL 96.0154 mL 120.0192 mL
    5 mM 0.9602 mL 4.8008 mL 9.6015 mL 19.2031 mL 24.0038 mL
    10 mM 0.4801 mL 2.4004 mL 4.8008 mL 9.6015 mL 12.0019 mL
    50 mM 0.096 mL 0.4801 mL 0.9602 mL 1.9203 mL 2.4004 mL
    100 mM 0.048 mL 0.24 mL 0.4801 mL 0.9602 mL 1.2002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.