ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Evid Based Complement Alternat Med. 2017:6360836.Anticancer Res.2014 Jul;34(7):3505-9.Phytomedicine. 2017 Jan 15;J Biochem Mol Toxicol. 2017 Jun 7Evid Based Complement Alternat Med. 2018;
J Ethnopharmacol. 2017 Jul 12;Planta Med 2016 Apr 28.Phytother Res.2018 Jan 29.SBRAS2016(12)Evid Based Complement Alternat Med. 2017:1583185
Curr Eye Res.2018 Jan;Pharmacological Reports31 May 2017Biomed Chromatogr. 2016 Mar 23.Sci Rep. 2017 Jun 12;
Our products had been exported to the following research institutions and universities, And still growing.
Monash University (Australia)University of Brasilia (Brazil)Instituto de Investigaciones Agr... (Chile)Lund University (Sweden)
Universidade de Franca (Brazil)St. Jude Children Research Hospi... (USA)Molecular Biology Institute of B... (Spain)Periyar University (India)
Osmania University (India)Washington State University (USA)University of Wisconsin-Madison (USA)
||Elemicin has anticancer, and antifungal activities, it exhibits anticholinergic-like effects in humans.|
|Chem Res Toxicol. 2012 Nov 19;25(11):2352-67. |
|Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.[Pubmed: 22992039]|
|The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene Elemicin (3,4,5-trimethoxyallylbenzene) in rat and human, based on the PBK models previously developed for the structurally related alkenylbenzenes estragole, methyleugenol, and safrole. |
METHODS AND RESULTS:
Using the newly developed models, the level of metabolic activation of Elemicin in rat and human was predicted to obtain insight in species differences in the bioactivation of Elemicin and read across to the other methoxy allylbenzenes, estragole and methyleugenol. Results reveal that the differences between rat and human in the formation of the proximate carcinogenic metabolite 1'-hydroxyElemicin and the ultimate carcinogenic metabolite 1'-sulfoxyElemicin are limited (<3.8-fold). In addition, a comparison was made between the relative importance of bioactivation for Elemicin and that of estragole and methyleugenol. Model predictions indicate that compound differences in the formation of the 1'-sulfoxymetabolites are limited (<11-fold) in rat and human liver. The insights thus obtained were used to perform a risk assessment for Elemicin using the margin of exposure (MOE) approach and read across to the other methoxy allylbenzene derivatives for which in vivo animal tumor data are available. This reveals that Elemicin poses a lower priority for risk management as compared to its structurally related analogues estragole and methyleugenol.
Altogether, the results obtained indicate that PBK modeling provides an important insight in the occurrence of species differences in the metabolic activation of Elemicin. Moreover, they provide an example of how PBK modeling can facilitate a read across in risk assessment from compounds for which in vivo toxicity studies are available to a compound for which only limited toxicity data have been described, thus contributing to the development of alternatives for animal testing.
||The leaves of Perilla frutescens (L.) Britt.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.