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    Eupalinolide A
    Eupalinolide A
    Information
    CAS No. 877822-41-8 Price $238 / 20mg
    Catalog No.CFN90381Purity>=98%
    Molecular Weight462.49Type of CompoundSesquiterpenoids
    FormulaC24H30O9Physical DescriptionCryst.
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Eupalinolide A Description
    Source: The herbs of Eupatorium lindleyanum DC.
    Biological Activity or Inhibitors: 1. Eupalinolide A and Eupalinolide B induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90.
    2. Eupalinolide A and Eupalinolide B could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1622 mL 10.811 mL 21.6221 mL 43.2442 mL 54.0552 mL
    5 mM 0.4324 mL 2.1622 mL 4.3244 mL 8.6488 mL 10.811 mL
    10 mM 0.2162 mL 1.0811 mL 2.1622 mL 4.3244 mL 5.4055 mL
    50 mM 0.0432 mL 0.2162 mL 0.4324 mL 0.8649 mL 1.0811 mL
    100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.4324 mL 0.5406 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Eupalinolide A References Information
    Citation [1]

    J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 16;995-996C:1-7.

    Pharmacokinetics of eupalinolide A, eupalinolide B and hyperoside from Eupatorium lindleyanum in rats by LC/MS/MS.[Pubmed: 26011510]
    A simple, selective, and sensitive LC/MS/MS method was developed and validated for simultaneous determination of Eupalinolide A, eupalinolide B, and hyperoside in rat plasma. Plasma samples were processed by protein precipitation with acetonitrile. The three analytes, together with internal standard (IS, lysionotin), were separated on a Venusil MP-C18 column (50mm×2.1mm, 3μm) using a mobile phase of methanol and 10mM ammonium acetate (45:55, v/v) with isocratic elution. Mass spectrometric detection was performed by multiple-reaction monitoring mode via electrospray ionization source. Linear calibration curves were obtained for the following concentration range: 1.28-640ng/mL for Eupalinolide A; 1.98-990ng/mL for EB; and 2.00-1000ng/mL for HYP. The intra- and inter-day precision was less than 10.25%, and the accuracy was between 89.16% and 110.63%. The extraction recovery of the analytes and IS from rat plasma was above 88.75%. The validated method has been successfully applied to pharmacokinetic studies of the three analytes following intragastric administration of Eupatorium lindleyanum extract at a single dose of 100, 250, and 625mg/kg to Sprague-Dawley rats, respectively. The pharmacokinetic results may help to better understand the pharmacological actions of the herb E. lindleyanum.
    Citation [2]

    Biochem Pharmacol. 2012 Apr 1;83(7):909-22.

    Purification and characterization of HSP-inducers from Eupatorium lindleyanum.[Pubmed: 22245466]
    The expression of heat shock proteins (HSPs), particularly HSP70, provides resistance to stressors. We recently reported that ultraviolet (UV)-induced melanin production and skin damage were suppressed in transgenic mice expressing HSP70 and that an extract of Eupatorium lindleyanum induces the expression of HSP70 in cells. Here we report the purification of Eupalinolide A and B (EA and EB) from E. lindleyanum, and describe their actions as HSP-inducers. Eupalinolide A and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability. Treatment of cells with Eupalinolide A or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the Eupalinolide A - or EB-mediated induction of HSP70 expression. Furthermore, EB inhibited the interaction between HSF1 and HSP90, which is known to inhibit the activity of HSF1. These findings suggest that Eupalinolide A and EB induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. Eupalinolide A and EB both induced the expression of HSP70 synergistically with other stressors. Furthermore, pre-treatment of cells with Eupalinolide A or EB suppressed melanin production and stressor-induced apoptosis. These effects were suppressed by the artificial suppression of HSP70 expression. In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin. These results suggest that Eupalinolide A and EB could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.