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    Euphorbia factor L2
    Euphorbia factor L2
    Information
    CAS No. 218916-51-9 Price
    Catalog No.CFN92884Purity>=98%
    Molecular Weight642.7Type of CompoundDiterpenoids
    FormulaC38H42O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: Euphorbia factor L2 shows cytotoxic activity against lung carcinoma A549 cells, it induces apoptosis through a mitochondrial pathway.
    Targets: ROS | Caspase | PARP | P450 (e.g. CYP17)
    Euphorbia factor L2 Description
    Source: The herbs of Euphorbia pekinensis Rupr.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

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    IF=22.415(2019)

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    IF=14.548(2019)

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    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5559 mL 7.7797 mL 15.5594 mL 31.1187 mL 38.8984 mL
    5 mM 0.3112 mL 1.5559 mL 3.1119 mL 6.2237 mL 7.7797 mL
    10 mM 0.1556 mL 0.778 mL 1.5559 mL 3.1119 mL 3.8898 mL
    50 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.6224 mL 0.778 mL
    100 mM 0.0156 mL 0.0778 mL 0.1556 mL 0.3112 mL 0.389 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Acta Pharm Sin B. 2017 Jan;7(1):59-64.
    Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway.[Pubmed: 28119809 ]
    Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced.
    METHODS AND RESULTS:
    We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species (ROS) generation, a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway.
    CONCLUSIONS:
    The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds.
    Structure Identification:
    Journal of Pharmaceutical and Biomedical Analysis.2013 Jan 18;72(18):299–305.
    A sensitive liquid chromatography–mass spectrometry method for simultaneous determination of three diterpenoid esters from Euphorbia lathyris L. in rat plasma.[Reference: WebLink]
    A selective and sensitive liquid chromatography–mass spectrometry (LC–MS) method was developed for the simultaneous determination of Euphorbia factor L1, Euphorbia factor L2 and Euphorbia factor L3 from Euphorbiae semen in rat plasma.
    METHODS AND RESULTS:
    Larotaxel was added to a 200 μL plasma sample as the internal standard (IS). The plasma sample was extracted by 2 mL ether and separated on an Elite C18 column (150 mm × 4.6 mm, 5 μm) with the mobile phase of methanol–water performing gradient elution within 11.0 min. All the three analytes were detected in the selected ion monitoring (SIM) mode with positive electrospray ionization. The calibration curves were linear in the range of 2.0–200 ng/mL and the lower limits of quantification (LLOQ) were 2.0 ng/mL for all the three analytes. The intra-day and inter-day precisions were all within 8.6% and 14.6% for the three analytes, while the accuracy was less than 9.7% and 7.5%, respectively.
    CONCLUSIONS:
    The validated method was firstly and successfully applied to the pharmacokinetic study of Euphorbia factor L1, Euphorbia factor L2 and Euphorbia factor L3 from Euphorbiae semen after oral administration in rat plasma.