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    Febrifugine
    Febrifugine
    Information
    CAS No. 24159-07-7 Price $588 / 10mg
    Catalog No.CFN92302Purity>=98%
    Molecular Weight301.3Type of CompoundAlkaloids
    FormulaC16H19N3O3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Febrifugine

    Catalog No: CFN92302
    CAS No: 24159-07-7
    Price: $588/10mg
    Febrifugine Description
    Source: The roots of Dichroa febrifuga
    Biological Activity or Inhibitors: 1. Febrifugine is an effective coccidiostat, possesses schizonticide props.
    2. Febrifugine and its derivatives shows high degree of antimalarial activity but use limited by toxicity .
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.319 mL 16.5948 mL 33.1895 mL 66.379 mL 82.9738 mL
    5 mM 0.6638 mL 3.319 mL 6.6379 mL 13.2758 mL 16.5948 mL
    10 mM 0.3319 mL 1.6595 mL 3.319 mL 6.6379 mL 8.2974 mL
    50 mM 0.0664 mL 0.3319 mL 0.6638 mL 1.3276 mL 1.6595 mL
    100 mM 0.0332 mL 0.1659 mL 0.3319 mL 0.6638 mL 0.8297 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Febrifugine References Information
    Citation [1]

    Sci Transl Med. 2015 May 20;7(288):288ra77.

    The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.[Pubmed: 25995223]
    We demonstrate that the cytoplasmic prolyl-tRNA (transfer RNA) synthetase (PfcPRS) of the malaria parasite Plasmodium falciparum is a biochemical and functional target of Febrifugine and its synthetic derivative halofuginone. Febrifugine is the active principle of a traditional Chinese herbal remedy for malaria. We show that treatment with Febrifugine derivatives activated the amino acid starvation response in both P. falciparum and a transgenic yeast strain expressing PfcPRS. We further demonstrate in the Plasmodium berghei mouse model of malaria that halofuginol, a new halofuginone analog that we developed, is active against both liver and asexual blood stages of the malaria parasite. Halofuginol, unlike halofuginone and Febrifugine, is well tolerated at efficacious doses and represents a promising lead for the development of dual-stage next-generation antimalarials.
    Citation [2]

    J Adv Pharm Technol Res. 2013 Jan;4(1):50-60.

    Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent.[Pubmed: 23662282]
    Febrifugine and its derivatives are effective against Plasmodium falciparum. Using PHASE algorithm, a five-point pharmacophore model with two hydrogen bond acceptor (A), one positively ionizable (P) and two aromatic rings (R), was developed to derive a predictive ligand-based statistically significant 3D-quantitative structure-activity relationship (QSAR) model (r(2) = 0.972, SD = 0.3, F = 173.4, Q(2) = 0.712, RMSE = 0.3, Person-R = 0.94, and r(2) pred = 0.8) to explicate the structural attributes crucial for antimalarial activity. The developed pharmacophore model and 3D QSAR model can be a substantial tool for virtual screening and related antimalarial drug discovery research.
    Citation [3]

    Southeast Asian J Trop Med Public Health. 2008 Nov;39(6):949-58.

    Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment.[Pubmed: 19062681]
    Parasitemia patterns, survival and cytokine levels of Plasmodium berghei NK65-infected BALB/c mice, treated orally with the alkaloidal mixture of Febrifugine and isoFebrifugine at a dose of 1 mg/kg twice a day for 4 consecutive days were monitored. Whereas the untreated mice showed a progressive increase in parasitemia and ultimate death, the alkaloid mixture-treated group showed a transient suppression of parasitemia during the course of treatment.