ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J-STAGE2015, 249-255Sci Rep.2015, 5:13194Eur J Pharm Sci.2016, 94:33-45Mol Pharm.2017, 14(9):3164-3177Phytochemistry.2017, 141:162-170International. J. of Food Propert...2017...Evid Based Complement Alternat Me...2017...Mol Cell.2017, 68(4):673-685
Asian J of Pharmaceutical&Clinica...2018...Molecules.2018, 23(10):E2638Molecules.2018, 23(12):E3103The Journal of Agromedicine and M...2018...J Nat Med.2018, 72(3):734-744Int J Mol Sci.2019, 20(14):E3538Nat Prod Sci.2019, 25(3):238FASEB J.2019, 33(2):2026-2036
Academic J of Second Military Med...2019...Phytomedicine.2019, 65:153089J of Applied Pharmaceutical Scien...2020...Genes Genomics.2020, 10.1007Pharmacological Reports2020, 1-9J Sep Sci.2020, 201901140J Ethnopharmacol.2020, 249:112396
Our products had been exported to the following research institutions and universities, And still growing.
Chulalongkorn University (Thailand)Universite de Lille1 (France)University of Virginia (USA)Indian Institute of Science (India)
Melbourne University (Australia)University of Maryland (USA)Wroclaw Medical University (Poland)Univerzita Karlova v Praze (Czech Republic)
Centralised Purchases Unit (CPU... (India)Regional Crop Research Institute (Korea)Kamphaengphet Rajabhat University (Thailand)
Related Screening Libraries
|| Reference standards.|
Frangulin A Description
||The barks of Rhamnus frangula L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Magnetic Resonance in Chemistry, 1998, 36(10):769-772. |
|Assignment of the 1H and 13C NMR spectra of anthraquinone glycosides from Rhamnus frangula.[Reference: WebLink]|
|1H and 13C NMR chemical shifts are reported for five anthraquinone glycosides from Rhamnus frangula (Alder Buckthorn).
METHODS AND RESULTS:
The investigation utilized data obtained by a variety of 1D and 2D NMR techniques such as homodecoupling, NOE, J‐modulated spin‐echo, COSY, HSC and COLOC. Assignments were made for Frangulin A and frangulin B and glucoFrangulin A and B. A further compound previously thought to be a glycoside of emodin is shown to be physcion‐8‐O‐β‐D‐glucoside.
|Planta Med 2013; 79 - PK33. |
|New HPLC – method to determine Frangulin A and B as well as Glucofrangulin A and B in Frangulae cortex.[Reference: WebLink]|
|The current monograph in the European Pharmacopeia for Frangulae cortex describes a photometric assay based on an adapted bornträger reaction to determine hydroxyanthracene glycosides, calculated as frangulin B. The method is time consuming, unspecific for frangulines and the precision is not adequate for a modern assay. The photometric method shall therefore be replaced by a modern HPLC-method. There is no HPLC method published in the literature that allows the determination of Frangulin A/frangulin B and glucoFrangulin A/glucofrangulin B in Frangulae cortex.
METHODS AND RESULTS:
About 300 mg of freshly milled drug are extracted for 15 min with ultrasound. The extraction solution consists of acetonitrile/water 50:50 v/v and 2 g/L NaHCO3. A conventional RP C18 Nucleodur (4 mm x 125 mm), 3 µm was used as stationary phase. Mobile phase A consists of water (pH of 2.0, adjusted with phosphoric acid). Mobile phase B consists acetonitrile/methanol 20:80 v/v. The flow rate is 1.0 mL/min, the detection wavelength 435nm, the column temperature is 50 °C, and the injection volume 20µL. The gradient is shown in table 1.
The mobile phase separates the four frangulins sufficiently. Results of several samples will be presented on the poster. A chromatogram from a Frangulae cortex sample is shown in figure 1.