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    Frangulin A
    Frangulin A
    Information
    CAS No. 521-62-0 Price
    Catalog No.CFN70393Purity>=98%
    Molecular Weight416.4Type of CompoundAnthraquinones
    FormulaC21H20O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anthraquinones Compound Library
  • Biological Activity
    Description: Reference standards.
    Frangulin A Description
    Source: The barks of Rhamnus frangula L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4015 mL 12.0077 mL 24.0154 mL 48.0307 mL 60.0384 mL
    5 mM 0.4803 mL 2.4015 mL 4.8031 mL 9.6061 mL 12.0077 mL
    10 mM 0.2402 mL 1.2008 mL 2.4015 mL 4.8031 mL 6.0038 mL
    50 mM 0.048 mL 0.2402 mL 0.4803 mL 0.9606 mL 1.2008 mL
    100 mM 0.024 mL 0.1201 mL 0.2402 mL 0.4803 mL 0.6004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Magnetic Resonance in Chemistry, 1998, 36(10):769-772.
    Assignment of the 1H and 13C NMR spectra of anthraquinone glycosides from Rhamnus frangula.[Reference: WebLink]
    1H and 13C NMR chemical shifts are reported for five anthraquinone glycosides from Rhamnus frangula (Alder Buckthorn).
    METHODS AND RESULTS:
    The investigation utilized data obtained by a variety of 1D and 2D NMR techniques such as homodecoupling, NOE, J‐modulated spin‐echo, COSY, HSC and COLOC. Assignments were made for Frangulin A and frangulin B and glucoFrangulin A and B. A further compound previously thought to be a glycoside of emodin is shown to be physcion‐8‐O‐β‐D‐glucoside.
    Planta Med 2013; 79 - PK33.
    New HPLC – method to determine Frangulin A and B as well as Glucofrangulin A and B in Frangulae cortex.[Reference: WebLink]
    The current monograph in the European Pharmacopeia for Frangulae cortex describes a photometric assay based on an adapted bornträger reaction to determine hydroxyanthracene glycosides, calculated as frangulin B. The method is time consuming, unspecific for frangulines and the precision is not adequate for a modern assay. The photometric method shall therefore be replaced by a modern HPLC-method. There is no HPLC method published in the literature that allows the determination of Frangulin A/frangulin B and glucoFrangulin A/glucofrangulin B in Frangulae cortex.
    METHODS AND RESULTS:
    About 300 mg of freshly milled drug are extracted for 15 min with ultrasound. The extraction solution consists of acetonitrile/water 50:50 v/v and 2 g/L NaHCO3. A conventional RP C18 Nucleodur (4 mm x 125 mm), 3 µm was used as stationary phase. Mobile phase A consists of water (pH of 2.0, adjusted with phosphoric acid). Mobile phase B consists acetonitrile/methanol 20:80 v/v. The flow rate is 1.0 mL/min, the detection wavelength 435nm, the column temperature is 50 °C, and the injection volume 20µL. The gradient is shown in table 1.
    CONCLUSIONS:
    The mobile phase separates the four frangulins sufficiently. Results of several samples will be presented on the poster. A chromatogram from a Frangulae cortex sample is shown in figure 1.