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    Friedelin 3,4-lactone
    Friedelin 3,4-lactone
    Information
    CAS No. 29621-75-8 Price
    Catalog No.CFN89057Purity>=98%
    Molecular Weight442.72Type of CompoundTriterpenoids
    FormulaC30H50O2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Friedelin-3,4-lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs).
    In vitro:
    Journal of Yunnan University, 2010,32 (6) :690-694.
    Separation,structural characterization and inducing proliferation activity of Friedelin-3,4-lacton from Calophyllum polyanthum.[Reference: WebLink]

    METHODS AND RESULTS:
    The methanol extract of the dried leaf of Calophyllum polyanthum was partitioned successively with petroleum ether and ethyl acetate. Petroleum ether fraction was gradient eluted over silica gel column using 9:1 petroleum ether-ethyl acetate as eluant to give a rod crystal and three known compounds.The rod crystal was characterized by IR,1H NMR,13C NMR,MS and X-ray single crystal diffraction.
    CONCLUSIONS:
    The results showed that the crystal was Friedelin 3,4-lactone,and the molecular formula was C30H50O2.Its bioactivity was measured by MTT assay.The results proved that triterpenoid lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs).
    Friedelin 3,4-lactone Description
    Source: The leaves of Garcia parviflora.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2588 mL 11.2938 mL 22.5876 mL 45.1753 mL 56.4691 mL
    5 mM 0.4518 mL 2.2588 mL 4.5175 mL 9.0351 mL 11.2938 mL
    10 mM 0.2259 mL 1.1294 mL 2.2588 mL 4.5175 mL 5.6469 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2010 Nov 29;73(11):1839-45.
    Triterpenes from Garcia parviflora. Cytotoxic evaluation of natural and semisynthetic friedelanes.[Pubmed: 20958014 ]
    Three new friedelane-type triterpenes, 1,2-dehydro-2,3-secofriedelan-3-oic acid (1), 1β-hydroxyfriedelin (2), and 3β-hydroxyfriedelan-23-oic acid (3), and the known compounds Friedelin 3,4-lactone (4), acetyl aleuritolic acid (5), 4-hydroxy-5-propionyl-1,3-di-O-methylpyrogallol, elemicin, and (-)-syringaresinol were isolated from the leaves of Garcia parviflora.
    METHODS AND RESULTS:
    The structures of 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR, HREIMS, X-ray, and CD analysis. Some derivatives of 2 (6-14) were prepared via oxidation, reduction, and esterification. The natural triterpenes and the semisynthetic friedelane derivatives were tested for cytotoxic activity against human cancer cell lines U251, PC-3, K562, HCT-15, MCF-7, and SKLU-1.
    CONCLUSIONS:
    Compound 5 was cytotoxic against U251 cells.