Fustin | CAS:20725-03-5 | Manufacturer ChemFaces

Fustin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Fustin
Price:
CAS No.:	20725-03-5
Catalog No.:	CFN98042
Molecular Formula:	C₁₅H₁₂O₆
Molecular Weight:	288.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The peels of Toxicodendron vernicifluum (Stokes) F. Barkley
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.

Targets:

Beta Amyloid | AChR | ERK | cAMP | PKC

In vivo:

J Neurosci Res. 2009 Dec;87(16):3658-70.

Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.[Pubmed: 19533734]

Natural flavonoids ameliorate amyloid-beta peptide (Abeta)-induced neurotoxicity.
METHODS AND RESULTS:
We examined whether the Fustin flavonoid affects Abeta-induced learning impairment in mice. Repeated treatment with Fustin significantly attenuated Abeta (1-42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Abeta (1-42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Abeta (1-42). In addition, Fustin significantly attenuated Abeta (1-42)-induced selective decreases in muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity (as determined by [(3)H]pirenzepine binding) by modulating extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response-element binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression. These effects of Fustin were reversed by treatment with dicyclomine, a muscarinic M1 receptor antagonist, and SL327, a selective ERK inhibitor, but not by chelerythrine, a pan-protein kinase C (PKC) inhibitor.
CONCLUSIONS:
Taken together, our results suggest that Fustin attenuates Abeta (1-42)-impaired learning, and that the ERK/CREB/BDNF pathway is important for the M1 receptor-mediated cognition-enhancing effects of Fustin.

Fustin Description

Source:	The peels of Toxicodendron vernicifluum (Stokes) F. Barkley
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library PKC Inhibitor Library ERK Inhibitor Library cAMP Inhibitor Library Beta Amyloid Inhibitor Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4686 mL	17.343 mL	34.6861 mL	69.3722 mL	86.7152 mL
5 mM	0.6937 mL	3.4686 mL	6.9372 mL	13.8744 mL	17.343 mL
10 mM	0.3469 mL	1.7343 mL	3.4686 mL	6.9372 mL	8.6715 mL
50 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.3874 mL	1.7343 mL
100 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.6937 mL	0.8672 mL

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