ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
How to Order
Orders via your E-mail:
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2. Delivery address
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4. Contact information
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Sci Rep. 2017 Jun 12;Food Analytical Methods07 April 2017Chem Biol Interact. 2016 Dec 25Sci Rep. 2016; 6: 25094.2016 Apr 27;6:25094. J Chromatogr Sci.2015 Feb 5. pii: bmu231.
BMC Pharmacol Toxicol. 2018 Jan 31;Clin Exp Pharmacol Physiol.2015 Aug 1Appl Microbiol Biotechnol. 2015 Dec 21. Polytechnic University of Catalonia2016Chem Biol Interact.2018 Mar 1;
Hindawi Publishing Corporation2015 July 30Sci Rep. 2018 Jan 11;RSC AdvancesIssue 86, 2017BMC Complement Altern Med.2016 Jul 13
Our products had been exported to the following research institutions and universities, And still growing.
Lodz University of Technology (Poland)Periyar University (India)University of Bonn (Germany)Chungnam National University (Korea)
Sri Ramachandra University (India)Weizmann Institute of Science (Israel)Ain Shams University (Egypt)FORTH-IMBB (Greece)
Technical University of Denmark (Denmark)University of South Australia (Australia)Monash University (Australia)
||Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.|
||Beta Amyloid | AChR | ERK | cAMP | PKC|
|J Neurosci Res. 2009 Dec;87(16):3658-70. |
|Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.[Pubmed: 19533734]|
Natural flavonoids ameliorate amyloid-beta peptide (Abeta)-induced neurotoxicity.|
METHODS AND RESULTS:
We examined whether the Fustin flavonoid affects Abeta-induced learning impairment in mice. Repeated treatment with Fustin significantly attenuated Abeta (1-42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Abeta (1-42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Abeta (1-42). In addition, Fustin significantly attenuated Abeta (1-42)-induced selective decreases in muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity (as determined by [(3)H]pirenzepine binding) by modulating extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response-element binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression. These effects of Fustin were reversed by treatment with dicyclomine, a muscarinic M1 receptor antagonist, and SL327, a selective ERK inhibitor, but not by chelerythrine, a pan-protein kinase C (PKC) inhibitor.
Taken together, our results suggest that Fustin attenuates Abeta (1-42)-impaired learning, and that the ERK/CREB/BDNF pathway is important for the M1 receptor-mediated cognition-enhancing effects of Fustin.
||The peels of Toxicodendron vernicifluum (Stokes) F. Barkley
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.