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    Ganolucidic acid A
    Information
    CAS No. 98665-21-5 Price
    Catalog No.CFN90299Purity>=98%
    Molecular Weight500.67Type of CompoundTriterpenoids
    FormulaC30H44O6Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
    Targets: HIV
    In vitro:
    Chem. Pharm .Bull., 1998, 46(10):1607-12.
    Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.[Pubmed: 9810695]
    Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known.
    METHODS AND RESULTS:
    The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3 beta,7 beta-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore.
    CONCLUSIONS:
    Of the compound isolated, ganoderic acid beta, (24S)-lanosta-7,9(11)-diene-3 beta,24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and Ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
    Ganolucidic acid A Description
    Source: The fruit body of Ganoderma lucidum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9973 mL 9.9866 mL 19.9732 mL 39.9465 mL 49.9331 mL
    5 mM 0.3995 mL 1.9973 mL 3.9946 mL 7.9893 mL 9.9866 mL
    10 mM 0.1997 mL 0.9987 mL 1.9973 mL 3.9946 mL 4.9933 mL
    50 mM 0.0399 mL 0.1997 mL 0.3995 mL 0.7989 mL 0.9987 mL
    100 mM 0.02 mL 0.0999 mL 0.1997 mL 0.3995 mL 0.4993 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chemical & pharmaceutical bulletin 33(6), 2628-2631, 1985-06-25
    GANODERIC ACID G AND I AND GANOLUCIDIC ACID A AND B, NEW TRITERPENOIDS FROM GANODERMA LUCIDUM[Reference: WebLink]

    METHODS AND RESULTS:
    Four new highly oxidized lanostane-type triterpenoids, ganoderic acid G and I and Ganolucidic acid A and B, were isolated from the fungus ganoderma lucidum and their structures were elucidated on the basis of spectral evidence.