ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Int J Mol Sci. 2017 May 11;Oncotarget. 2016 Aug 19Viruses. 2017 Oct 3;9(10). Experimental Parasitology2015 March 24.J. Acta Agr. Scandinavica17 Apr 2017
Phytochemistry Letters2015 JuneJ Chromatogr B Analyt Tec. Bio. Life Sci. 2017 Oct 1;Polytechnic University of Catalonia2016J Pharm Biomed Anal.2018 Mar 20;Front Plant Sci. 2017 May 8;
Sci Rep. 2017 Dec 11;Acta Pharmaceutica Sinica B2015 Apr.7.J Nat Med.2017 Jul 5. JPCJuly 12, 2017
Our products had been exported to the following research institutions and universities, And still growing.
Tokyo Woman's Christian University (Japan)Mahatma Gandhi University (India)Uniwersytet Gdański (Poland)Chungnam National University (Korea)
Rio de Janeiro State University (Brazil)Sapienza University of Rome (Italy)Calcutta University (India)Max-Planck-Insitut (Germany)
Kamphaengphet Rajabhat University (Thailand)Julius Kühn-Institut (Germany)Universidad Veracuzana (Mexico)
|| Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.|
||p53 | p21|
|Anticancer Res. 1999 Jan-Feb;19(1A):487-91. |
|Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells.[Pubmed: 10226587]|
METHODS AND RESULTS:
In this paper, we present evidence that Ginsenoside Rs3 (G-Rs3), a new diol-type ginseng saponin isolated from the roots of Panax ginseng C.A. Meyer, efficiently arrests the cell cycle at the G1/S boundary at lower doses, 0.1-5 microM, but induces apoptosis at higher doses, 10-25 microM, the effects of which were associated with selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells. The cell growth suppressive and apoptosis inducing effects were confirmed by MTT assays together with flow cytometric analyses, morphological changes and DNA fragmentation. Immunoblotting showed that Ginsenoside Rs3 significantly elevated protein levels of p53 and p21WAF1 prior to inducing apoptosis, while it did not elevate those of cyclin E, cyclin A, p27Kip1, and PCNA. Immune complex kinase assays showed that Ginsenoside Rs3 downregulated the activities of both cyclins E- and A-associated kinases.
Collectively, we suggest that Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 and hence downregulates the activities of the cyclin-dependent kinases, resulting in cell cycle arrest at the G1/S boundary. We also propose that apoptosis induced by Ginsenoside Rs3 is related to the elevations of p53 and p21WAF1 in the cells.
Ginsenoside Rs3 Description
||The roots of Panax ginseng C. A. Mey.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.