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    Ginsenoside Rs3
    Information
    CAS No. 194861-70-6 Price
    Catalog No.CFN92813Purity>=98%
    Molecular Weight827.1Type of CompoundTriterpenoids
    FormulaC44H74O14Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
    Targets: p53 | p21
    In vitro:
    Anticancer Res. 1999 Jan-Feb;19(1A):487-91.
    Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells.[Pubmed: 10226587]

    METHODS AND RESULTS:
    In this paper, we present evidence that Ginsenoside Rs3 (G-Rs3), a new diol-type ginseng saponin isolated from the roots of Panax ginseng C.A. Meyer, efficiently arrests the cell cycle at the G1/S boundary at lower doses, 0.1-5 microM, but induces apoptosis at higher doses, 10-25 microM, the effects of which were associated with selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells. The cell growth suppressive and apoptosis inducing effects were confirmed by MTT assays together with flow cytometric analyses, morphological changes and DNA fragmentation. Immunoblotting showed that Ginsenoside Rs3 significantly elevated protein levels of p53 and p21WAF1 prior to inducing apoptosis, while it did not elevate those of cyclin E, cyclin A, p27Kip1, and PCNA. Immune complex kinase assays showed that Ginsenoside Rs3 downregulated the activities of both cyclins E- and A-associated kinases.
    CONCLUSIONS:
    Collectively, we suggest that Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 and hence downregulates the activities of the cyclin-dependent kinases, resulting in cell cycle arrest at the G1/S boundary. We also propose that apoptosis induced by Ginsenoside Rs3 is related to the elevations of p53 and p21WAF1 in the cells.
    Ginsenoside Rs3 Description
    Source: The roots of Panax ginseng C. A. Mey.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.209 mL 6.0452 mL 12.0904 mL 24.1809 mL 30.2261 mL
    5 mM 0.2418 mL 1.209 mL 2.4181 mL 4.8362 mL 6.0452 mL
    10 mM 0.1209 mL 0.6045 mL 1.209 mL 2.4181 mL 3.0226 mL
    50 mM 0.0242 mL 0.1209 mL 0.2418 mL 0.4836 mL 0.6045 mL
    100 mM 0.0121 mL 0.0605 mL 0.1209 mL 0.2418 mL 0.3023 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.