ChemFaces is a professional high-purity natural products manufacturer.
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More articles cited ChemFaces products.
Cell Physiol Biochem.2017;43(4):1425-1435.Exp Parasitol.2017 Dec;Evidence-Based Complementary & Alternative Med.2017Pharm Biol. 2017 Dec;Oncotarget. 2016 Aug 19
Am J Chin Med.2016;44(6)Clin Exp Pharmacol Physiol.2015 Aug 1Int J Mol Sci. 2017 May 11;Auburn, Alabama2015 Aug 1Molecules.2013 Nov 14;18(11):14105-21.
Biochem Biophys Res Commun. 2018 Jan 1;Phytother Res.2015 Apr 17.Am J Chin Med.2015 Jul 30:1-22.J Biochem Mol Toxicol. 2017 Jun 7
Our products had been exported to the following research institutions and universities, And still growing.
University of Amsterdam (Netherlands)Martin Luther University of Hall... (Germany)Kyung Hee University (Korea)Warszawski Uniwersytet Medyczny (Poland)
Molecular Biology Institute of B... (Spain)Universidad Veracuzana (Mexico)University of Eastern Finland (Finland)Uniwersytet Gdański (Poland)
Donald Danforth Plant Science Ce... (USA)Utrecht University (Netherlands)Imperial College London (United Kingdom)
|| Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.|
||p53 | p21|
|Anticancer Res. 1999 Jan-Feb;19(1A):487-91. |
|Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells.[Pubmed: 10226587]|
METHODS AND RESULTS:
In this paper, we present evidence that Ginsenoside Rs3 (G-Rs3), a new diol-type ginseng saponin isolated from the roots of Panax ginseng C.A. Meyer, efficiently arrests the cell cycle at the G1/S boundary at lower doses, 0.1-5 microM, but induces apoptosis at higher doses, 10-25 microM, the effects of which were associated with selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells. The cell growth suppressive and apoptosis inducing effects were confirmed by MTT assays together with flow cytometric analyses, morphological changes and DNA fragmentation. Immunoblotting showed that Ginsenoside Rs3 significantly elevated protein levels of p53 and p21WAF1 prior to inducing apoptosis, while it did not elevate those of cyclin E, cyclin A, p27Kip1, and PCNA. Immune complex kinase assays showed that Ginsenoside Rs3 downregulated the activities of both cyclins E- and A-associated kinases.
Collectively, we suggest that Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 and hence downregulates the activities of the cyclin-dependent kinases, resulting in cell cycle arrest at the G1/S boundary. We also propose that apoptosis induced by Ginsenoside Rs3 is related to the elevations of p53 and p21WAF1 in the cells.
Ginsenoside Rs3 Description
||The roots of Panax ginseng C. A. Mey.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
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* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.