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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J of Food Quality2020, 8851285.J Chromatogr B Analyt Technol Bio...2019...Korean Herb. Med. Inf. 2016, 4(1):35-42Int J Mol Sci.2018, 19(9):E2825Eur J Pharmacol.2020, 889:173589.South African J of Plant&Soil...2018...Korean J of Medicinal Crop Scienc...2018...Chem. of Vegetable Raw Materials...2020...
Int. J. of Food Properties...2017...Nat Prod Commun.2017, 12(5):771-778Food Chem Toxicol.2020, 135:110863Korean J. Medicinal Crop Sci....2018...Front Immunol.2018, 9:2091Agronomy2020, 10(3),388.Evid Based Complement Alternat Me...2019...Molecules.2017, 22(2)
Braz J Med Biol Res. 2016, 49(7)Appl. Sci.2020, 10(5),1713.Molecules.2019, 24(6):E1155Biomedicine & Pharmacotherapy...2020...Analytical methods2019, 11(6)Phytomedicine.2017, 24:77-86Pharmacognosy Magazine...2017...
Our products had been exported to the following research institutions and universities, And still growing.
Imperial College London (United Kingdom)Centralised Purchases Unit (CPU... (India)Institute of Pathophysiology Me... (Austria)Istanbul University (Turkey)
Uniwersytet Gdański (Poland)University of Melbourne (Australia)CSIRO - Agriculture Flagship (Australia)Mahidol University (Thailand)
Monash University Malaysia (Malaysia)The Vancouver Prostate Centre (... (Canada)Copenhagen University (Denmark)
Related Screening Libraries
|| Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.|
||NO | PGE | NOS | COX | p65 | NF-kB | IkB | JNK | TNF-α | p38MAPK | IKK|
Goshonoside F5 Description
||The leaves of Japanese R. chingii.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Int Immunopharmacol. 2015 Feb;24(2):182-190. |
|Suppression of nuclear factor-kappa B and mitogen-activated protein kinase signalling pathways by goshonoside-F5 extracted from Rubi Fructus.[Pubmed: 25523460 ]|
Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine.|
METHODS AND RESULTS:
In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of Goshonoside F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeutic effect in a mouse endotoxic shock model. GF5 decreased NO and PGE2 production in LPS-stimulated macrophages (IC50=3.84 and 3.16μM). This effect involved the suppression of NOS-2 and COX-2 gene expression at the transcriptional level. Examination of the effects of GF5 on NF-κB signalling demonstrated that it inhibits the phosphorylation of IκB-α and IκB-β, blocking their degradation and the nuclear translocation of the NF-κB p65 subunit. Moreover, inhibition of MAPK signalling was also observed, and phosphorylation of p38 and JNK was suppressed in the presence of GF5. Inflammatory cytokines, including IL-6 and TNF-α, were down-regulated by this compound after activation with LPS (IC50=17.04 and 4.09μM). Additionally, GF5 (30 and 90mg/kg, i.p.) significantly reduced the circulating cytokine levels (IL-6 and TNF-α) and increased survival in a mouse model of endotoxemia.
These results show that GF5 significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. Our results provide a strong pharmacological basis for further understanding the potential therapeutic role of GF5 in inflammatory disease and shed new light on the bioactivity of ent-labdane diterpene glucoside.
|Chem Pharm Bull (Tokyo). 1987 Jul;35(7):3021-4. |
|Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus, and identification of the source plant of the Chinese folk medicine [Reference: WebLink]|
METHODS AND RESULTS:
Five diterpene glycosides, goshonoside F1, goshonoside F2, goshonoside F3, goshonoside F4 and Goshonoside F5(4-8), which are characteristic of the leaves of Japanese R. chingii(Gosho-ichigo), were isolated from the leaves of Chinese R. chingii(Zhan-yei fu-pen-zi). This proved the chemotaxonomical identity of the plants.
Compound 8 was also detected in commercial Chinese folk medicine, Fu-pen-xi, indicating that the source plant of this drug is R. chingii. Rubusoside (1), which is the sweet diterpene gfycoside of the leaves of R. suavissimus(Chinese name: Gan-yei xuen-gou-zi), was also identified in fruits of the plant.