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    Hastatoside
    Information
    CAS No. 50816-24-5 Price $268 / 20mg
    Catalog No.CFN96588Purity>=98%
    Molecular Weight404.37Type of CompoundIridoids
    FormulaC17H24O11Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Hastatoside and verbenalin are major sleep-promoting components of V. officinalis. Hastatoside has anti-inflammatory activity.
    Targets: Immunology & Inflammation related
    In vivo:
    Phytother Res. 2000 Sep;14(6):463-5.
    Antiinflammatory activity and chemical composition of extracts of Verbena officinalis.[Pubmed: 10960904]

    METHODS AND RESULTS:
    In an attempt to locate the biologically active fraction(s) of the plant Verbena officinalis Linn. (Verbenaceae), a preliminary screening of successive petroleum ether, chloroform and methanol extracts of aerial parts for antiinflammatory activity using carrageenan paw oedema model was carried out. All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of beta-sitosterol, ursolic acid, oleanolic acid, 3-epiursolic acid, 3-epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids.
    CONCLUSIONS:
    Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and Hastatoside, a phenylpropanoid glycoside, verbascoside and beta-sitosterol-D-glucoside.
    Sleep & Biological Rhythms, 2009, 7(3):211–217.
    Hastatoside and verbenalin are sleep‐promoting components in Verbena officinalis[Reference: WebLink]
    Herbal tea made from Verbena officinalis (V. officinalis) has traditionally been used for the treatment of insomnia and other nervous conditions.
    METHODS AND RESULTS:
    In this study, we examined the sleep-promoting activity of Hastatoside, verbenalin, and verbascoside, which are the major iridoids (Hastatoside and verbenalin) and polyphenol (verbascoside) components responsible for the pharmacological activity of V. officinalis, by electroencephalographic analysis of rats after oral administration of the compounds. Hastatoside (0.64 mmol/kg of body weight) and verbenalin (1.28 mmol/kg of body weight) increased the total time of non-rapid eye movement sleep during a 9-h period from 23.00 to 08.00 hours by 81% and 42%, respectively, with a lag time of about 3–5 h after the administration at 20.00 hours (lights-off time). Both compounds also increased the delta activity during non-rapid eye movement sleep. However, verbascoside had no effect on the amount of sleep.
    CONCLUSIONS:
    Therefore, Hastatoside and verbenalin are major sleep-promoting components of V. officinalis.
    Hastatoside Description
    Source: The herbs of Verbena officinalis L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.473 mL 12.3649 mL 24.7298 mL 49.4597 mL 61.8246 mL
    5 mM 0.4946 mL 2.473 mL 4.946 mL 9.8919 mL 12.3649 mL
    10 mM 0.2473 mL 1.2365 mL 2.473 mL 4.946 mL 6.1825 mL
    50 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9892 mL 1.2365 mL
    100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.