|Description:||1. Incensole acetate can inhibit Nuclear Factor-kappaB activation.|
2. Incensole acetate has protective effects on cerebral ischemic injury.
3. Incensole acetate can reduce depressive-like behavior and modulate hippocampal BDNF and CRF expression of submissive animals.
|Targets:||NF-kB | TRPV | TGF-β/Smad | TNF-α | IL Receptor|
|Source:||The resin of Boswellia carterii Birdw.|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.8694 mL||14.3472 mL||28.6944 mL||57.3888 mL||71.736 mL|
|5 mM||0.5739 mL||2.8694 mL||5.7389 mL||11.4778 mL||14.3472 mL|
|10 mM||0.2869 mL||1.4347 mL||2.8694 mL||5.7389 mL||7.1736 mL|
|50 mM||0.0574 mL||0.2869 mL||0.5739 mL||1.1478 mL||1.4347 mL|
|100 mM||0.0287 mL||0.1435 mL||0.2869 mL||0.5739 mL||0.7174 mL|
Nat Prod Commun. 2012 Mar;7(3):283-8.
|Efficient preparation of incensole and incensole acetate, and quantification of these bioactive diterpenes in Boswellia papyrifera by a RP-DAD-HPLC method.[Pubmed: 22545396]|
|Incensole and Incensole acetate, found in incense, are encouraging potent bioactive diterpenic cembrenoids, inhibiting Nuclear Factor-kappaB activation. Furthermore, Incensole acetate elicits psycho-activity in mice by activating the TRPV3 channels in the brain. Starting from crude extracts of the incense species Boswellia papyrifera Hochst., a convenient procedure for the efficient large-scale synthesis of incensole and its acetate is presented. Additionally, a reversed-phase, diode-array-detection, high-performance liquid chromatography (RP-DAD-HPLC) method for the quantification of incensole and Incensole acetate is reported, indicating that these two compounds are typical biomarkers for B. papyrifera.|
Brain Res. 2012 Mar 14;1443:89-97. doi: 10.1016/j.brainres.2012.01.001. Epub 2012 Jan 9.
|Protective effects of incensole acetate on cerebral ischemic injury.[Pubmed: 22284622]|
|Here, we show that Incensole acetate protects against ischemic neuronal damage and reperfusion injury in mice, attenuating the inflammatory nature of ischemic damage. Incensole acetate given post-ischemia, reduced infarct volumes and improved neurological activities in the mouse model of ischemic injury in a dose dependent fashion. The protection from damage was accompanied by inhibition of TNF-α, IL-1β and TGF-β expression, as well as NF-κB activation following injury. In addition, Incensole acetate is shown to have a therapeutic window of treatment up to 6h after ischemic injury. Finally, the protective effects of Incensole acetate were partially mediated by TRPV3 channels as determined by the TRPV3 deficient mice and channel blocker studies. This study suggests that the anti-inflammatory and neuroprotective activities of Incensole acetate may serve as a novel therapeutic treatment for ischemic and reperfusion injury, and as a tool in the ongoing research of mechanisms for neurological damage.|
J Psychopharmacol. 2012 Dec;26(12):1584-93. doi: 10.1177/0269881112458729. Epub 2012 Sep 26.
|Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals.[Pubmed: 23015543]|
|These data suggest that Incensole acetate modulates the hypothalamic-pituitary-adrenal (HPA) axis and influences hippocampal gene expression, leading to beneficial behavioral effects supporting its potential as a novel treatment of depressive-like disorders.|